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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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RUNX3-Mediated Immune Cell Development and Maturation

Volume 38, Issue 1, 2018, pp. 63-78
DOI: 10.1615/CritRevImmunol.2018025488
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ABSTRACT

The transcription factor RUNX3 is a prominent regulator of multiple hematopoietic cell lineages. Gene loss of function studies demonstrated the unique and essential roles of this master regulator in differentiated lymphoid and myeloid cells. As a complementary approach, RUNX3 was upregulated in various leukocyte subsets to probe the instructive role of this 'multilineage'-specific transcription factor. In this report, we overview the immunomodulatory functions of RUNX3 within the hematopoietic compartment to gain insight into the consequences of Runx3 deletion or overexpression in committed immune cells. Genetic studies revealed the essential role of RUNX3 in Langerhans cell development. Moreover, this transcription factor is necessary for the differentiation and maintenance of the cytotoxic CD8+ T cells. In addition, T helper, natural killer, and B cells are also influenced by RUNX3. Importantly, the ectopic expression of Runx3 enhances the immunogenicity of cytotoxic T cells and pluripotent stem-cell-derived dendritic cells, suggesting that this protein can be applied in cell-based immunotherapies.

CITED BY
  1. Jawed Rohil, Zhang Mingming, Wang Chan, Yang Shu-Han, Jiang Peng, Wu Qiuyuan, Li Li, Chen Weichang, Gershwin M. Eric, Tian Ye, Seldin Michael F., Ma Xiong, Liu Xiangdong, Lian Zhe-Xiong, Shi Xingjuan, Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis, Immunogenetics, 72, 9-10, 2020. Crossref

  2. Aminu Abimbola J., Petkova Maria, Atkinson Andrew J., Yanni Joseph, Morris Alex D., Simms Robert T., Chen Weixuan, Yin Zeyuan, Kuniewicz Marcin, Holda Mateusz K., Kuzmin Vladislav S., Perde Filip, Molenaar Peter, Dobrzynski Halina, Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs, Progress in Biophysics and Molecular Biology, 166, 2021. Crossref

  3. Yin Honghao, Guo Rui, Zhang Huanyu, Liu Songyi, Gong Yuehua, Yuan Yuan, A Dynamic Transcriptome Map of Different Tissue Microenvironment Cells Identified During Gastric Cancer Development Using Single-Cell RNA Sequencing, Frontiers in Immunology, 12, 2021. Crossref

  4. Wu Yating, Zhu Jianbo, Liu Haifeng, Liu Hailiang, Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation, Aging, 13, 6, 2021. Crossref

  5. Wang Jun, Liu Cong, Chen Yue, Wang Wei, Taiji-reprogram: a framework to uncover cell-type specific regulators and predict cellular reprogramming cocktails, NAR Genomics and Bioinformatics, 3, 4, 2021. Crossref

  6. Wang Faming, Cui Dongya, Zhang Qingyun, Shao Yingying, Zheng Baijiao, Chen Liling, Luo Yao, Yuan Liudi, Wang Demin, LncRNA00492 is required for marginal zone B‐cell development, Immunology, 165, 1, 2022. Crossref

  7. Andrews Jared M., Pyfrom Sarah C., Schmidt Jennifer A., Koues Olivia I., Kowalewski Rodney A., Grams Nicholas R., Sun Jessica J., Berman Leigh R., Duncavage Eric J., Lee Yi-Shan, Cashen Amanda F., Oltz Eugene M., Payton Jacqueline E., Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers, EBioMedicine, 71, 2021. Crossref

  8. Li Zhenhua, Yang Quanli, Tang Xin, Chen Yiming, Wang Shanshan, Qi Xiaojie, Zhang Yawen, Liu Zonghua, Luo Jing, Liu Hui, Ba Yongbing, Guo Lianxia, Wu Baojian, Huang Fang, Cao Guangchao, Yin Zhinan, Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells, Science Bulletin, 67, 4, 2022. Crossref

  9. Tibbs Ellis, Cao Xuefang, Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease, Cancers, 14, 6, 2022. Crossref

  10. Feng Zhang, Liu Yanxin, Chen Huaxia, Integrated Analysis of the Expression, Involved Functions, and Regulatory Network of RUNX3 in Melanoma, Combinatorial Chemistry & High Throughput Screening, 25, 9, 2022. Crossref

  11. Bao Chen-hui, Guo Lin, miR-27b-3p Inhibits Invasion, Migration and Epithelial-mesenchymal Transition in Gastric Cancer by Targeting RUNX1 and Activation of the Hippo Signaling Pathway, Anti-Cancer Agents in Medicinal Chemistry, 22, 5, 2022. Crossref

  12. Hu Kai, Liu Haibo, Lawson Nathan D., Zhu Lihua Julie, scATACpipe: A nextflow pipeline for comprehensive and reproducible analyses of single cell ATAC-seq data, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

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