Library Subscription: Guest
Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Cancer Stem Cells: Root of the Evil

Volume 24, Issue 1, 2019, pp. 69-87
DOI: 10.1615/CritRevOncog.2019029512
Get accessGet access

ABSTRACT

Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors (less than 0.1%), these cells determine the fate of cancer patients because of their roles in poor prognoses. Accumulating evidence has shown that CSCs are the major responsible cell population in tumor development, growth, metastasis, and therapy resistance. The self-renewal and differentiation capacity of CSCs contribute to the initiation and maintenance of tumor growth. Several reports indicate that CSCs share numerous molecular characteristics with mesenchymal cells, so CSCs are accepted as leading players in metastasis. In addition, these cells possess a higher intrinsic resistance to chemotherapies and radiotherapies than bulk cancer cells. Therefore, therapeutic approaches in recent years have focused on effectively targeting CSCs. Here, we have reviewed the current literature on the resistant mechanisms of CSCs, their roles in metastasis, and the roles of non-coding RNAs in the regulation of aggressive CSC characteristics and novel therapy approaches against CSCs.

CITED BY
  1. Wang Wen-Jun, Wang Jiao, Ouyang Chao, Chen Chong, Xu Xiao-Feng, Ye Xiao-Qun, Overview of serpin B9 and its roles in cancer (Review), Oncology Reports, 46, 3, 2021. Crossref

  2. Zając Agnieszka, Król Sylwia K., Rutkowski Piotr, Czarnecka Anna M., Biological Heterogeneity of Chondrosarcoma: From (Epi) Genetics through Stemness and Deregulated Signaling to Immunophenotype, Cancers, 13, 6, 2021. Crossref

  3. Wang Xuan, Cai Jun, Zhao Lei, Zhang Dejun, Xu Guojie, Hu Jianli, Zhang Tao, Jin Min, NUMB suppression by miR-9-5P enhances CD44+ prostate cancer stem cell growth and metastasis, Scientific Reports, 11, 1, 2021. Crossref

  4. Kilmister Ethan J., Tan Swee T., Cancer Stem Cells in the Head and Neck Cancers, in Atlas of Extreme Facial Cancer, 2022. Crossref

  5. Erkisa Merve, Sariman Melda, Geyik Oyku Gonul, Geyik Caner, Stanojkovic Tatjana, Ulukaya Engin, Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells, Current Medicinal Chemistry, 29, 4, 2022. Crossref

  6. Xiao Chanchan, Wu Guangjie, Chen Pengfei, Gao Lijuan, Chen Guobing, Zhang Hongyi, Phase separation in epigenetics and cancer stem cells, Frontiers in Oncology, 12, 2022. Crossref

  7. Zou Weiyan, Zhang Yi, Bai Guangfu, Zhuang Jialu, Wei Lin, Wang Zishu, Sun Meiqun, Wang Junbin, siRNA‐induced CD44 knockdown suppresses the proliferation and invasion of colorectal cancer stem cells through inhibiting epithelial–mesenchymal transition, Journal of Cellular and Molecular Medicine, 26, 7, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain