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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Reversal of Lead-Induced Toxicity Due to the Effect of Antioxidants

Volume 32, Issue 2, 2013, pp. 177-187
DOI: 10.1615/JEnvironPatholToxicolOncol.2013006923
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ABSTRACT

This study was designated to evaluate the protective effect of glutathione (GSH) and N-acetyl cysteine (NAC) in reducing the concentration of lead acetate in blood and soft tissues (liver, kidney, and brain) and their ability to restore altered hematopoietic, hepatic, renal, and other biochemical variables that are indicative of tissue oxidative stress in male rats.
Male Wistar rats (150 ± 10 g) were randomly divided into 6 groups. Group 1 served as control. Group 2 served as experimental control was administered lead acetate (50 mg/kg intraperitoneally) for 3 days. Group 3 and 4 served as therapeutic controls. Animals in groups 5 and 6 received reduced GSH (1mg/kg intraperitoneally) and NAC (50 mg/kg orally) for 3 days after the administration of lead acetate, as in group 2.
The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, triglycerides, cholesterol, urea, and uric acid were significantly increased (P ≤ 0.05) following administration of lead acetate. Administration of GSH and NAC provided significant protection to thiobarbituric acid reactive substances levels and reduced GSH content in tissues. On the other hand, significant recovery in lead-sensitive biochemical indices, like δ-aminolevulinic acid dehydratase, δ-aminolevulinic acid, and lead concentration in blood and soft tissues also were observed. It was concluded that NAC provided maximum protection compared with reduced GSH.

CITED BY
  1. Omobowale Temidayo O., Oyagbemi Ademola A., Akinrinde Akinleye S., Saba Adebowale B., Daramola Oluwabusola T., Ogunpolu Blessing S., Olopade James O., Failure of recovery from lead induced hepatoxicity and disruption of erythrocyte antioxidant defence system in Wistar rats, Environmental Toxicology and Pharmacology, 37, 3, 2014. Crossref

  2. Karimfar Mohammad Hassan, Bargahi Afshar, Moshtaghi Darab, Farzadinia Parviz, Long-Term Exposure of Lead Acetate on Rabbit Renal Tissue, Iranian Red Crescent Medical Journal, 18, 2, 2016. Crossref

  3. Dai Haijiang, Huang Zhijun, Deng Qihong, Li Ying, Xiao Ting, Ning Xingping, Lu Yao, Yuan Hong, The Effects of Lead Exposure on Serum Uric Acid and Hyperuricemia in Chinese Adults: A Cross-Sectional Study, International Journal of Environmental Research and Public Health, 12, 8, 2015. Crossref

  4. Alcaraz-Contreras Y, Mendoza-Lozano RP, Martínez-Alcaraz ER, Martínez-Alfaro M, Gallegos-Corona MA, Ramírez-Morales MA, Vázquez-Guevara MA, Silymarin and dimercaptosuccinic acid ameliorate lead-induced nephrotoxicity and genotoxicity in rats, Human & Experimental Toxicology, 35, 4, 2016. Crossref

  5. Rossignol Daniel A., The Use of N-Acetylcysteine as a Chelator for Metal Toxicity, in The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine, 2019. Crossref

  6. Arrebola Juan Pedro, Ramos Juan José, Bartolomé Mónica, Esteban Marta, Huetos Olga, Cañas Ana I., López-Herranz Ana, Calvo Eva, Pérez-Gómez Beatriz, Castaño Argelia, Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study, Environment International, 123, 2019. Crossref

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