Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
IL-7 and Its Beneficial Role in Sepsis-Induced T Lymphocyte Dysfunction
ABSTRACT
Sepsis, defined as life-threatening organ dysfunction caused by dysregulated host response to infection, has recently been acknowledged as a worldwide health priority. Sepsis remains the leading cause of mortality in intensive care units and accounts for 6 million deaths every year. Few therapeutic options targeting host immune response in sepsis have demonstrated their efficacy so far. Increasing evidence suggests that a profound immune suppression develops following sepsis, affecting innate and adaptive immune response, of which intensity and duration is associated with increased risk of death and nosocomial infection. Immunostimulant treatments are thus now evaluated in sepsis, and recombinant human IL-7 (rhIL-7) represents a promising candidate. rhIL-7 has been evaluated in several clinical trials in patients with altered lymphocytic responses (HIV infection, hematopoietic stem cell transplantation, and cancer). Recent studies in animal models and in patients' samples ex vivo demonstrated its efficacy in improving sepsis-induced T cell alterations. Finally, the first clinical trial evaluating rhIL-7 in septic shock patients has just been published. This review will discuss the use of rhIL-7 to treat sepsis-induced T cell dysfunction by introducing the pathophysiology of sepsis and sepsis-related lymphocyte alterations before focusing on rhIL-7 and its potential use of as a therapeutic intervention in patients.
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Bidar Frank, Hamada Sarah, Gossez Morgane, Coudereau Remy, Lopez Jonathan, Cazalis Marie-Angelique, Tardiveau Claire, Brengel-Pesce Karen, Mommert Marine, Buisson Marielle, Conti Filippo, Rimmelé Thomas, Lukaszewicz Anne-Claire, Argaud Laurent, Cour Martin, Monneret Guillaume, Venet Fabienne, Pescarmona Remi, Garnier Lorna, Lombard Christine, Perret Magali, Villard Marine, Viel Sébastien, Cheynet Valérie, Cerrato Elisabeth, Peronnet Estelle, Llitjos Jean-François, Itah Laetitia, Boussaha Inesse, Poitevin-Later Françoise, Malcus Christophe, Godignon Marine, Wallet Florent, Delignette Marie-Charlotte, Dailler Frederic, Simon Marie, Dargent Auguste, Bertrand Pierre-Jean, Stevic Neven, Provent Marion, Bignet Laurie, Cerro Valérie, Richard Jean-Christophe, Bitker Laurent, Mezidi Mehdi, Baboi Loredana, Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients, Annals of Intensive Care, 12, 1, 2022. Crossref
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Chen Hongyan, Zhang Xiaoting, Su Hao, Zeng Judeng, Chan Hung, Li Qing, Liu Xiaodong, Zhang Lin, Wu William Ka Kei, Chan Matthew Tak Vai, Chen Huarong, Immune dysregulation and RNA N6 ‐methyladenosine modification in sepsis , WIREs RNA, 2022. Crossref