Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Role of Anti-MHC Class I Antibody in Facilitating Transplant Accommodation
ABSTRACT
The ligation of MHC class I molecules by class I antibodies on endothelial cells leads to both proliferation and survival signal transduction. This signaling pathway has been implicated in the development of acute and chronic antibody-mediated rejection. The ability of a graft to acquire resistance to immune-mediated graft injury is the basis of accommodation. The mechanisms of MHC class I-induced accommodation are unknown, but under certain circumstances following the ligation of MHC class I molecules by antibodies, the survival pathway is activated. This review explores what is currently known about accommodation and how MHC class I signaling may play a role in the process of enhancing graft survival.
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Mannam Venkat K.R., Lewis Robert E., Cruse Julius M., The fate of renal allografts hinges on responses of the microvascular endothelium, Experimental and Molecular Pathology, 94, 2, 2013. Crossref
-
Sarma Nayan J., Tiriveedhi Venkataswarup, Angaswamy Nataraju, Mohanakumar T., Role of antibodies to self-antigens in chronic allograft rejection: Potential mechanism and therapeutic implications, Human Immunology, 73, 12, 2012. Crossref
-
Iwasaki Kenta, Miwa Yuko, Haneda Masataka, Kuzuya Takafumi, Ogawa Haruko, Onishi Akira, Kobayashi Takaaki, AMP-activated protein kinase as a promoting factor, but complement and thrombin as limiting factors for acquisition of cytoprotection: implications for induction of accommodation, Transplant International, 26, 11, 2013. Crossref
-
Angaswamy Nataraju, Tiriveedhi Venkataswarup, Sarma Nayan J., Subramanian Vijay, Klein Christina, Wellen Jason, Shenoy Surendra, Chapman William C., Mohanakumar T., Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection, Human Immunology, 74, 11, 2013. Crossref
-
Gloor James, Stegall Mark D., Sensitized renal transplant recipients: current protocols and future directions, Nature Reviews Nephrology, 6, 5, 2010. Crossref
-
Rajalingam Raja, Zhang Qiuheng, Cecka J. Michael, Reed Elaine F., Transplant Antigen Biology, in Textbook of Organ Transplantation, 2014. Crossref
-
Nath Dilip S, Basha Haseeb Illias, Mohanakumar Thalachallour, Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection, Current Opinion in Organ Transplantation, 15, 1, 2010. Crossref
-
Seetharam Anil, Tiriveedhi Venkataswarup, Mohanakumar T, Alloimmunity and autoimmunity in chronic rejection, Current Opinion in Organ Transplantation, 15, 4, 2010. Crossref
-
Tait B. D., Hudson F., Brewin G., Cantwell L., Holdsworth R., Solid phase HLA antibody detection technology - challenges in interpretation, Tissue Antigens, 2010. Crossref
-
Dean P. G., Park W. D., Cornell L. D., Gloor J. M., Stegall M. D., Intragraft Gene Expression in Positive Crossmatch Kidney Allografts: Ongoing Inflammation Mediates Chronic Antibody-Mediated Injury, American Journal of Transplantation, 12, 6, 2012. Crossref
-
Naemi Fatmah M.A., Ali Simi, Kirby John A., Antibody-mediated allograft rejection: The emerging role of endothelial cell signalling and transcription factors, Transplant Immunology, 25, 2-3, 2011. Crossref
-
Nath Dilip S., Angaswamy Nataraju, Basha Haseeb Ilias, Phelan Donna, Moazami Nader, Ewald Gregory A., Mohanakumar T., Donor-specific antibodies to human leukocyte antigens are associated with and precede antibodies to major histocompatibility complex class I–related chain A in antibody-mediated rejection and cardiac allograft vasculopathy after human cardiac transplantation, Human Immunology, 71, 12, 2010. Crossref
-
Tiriveedhi V., Sarma N., Mohanakumar T., An important role for autoimmunity in the immunopathogenesis of chronic allograft rejection, International Journal of Immunogenetics, 39, 5, 2012. Crossref
-
Valenzuela Nicole M., Reed Elaine F., The link between major histocompatibility complex antibodies and cell proliferation, Transplantation Reviews, 25, 4, 2011. Crossref
-
Iwasaki Kenta, Miwa Yuko, Uchida Kazuharu, Kodera Yasuhiro, Kobayashi Takaaki, Negative regulation of HLA-DR expression on endothelial cells by anti-blood group A/B antibody ligation and mTOR inhibition, Transplant Immunology, 40, 2017. Crossref
-
Bharat Ankit, Mohanakumar T., Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection, Journal of Immunology Research, 2017, 2017. Crossref
-
Okada Manabu, Watarai Yoshihiko, Iwasaki Kenta, Futamura Kenta, Yamamoto Takayuki, Hiramitsu Takahisa, Tsujita Makoto, Goto Norihiko, Narumi Shunji, Takeda Asami, Kobayashi Takaaki, Lower incidence of de novo donor-specific antibodies against HLA-DR in ABO-incompatible renal transplantation, Human Immunology, 80, 3, 2019. Crossref