Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Non-Major Histocompatibility Complex Rheumatoid Arthritis Susceptibility Genes

Volume 31, Issue 2, 2011, pp. 99-114
DOI: 10.1615/CritRevImmunol.v31.i2.20
Get accessGet access

ABSTRACT

Recent results from genetic and treatment studies have shed new light on chronic inflammatory and autoimmune diseases such as rheumatoid arthritis (RA). In particular, genome-wide association studies (GWAS) have provided supportive evidence that RA is a disease with a strong genetic background. Interestingly, a series of candidate genes have been identified outside of the classical major histocompatibility (MHC) locus, which had long been regarded as the major contributor to the pathogenesis of this disease. Among these genes, PTPN22 plays an outstanding role. CD40, STAT4, PRM1, and TNFAIP3 also seem to be of relevance. Interestingly, there is a significant overlap between RA susceptibility genes and those of other autoimmune diseases such as systemic lupus erythematosus (SLE) and type 1 diabetes, which suggests common pathogenic mechanisms. Genetic analyses may not only provide new insights into the pathogenesis of RA, but may also open new avenues for therapeutic approaches, because overactive immune-signaling pathways might specifically be addressed by biologic therapies. However, the predictive value of many of the recent findings of large-scale genetic analyses in identifying new genetic polymorphisms remains low. We describe the current knowledge about the role of non-MHC genes in the pathogenesis of rheumatoid arthritis.

CITED BY
  1. Cutolo Maurizio, Nadler Steven G., Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis, Autoimmunity Reviews, 12, 7, 2013. Crossref

  2. Viatte Sebastien, Plant Darren, Raychaudhuri Soumya, Genetics and epigenetics of rheumatoid arthritis, Nature Reviews Rheumatology, 9, 3, 2013. Crossref

  3. Amur Shashi, Parekh Ameeta, Mummaneni Padmaja, Sex differences and genomics in autoimmune diseases, Journal of Autoimmunity, 38, 2-3, 2012. Crossref

  4. Chang Hui-Hsin, Liu Guang-Yaw, Dwivedi Nishant, Sun Bo, Okamoto Yuko, Kinslow Jennifer D., Deane Kevin D., Demoruelle M. Kristen, Norris Jill M., Thompson Paul R., Sparks Jeffrey A., Rao Deepak A., Karlson Elizabeth W., Hung Hui-Chih, Holers V. Michael, Ho I-Cheng, A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22, JCI Insight, 1, 17, 2016. Crossref

  5. Venkatesha SH, Dudics S, Weingartner E, So EC, Pedra JHF, Moudgil KD, Altered Th17/Treg balance and dysregulated IL-1β response influence susceptibility/resistance to experimental autoimmune arthritis, International Journal of Immunopathology and Pharmacology, 28, 3, 2015. Crossref

  6. Dwivedi Nishant, Chang Hui-Hsin, Ho I-Cheng, Citrullination and Neutrophil Extracellular Traps, in Protein Deimination in Human Health and Disease, 2017. Crossref

  7. Shi Lipu, Wei Yanlin, Xun Wen, Han Dan, Meta-Analysis of the Correlation Between PTPN22 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus, Asia Pacific Journal of Public Health, 25, 4_suppl, 2013. Crossref

  8. Chang Hui-Hsin, Tai Tzong-Shyuan, Lu Bing, Iannaccone Christine, Cernadas Manuela, Weinblatt Michael, Shadick Nancy, Miaw Shi-Chuen, Ho I-Cheng, Allen Rachel Louise, PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis, PLoS ONE, 7, 3, 2012. Crossref

  9. Dorak Mehmet Tevfik, Yazici Yusuf, Biomarkers, Genetic Association, and Genomic Studies, in Understanding Evidence-Based Rheumatology, 2014. Crossref

  10. Al Naqbi Halima, Mawart Aurélie, Alshamsi Jawaher, Al Safar Habiba, Tay Guan K., Major histocompatibility complex (MHC) associations with diseases in ethnic groups of the Arabian Peninsula, Immunogenetics, 73, 2, 2021. Crossref

  11. Ota Yuko, Kuwana Masataka, Updates on genetics in systemic sclerosis, Inflammation and Regeneration, 41, 1, 2021. Crossref

Forthcoming Articles

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain