Published 6 issues per year
ISSN Print: 0743-4863
ISSN Online: 2162-660X
Indexed in
Mucosal Drug Delivery: Membranes, Methodologies, and Applications
ABSTRACT
In recent years, extensive research into novel forms of drug delivery has suggested that mucosal approaches offer a promising therapeutic alternative, especially for systemically acting drugs. Transmucosal drug delivery offers many benefits, including noninvasive administration, convenience, rapid onset, as well as elimination of hepatic first-pass metabolism. The investigated absorptive surfaces consist of the nasal, buccal, ocular, vaginal, and rectal mucosae. Among these, the nasal and buccal routes have proved the most promising to date. The bioavailability achieved mainly depends upon the pathophysiological state of the mucosa and the properties of both the drug and delivery systems. Various agents can increase the efficacy of transmucosal drug delivery. These include cyclodextrins, bile salts, surfactants, fusidic acid derivatives, microspheres, liposomes, and bioadhesive agents.The mechanisms of action, effectiveness, and toxicity profiles of these enhancers have been investigated extensively in both animal and human models.
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Turunen Elina, Mannila Janne, Laitinen Riikka, Riikonen Joakim, Lehto Vesa-Pekka, Järvinen Tomi, Ketolainen Jarkko, Järvinen Kristiina, Jarho Pekka, Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits, Journal of Pharmacy and Pharmacology, 63, 1, 2010. Crossref
-
Vauthier Christine, Bertholon Isabelle, Labarre Denis, Integrated Development of Glycobiologics: from Discovery to Applications in the Design of Nanoparticular Drug Delivery Systems, in Pharmaceutical Sciences Encyclopedia, 2010. Crossref
-
BONHAGE M. R., CHILCOAT C. D., LI Q., MELENDEZ V., FLOURNOY W. S., Evaluation of two scopolamine and physostigmine pretreatment regimens against nerve agent poisoning in the dog, Journal of Veterinary Pharmacology and Therapeutics, 32, 2, 2009. Crossref
-
Sandri Giuseppina, Bonferoni Maria Cristina, Ferrari Franca, Rossi Silvia, Caramella Carla, Differentiating Factors between Oral Fast-Dissolving Technologies, American Journal of Drug Delivery, 4, 4, 2006. Crossref
-
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-
Luna E., Postol E., Caldas C., Benvenuti L. A., Rodrigues J. M., Lima K., Kalil J., Coelho V., Treatment with Encapsulated Hsp60 Peptide (p277) Prolongs Skin Graft Survival in a Murine Model of Minor Antigen Disparity, Scandinavian Journal of Immunology, 66, 1, 2007. Crossref
-
Smart John D, Buccal drug delivery, Expert Opinion on Drug Delivery, 2, 3, 2005. Crossref
-
Furubayashi Tomoyuki, Inoue Daisuke, Kamaguchi Akiko, Higashi Yutaka, Sakane Toshiyasu, Influence of Formulation Viscosity on Drug Absorption Following Nasal Application in Rats, Drug Metabolism and Pharmacokinetics, 22, 3, 2007. Crossref
-
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-
Hu Longsheng, Damaj Bassam B., Martin Richard, Michniak-Kohn Bozena B., Enhanced in vitro transbuccal drug delivery of ondansetron HCl, International Journal of Pharmaceutics, 404, 1-2, 2011. Crossref
-
Aşıkoğlu Makbule, Özgüney Işık, Özcan İpek, Örümlü Oya, Güneri Tamer, Köseoğlu Kamil, Özkılıç Hayal, The Absorption of99mTc-alendronate Given by Rectal Route in Rabbits, Pharmaceutical Development and Technology, 13, 3, 2008. Crossref
-
Losso Jack, Development and Delivery of Anti-Angiogenic Functional Food Products, in Anti-Angiogenic Functional and Medicinal Foods, 20072347, 2007. Crossref
-
Leonard Alexis Kays, Sileno Anthony P., Brandt Gordon C., Foerder Charles A., Quay Steven C., Costantino Henry R., In vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo, International Journal of Pharmaceutics, 335, 1-2, 2007. Crossref
-
Costantino Henry R., Illum Lisbeth, Brandt Gordon, Johnson Paul H., Quay Steven C., Intranasal delivery: Physicochemical and therapeutic aspects, International Journal of Pharmaceutics, 337, 1-2, 2007. Crossref
-
Smart John D., Keegan Gemma, Buccal Drug Delivery Systems, in Oral Controlled Release Formulation Design and Drug Delivery, 2010. Crossref
-
das Neves J., Bahia M.F., Gels as vaginal drug delivery systems, International Journal of Pharmaceutics, 318, 1-2, 2006. Crossref
-
Peppas Nicholas A., Carr Daniel A., Impact of absorption and transport on intelligent therapeutics and nanoscale delivery of protein therapeutic agents, Chemical Engineering Science, 64, 22, 2009. Crossref
-
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-
Kong Bin, Sun Yong, Li Yongjian, Hu Dejian, Preparation and the Influencing Factors of Timozolomide Liposomes, Artificial Cells, Blood Substitutes, and Biotechnology, 37, 6, 2009. Crossref
-
Maggio Edward T., Pillion Dennis J., High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers, Drug Delivery and Translational Research, 3, 1, 2013. Crossref
-
Colombo P., Cagnani S., Buttini F., Santi P., Sonvico F., Russo P., Colombo G., Biological In Vitro Models for Absorption by Non-Oral Routes, in Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2013. Crossref
-
Kumar Krishan, Dhawan Neha, Sharma Harshita, Vaidya Shubha, Vaidya Bhuvaneshwar, Bioadhesive polymers: Novel tool for drug delivery, Artificial Cells, Nanomedicine, and Biotechnology, 42, 4, 2014. Crossref
-
He Biao, Zheng Bo-jian, Wang Qian, Du Lanying, Jiang Shibo, Lu Lu, Adenovirus-based vaccines against avian-origin H5N1 influenza viruses, Microbes and Infection, 17, 2, 2015. Crossref
-
Poet Torka S., Timchalk Charles, Hotchkiss Jon A., Bartels Michael J., Chlorpyrifos PBPK/PD model for multiple routes of exposure, Xenobiotica, 44, 10, 2014. Crossref
-
Ruggeri Matteo, Turriziani Adriana, Oradei Marco, Cost-effectiveness analysis of transnasal fentanyl citrate for the treatment of breakthrough cancer pain, Expert Review of Pharmacoeconomics & Outcomes Research, 14, 3, 2014. Crossref
-
Johal Himmat Singh, Garg Tarun, Rath Goutam, Goyal Amit Kumar, Advanced topical drug delivery system for the management of vaginal candidiasis, Drug Delivery, 23, 2, 2016. Crossref
-
Bouchal F., Skiba M., Chaffai N., Hallouard F., Fatmi S., Lahiani-Skiba M., Fast dissolving cyclodextrin complex of piroxicam in solid dispersion Part I: Influence of β-CD and HPβ-CD on the dissolution rate of piroxicam, International Journal of Pharmaceutics, 478, 2, 2015. Crossref
-
Buccal Route and Ingestion, in Nanomedicines and Nanoproducts, 2015. Crossref
-
Colombo P., Cagnani S., Sonvico F., Santi P., Russo P., Colombo G., Biological In Vitro Models for Absorption by Nonoral Routes, in Comprehensive Medicinal Chemistry II, 2007. Crossref
-
Laffleur Flavia, Mucoadhesive therapeutic compositions: a patent review (2011-2014), Expert Opinion on Therapeutic Patents, 26, 3, 2016. Crossref
-
Bonferoni Maria Cristina, Sandri Giuseppina, Rossi Silvia, Ferrari Franca, Caramella Carla, Chitosan and its salts for mucosal and transmucosal delivery, Expert Opinion on Drug Delivery, 6, 9, 2009. Crossref
-
Yu Tao, Chisholm Jane, Choi Woo Jin, Anonuevo Abraham, Pulicare Sarah, Zhong Weixi, Chen Minmin, Fridley Colleen, Lai Samuel K., Ensign Laura M., Suk Jung Soo, Hanes Justin, Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces, Advanced Healthcare Materials, 5, 21, 2016. Crossref
-
Mirza Mohd. Aamir, Panda Amulya K., Asif S., Verma Devina, Talegaonkar Sushama, Manzoor Nikhat, Khan Amber, Ahmed Farhan Jalees, Dudeja Mridu, Iqbal Zeenat, A vaginal drug delivery model, Drug Delivery, 23, 8, 2016. Crossref
-
Battu Sunil Kumar, Repka Michael A., Majumdar Soumyajit, Rao Y Madhusudan, Formulation and Evaluation of Rapidly Disintegrating Fenoverine Tablets: Effect of Superdisintegrants, Drug Development and Industrial Pharmacy, 33, 11, 2007. Crossref
-
Rohan L. C., Devlin B., Yang H., Microbicide Dosage Forms, in Microbicides for Prevention of HIV Infection, 383, 2013. Crossref
-
Inoue Daisuke, Tanaka Akiko, Kimura Shunsuke, Kiriyama Akiko, Katsumi Hidemasa, Yamamoto Akira, Ogawara Ken-ichi, Kimura Toshikiro, Higaki Kazutaka, Yutani Reiko, Sakane Toshiyasu, Furubayashi Tomoyuki, The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption, European Journal of Pharmaceutical Sciences, 117, 2018. Crossref
-
Kaufman Paul L., Gabelt B’Ann True, Future of IOP-Lowering Medication for Glaucoma Therapy, in Glaucoma, 2006. Crossref
-
Barbour Nancy P., Lipper Robert A., Introduction to Biopharmaceutics and its Role in Drug Development, in Biopharmaceutics Applications in Drug Development, 2008. Crossref
-
Li Bi Lian, Yuen Vivian Man-ying, Zhang Na, Zhang Huan Huan, Huang Jun Xiang, Yang Si Yuan, Miller Jeffery W., Song Xing Rong, A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism, Journal of Autism and Developmental Disorders, 49, 9, 2019. Crossref
-
Bykova A. F., Ivanov I. M., Grebenyuk A. N., PROBLEMS AND PROSPECTS OF INHALATION APPLICATION OF PEPTIDE AND PROTEIN COMPOUNDS AS POTENTIAL MEDICAL RADIATION PROTECTIVE AGENTS, Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations, 2, 2018. Crossref
-
Lalan Manisha S., Patel Vivek N., Misra Ambikanandan, Polymers in Vaginal Drug Delivery: Recent Advancements, in Applications of Polymers in Drug Delivery, 2021. Crossref
-
Riaz Amina, Hendricks Sarah, Elbrink Kimberley, Guy Caljon, Maes Louis, Ahmed Naveed, Kiekens Filip, Khan Gul Majid, Preparation and Characterization of Nanostructured Lipid Carriers for Improved Topical Drug Delivery: Evaluation in Cutaneous Leishmaniasis and Vaginal Candidiasis Animal Models, AAPS PharmSciTech, 21, 5, 2020. Crossref
-
Inoue Daisuke, Kimura Shunsuke, Kiriyama Akiko, Katsumi Hidemasa, Yamamoto Akira, Ogawara Ken-ichi, Higaki Kazutaka, Tanaka Akiko, Yutani Reiko, Sakane Toshiyasu, Furubayashi Tomoyuki, Quantitative Estimation of the Effect of Nasal Mucociliary Function on in Vivo Absorption of Norfloxacin after Intranasal Administration to Rats, Molecular Pharmaceutics, 15, 10, 2018. Crossref
-
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-
Uchida Hiroshi, Kondoh Masuo, Hanada Takeshi, Takahashi Azusa, Hamakubo Takao, Yagi Kiyohito, A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide, Biochemical Pharmacology, 79, 10, 2010. Crossref
-
Mura Paola, Maestrelli Francesca, Cirri Marzia, Mennini Natascia, Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review, Marine Drugs, 20, 5, 2022. Crossref
-
Schmitt Laurenz, Marquardt Yvonne, Heise Ruth, von Felbert Verena, Amann Philipp M., Huth Laura, Steiner Timm, Hölzle Frank, Huth Sebastian, Baron Jens Malte, Novel Human Full-Thickness Three-Dimensional Nonkeratinized Mucous Membrane Model for Pharmacological Studies in Wound Healing, Skin Pharmacology and Physiology, 32, 5, 2019. Crossref
-
Ammar H. O., Haider M., Ibrahim M., El Hoffy N. M., In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration, Drug Delivery, 24, 1, 2017. Crossref
-
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-
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-
Inoue Daisuke, Yamashita Ayari, To Hideto, Development of In Vitro Evaluation System for Assessing Drug Dissolution Considering Physiological Environment in Nasal Cavity, Pharmaceutics, 14, 11, 2022. Crossref
-
Alharbi Waleed S., Hareeri Rawan H., Bazuhair Mohammed, Alfaleh Mohamed A., Alhakamy Nabil A., Fahmy Usama A., Alamoudi Abdullah A., Badr-Eldin Shaimaa M., Ahmed Osama A., AlGhamdi Shareefa A., Naguib Marianne J., Spanlastics as a Potential Platform for Enhancing the Brain Delivery of Flibanserin: In Vitro Response-Surface Optimization and In Vivo Pharmacokinetics Assessment, Pharmaceutics, 14, 12, 2022. Crossref