Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
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A Cell Death Pathway Induced by Antibody-Mediated Cross-Linking of CD45 on Lymphocytes
ABSTRACT
The protein tyrosine phosphatase CD45 is a highly expressed glycoprotein present on all nucleated cells of hematopoietic origin. To date, all the functions attributed to CD45 are inherently coupled to its phosphatase activity. For instance, the regulation of lymphocyte antigen receptor signaling is mediated through the dephosphorylation, and hence activation, of Src-family kinases by CD45. Moreover, signaling via cytokine receptors is negatively modulated by CD45 by dephosphorylation of Janus kinase family members. Recently, another function for CD45, unrelated to regulation of surface receptor signaling, has been unraveled. Specific engagement of CD45 by monoclonal antibodies at the surface of lymphocytes induced their death, through an alternative caspase-independent pathway. In striking contrast to all other previously reported functions for CD45, its phosphatase activity is completely dispensable for the induction of cell death. This article reviews the current knowledge on the death pathway triggered by CD45 ligation on lymphocytes. In an attempt to better elucidate the mechanism of cell death induction through CD45, we also provide original data regarding the susceptibility of various subsets of immature and mature T and B cells to death induced by CD45 engagement. The physiological significance and therapeutic potential of CD45-induced death are also discussed.
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Walter Roland B., Boyle Kelli M., Appelbaum Frederick R., Bernstein Irwin D., Pagel John M., Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells and improves survival of mice bearing human AML xenografts, Blood, 111, 9, 2008. Crossref
-
Fong Chui Yee, Peh Gary S. L., Gauthaman Kalamegam, Bongso Ariff, Separation of SSEA-4 and TRA-1–60 Labelled Undifferentiated Human Embryonic Stem Cells from A Heterogeneous Cell Population Using Magnetic-Activated Cell Sorting (MACS) and Fluorescence-Activated Cell Sorting (FACS), Stem Cell Reviews and Reports, 5, 1, 2009. Crossref
-
Tchilian Elma Z., Beverley Peter C.L., Altered CD45 expression and disease, Trends in Immunology, 27, 3, 2006. Crossref
-
Guendel Irene, Iordanskiy Sergey, Sampey Gavin C., Van Duyne Rachel, Calvert Valerie, Petricoin Emanuel, Saifuddin Mohammed, Kehn-Hall Kylene, Kashanchi Fatah, Role of Bruton’s tyrosine kinase inhibitors in HIV-1-infected cells, Journal of NeuroVirology, 21, 3, 2015. Crossref
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Antoine-Moussiaux Nicolas, Cornet Anne, Cornet François, Glineur Stéphanie, Dermine Martin, Desmecht Daniel, Rénia Laurent, A Non-Cytosolic Protein of Trypanosoma evansi Induces CD45-Dependent Lymphocyte Death, PLoS ONE, 4, 5, 2009. Crossref
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Pericolini Eva, Gabrielli Elena, Bistoni Giovanni, Cenci Elio, Perito Stefano, Chow Siu-Kei, Riuzzi Francesca, Donato Rosario, Casadevall Arturo, Vecchiarelli Anna, Fritz Jörg Hermann, Role of CD45 Signaling Pathway in Galactoxylomannan-Induced T Cell Damage, PLoS ONE, 5, 9, 2010. Crossref
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Liu Zhe, Dawes Ritu, Petrova Svetla, Beverley Peter CL, Tchilian Elma Z, CD45 regulates apoptosis in peripheral T lymphocytes, International Immunology, 18, 6, 2006. Crossref
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Gilner Jennifer B., Walton William G., Gush Kimberly, Kirby Suzanne L., Antibodies to Stem Cell Marker Antigens Reduce Engraftment of Hematopoietic Stem Cells, Stem Cells, 25, 2, 2007. Crossref