Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Transcription Factors and Th17 Cell Development in Experimental Autoimmune Encephalomyelitis
ABSTRACT
Experimental autoimmune encephalomyelitis (EAE), a widely studied animal model of human central nervous system demyelinating diseases such as multiple sclerosis, is a T-cell-mediated autoimmune disease involving effector T helper (Th) subsets such as Th and Th7. Recently, Th7 cells have been shown to play a major role in many autoimmune and other inflammatory diseases. The development of Th subsets is controlled by a complex network of cytokines and signaling and transcription molecules that act to augment the development of one cell type while restricting the development of other lineages. Here, we review the transcription factors (TFs) that are required for Th17 cell development in EAE and classify them into three types: major or essential such as RORγt and STAT3, an array of helper factors that work in combination with or regulate the expression of the major factors, and regulatory TFs that attenuate the expression of Th17 genes. The plasticity of the Th17 cell lineage is also discussed in relation to the interaction of TFs that play a major role in the development of other Th or regulatory T cell (Treg) lineages such as T-bet and Foxp3 with the Th17 TFs.
-
Wheeler Jennifer L. H., Martin Kyle C., Resseguie Emily, Lawrence B. Paige, Differential Consequences of Two Distinct AhR Ligands on Innate and Adaptive Immune Responses to Influenza A Virus, Toxicological Sciences, 137, 2, 2014. Crossref
-
Kong Weimin, Li Hongbo, Tuma Ronald F., Ganea Doina, Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS, Cellular Immunology, 287, 1, 2014. Crossref
-
Zhang Lanfang, Guo Yixian, Xia Chang-Qing, Infusion of Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate-Conjugated MOG35–55-Coupled Spleen Cells Effectively Prevents and Reverses Experimental Autoimmune Encephalomyelitis in Mice, Journal of Immunology Research, 2015, 2015. Crossref
-
Sun Yanyong, Lehmbecker Annika, Kalkuhl Arno, Deschl Ulrich, Sun Wenhui, Rohn Karl, Tzvetanova Iva D., Nave Klaus-Armin, Baumgärtner Wolfgang, Ulrich Reiner, STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis, Neuropathology and Applied Neurobiology, 41, 3, 2015. Crossref
-
Kotkowska Agnieszka, Sewerynek Ewa, Domańska Daria, Pastuszak-Lewandoska Dorota, Brzeziańska Ewa, Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion, Cellular and Molecular Biology Letters, 20, 1, 2015. Crossref
-
Zhang Jiang, Li Zhenlong, Hu Xuefei, Su Qiong, He Cong, Liu Jing, Ren Hua, Qian Min, Liu Junling, Cui Shufang, Jiang Wenzheng, Knockout of P2Y 12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells, Brain, Behavior, and Immunity, 62, 2017. Crossref
-
Parastouei Karim, Mirshafiey Abbas, Eshraghian Mohammad Reza, Shiri-Shahsavar Mohammad Reza, Solaymani-Mohammadi Farid, Chahardoli Reza, Alvandi Ehsan, Saboor-Yaraghi Ali Akbar, The effect of 1, 25(OH)2 D3 (calcitriol) alone and in combination with all-trans retinoic acid on ROR-γt, IL-17, TGF-β, and FOXP3 gene expression in experimental autoimmune encephalomyelitis, Nutritional Neuroscience, 21, 3, 2018. Crossref
-
Fontes Lívia B.A., Dias Débora dos S., Aarestrup Beatriz J.V., Aarestrup Fernando M., Da Silva Filho Ademar A., Corrêa José Otávio do Amaral, β -Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis in C57BL/6 mice, Biomedicine & Pharmacotherapy, 91, 2017. Crossref
-
Speck Suzanne, Lim James, Shelake Sagar, Matka Marsel, Stoddard Jonathan, Farr Alexander, Kuchroo Vijay, Laouar Yasmina, Sutterwala Fayyaz S., TGF-β Signaling Initiated in Dendritic Cells Instructs Suppressive Effects on Th17 Differentiation at the Site of Neuroinflammation, PLoS ONE, 9, 7, 2014. Crossref
-
Ahn Meejung, Kim Jeongtae, Park Changnam, Cho Jinhee, Jee Youngheun, Jung Kyungsook, Moon Changjong, Shin Taekyun, Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment, Anatomy & Cell Biology, 50, 1, 2017. Crossref
-
Melnikov Mikhail, Rogovskii Vladimir, Boykо Alexey, Pashenkov Mikhail, Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions, Journal of Neuroimmune Pharmacology, 15, 1, 2020. Crossref
-
Zarobkiewicz Michał K., Kowalska Wioleta, Halczuk Paweł, Woś Justyna, Jodłowska-Jędrych Barbara, Rejdak Konrad, Roliński Jacek, Bojarska-Junak Agnieszka A., RORγT is overexpressed in iNKT and γδ T cells during relapse in relapsing-remitting multiple sclerosis, Journal of Neuroimmunology, 337, 2019. Crossref
-
Li Zhi-Hui, Wang Yi-Fei, He Dan-Dan, Zhang Xue-Mei, Zhou Ying-Lian, Yue Hui, Huang Shan, Fu Zheng, Zhang Ling-Yu, Mao Zhu-Qing, Li Shuang, Zhang Chen-Yu, Chen Xi, Fu Jin, Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis, Aging, 11, 13, 2019. Crossref
-
Ahn Meejung, Kim Jeongtae, Park Changnam, Jung Kyungsook, Moon Changjong, Shin Taekyun, Immunohistochemical study of Krüppel-like factor 4 in the spinal cords of rats with experimental autoimmune encephalomyelitis, Acta Histochemica, 117, 6, 2015. Crossref