Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
A Chimerism-Based Approach to Induce Tolerance in IgE-Mediated Allergy
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ABSTRACT
Immunoglobulin-E-mediated allergy (type I allergy) is a T-helper-2-mediated disease with increasing prevalence in industrialized countries. Immunotherapy is available as causative treatment, but an effective preventive strategy is still an unmet need. Molecular chimerism is an attractive experimental approach that induces tolerance through transplantation of autologous hematopoietic stem cells that are genetically modified to express the disease-causing antigen(s). Molecular chimerism leads to permanent and robust tolerance in experimental models of autoimmune diseases and organ transplantation. Recently, proof-of-principle studies demonstrated that a type I allergic immune response can be durably tolerized by transplantation of allergen-expressing syngeneic bone marrow. We review the concept of tolerance induction through chimerism and discuss the potential of this strategy in immunoglobulin-E-mediated allergy.
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Baranyi U., Pilat N., Gattringer M., Linhart B., Klaus C., Schwaiger E., Iacomini J., Valenta R., Wekerle T., Persistent molecular microchimerism induces long-term tolerance towards a clinically relevant respiratory allergen, Clinical & Experimental Allergy, 42, 8, 2012. Crossref
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Gattringer Martina, Baranyi Ulrike, Pilat Nina, Hock Karin, Klaus Christoph, Buchberger Elisabeth, Ramsey Haley, Iacomini John, Valenta Rudolf, Wekerle Thomas, Engraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance, Immunobiology, 218, 9, 2013. Crossref
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Baranyi Ulrike, Gattringer Martina, Farkas Andreas M., Hock Karin, Pilat Nina, Iacomini John, Valenta Rudolf, Wekerle Thomas, The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism, European Journal of Immunology, 43, 9, 2013. Crossref
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Baranyi Ulrike, Gattringer Martina, Valenta Rudolf, Wekerle Thomas, Cell-Based Therapy in Allergy, in Vaccines against Allergies, 352, 2011. Crossref
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Current World Literature, Current Opinion in Allergy & Clinical Immunology, 10, 6, 2010. Crossref