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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

IL-7 and Its Beneficial Role in Sepsis-Induced T Lymphocyte Dysfunction

Volume 38, Issue 6, 2018, pp. 433-451
DOI: 10.1615/CritRevImmunol.2018027460
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ABSTRACT

Sepsis, defined as life-threatening organ dysfunction caused by dysregulated host response to infection, has recently been acknowledged as a worldwide health priority. Sepsis remains the leading cause of mortality in intensive care units and accounts for 6 million deaths every year. Few therapeutic options targeting host immune response in sepsis have demonstrated their efficacy so far. Increasing evidence suggests that a profound immune suppression develops following sepsis, affecting innate and adaptive immune response, of which intensity and duration is associated with increased risk of death and nosocomial infection. Immunostimulant treatments are thus now evaluated in sepsis, and recombinant human IL-7 (rhIL-7) represents a promising candidate. rhIL-7 has been evaluated in several clinical trials in patients with altered lymphocytic responses (HIV infection, hematopoietic stem cell transplantation, and cancer). Recent studies in animal models and in patients' samples ex vivo demonstrated its efficacy in improving sepsis-induced T cell alterations. Finally, the first clinical trial evaluating rhIL-7 in septic shock patients has just been published. This review will discuss the use of rhIL-7 to treat sepsis-induced T cell dysfunction by introducing the pathophysiology of sepsis and sepsis-related lymphocyte alterations before focusing on rhIL-7 and its potential use of as a therapeutic intervention in patients.

CITED BY
  1. Nowill Alexandre E., de Campos-Lima Pedro O., Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2–Induced Cytokine Storm, The Journal of Immunology, 205, 10, 2020. Crossref

  2. Ducloux Didier, Legendre Mathieu, Bamoulid Jamal, Saas Philippe, Courivaud Cécile, Crepin Thomas, End-Stage Renal Disease-Related Accelerated Immune Senescence: Is Rejuvenation of the Immune System a Therapeutic Goal?, Frontiers in Medicine, 8, 2021. Crossref

  3. Bidar Frank, Hamada Sarah, Gossez Morgane, Coudereau Remy, Lopez Jonathan, Cazalis Marie-Angelique, Tardiveau Claire, Brengel-Pesce Karen, Mommert Marine, Buisson Marielle, Conti Filippo, Rimmelé Thomas, Lukaszewicz Anne-Claire, Argaud Laurent, Cour Martin, Monneret Guillaume, Venet Fabienne, Pescarmona Remi, Garnier Lorna, Lombard Christine, Perret Magali, Villard Marine, Viel Sébastien, Cheynet Valérie, Cerrato Elisabeth, Peronnet Estelle, Llitjos Jean-François, Itah Laetitia, Boussaha Inesse, Poitevin-Later Françoise, Malcus Christophe, Godignon Marine, Wallet Florent, Delignette Marie-Charlotte, Dailler Frederic, Simon Marie, Dargent Auguste, Bertrand Pierre-Jean, Stevic Neven, Provent Marion, Bignet Laurie, Cerro Valérie, Richard Jean-Christophe, Bitker Laurent, Mezidi Mehdi, Baboi Loredana, Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients, Annals of Intensive Care, 12, 1, 2022. Crossref

  4. Torres Lisa K., Pickkers Peter, van der Poll Tom, Sepsis-Induced Immunosuppression, Annual Review of Physiology, 84, 1, 2022. Crossref

  5. Chen Hongyan, Zhang Xiaoting, Su Hao, Zeng Judeng, Chan Hung, Li Qing, Liu Xiaodong, Zhang Lin, Wu William Ka Kei, Chan Matthew Tak Vai, Chen Huarong, Immune dysregulation and RNA N6 ‐methyladenosine modification in sepsis , WIREs RNA, 2022. Crossref

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