Library Subscription: Guest
Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?

Volume 20, Issue 3-4, 2015, pp. 155-171
DOI: 10.1615/CritRevOncog.2015013553
Get accessGet access

ABSTRACT

Ewing sarcoma (ES) is a highly aggressive bone and soft-tissue tumor with peak incidence among adolescents and young adults. Despite advances in local control and systemic chemotherapy, metastatic relapse after an initial clinical remission remains a significant clinical problem. In addition, metastasis at the time of presentation or at relapse continues to be the leading cause of death for patients diagnosed with ES. Since the discovery of the pathognomonic EWS−FLI1 fusion gene more than 20 years ago, much about the molecular and cellular biology of ES pathogenesis has been learned. In addition, more recent exploitation of advances in stem cell and developmental biology has provided key insights into the cellular origins of ES and the role of epigenetic deregulation in tumor initiation and maintenance. Nevertheless, the mechanisms that drive tumor relapse and metastasis remain largely unknown. These gaps in our knowledge continue to hamper the development of novel therapeutic strategies that may improve outcomes for patients with relapsed and metastatic disease. In this article we review the current status of ES biology research, highlighting areas of investigation that we consider to have the greatest potential to yield findings that will translate into clinically significant advances.

CITED BY
  1. Mutz Cornelia N., Schwentner Raphaela, Kauer Maximilian O., Katschnig Anna M., Kromp Florian, Aryee Dave N. T., Erhardt Sophie, Goiny Michel, Alonso Javier, Fuchs Dietmar, Kovar Heinrich, EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway, FEBS Letters, 590, 14, 2016. Crossref

  2. Grünewald Thomas G.P., Gilardi-Hebenstreit Pascale, Charnay Patrick, Delattre Olivier, Coopération entre mutation somatique et variant génétique de susceptibilité dans le sarcome d’Ewing, médecine/sciences, 32, 4, 2016. Crossref

  3. Barr Frederic G., Fusion genes in solid tumors: the possibilities and the pitfalls, Expert Review of Molecular Diagnostics, 16, 9, 2016. Crossref

  4. López Sosa Francisco H., Valadez María Teresa, Contreras Luis Cruz, Perezpeña-Diazconti Mario, Sarcoma de Ewing extraóseo en una adolescente de 16 años, Boletín Médico del Hospital Infantil de México, 73, 3, 2016. Crossref

  5. Park Hyewon, Galbraith Richard, Turner Thaddeus, Mehojah Justin, Azuma Mizuki, Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish, Scientific Reports, 6, 1, 2016. Crossref

  6. Bailey Kelly M., Airik Merlin, Krook Melanie A., Pedersen Elisabeth A., Lawlor Elizabeth R., Micro-Environmental Stress Induces Src-Dependent Activation of Invadopodia and Cell Migration in Ewing Sarcoma, Neoplasia, 18, 8, 2016. Crossref

  7. Åman Pierre, Dolatabadi Soheila, Svec David, Jonasson Emma, Safavi Setareh, Andersson Daniel, Grundevik Pernilla, Thomsen Christer, Ståhlberg Anders, Regulatory mechanisms, expression levels and proliferation effects of theFUS-DDIT3fusion oncogene in liposarcoma, The Journal of Pathology, 238, 5, 2016. Crossref

  8. Jacobs Andrew J., Fishbein Joanna, Levy Carolyn Fein, Glick Richard D., Chest wall Ewing sarcoma: a population-based analysis, Journal of Surgical Research, 204, 2, 2016. Crossref

  9. Katschnig A M, Kauer M O, Schwentner R, Tomazou E M, Mutz C N, Linder M, Sibilia M, Alonso J, Aryee D N T, Kovar H, EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma, Oncogene, 36, 43, 2017. Crossref

  10. López Sosa Francisco H., Valadez María Teresa, Cruz Contreras Luis, Perezpeña-Diazconti Mario, Extraskeletal Ewing sarcoma in a 16-year-old female adolescent, Boletín Médico Del Hospital Infantil de México (English Edition), 73, 3, 2016. Crossref

  11. Kovar Heinrich, Ewing Sarcoma, in Encyclopedia of Cancer, 2015. Crossref

  12. Rochefort Pauline, Italiano Antoine, Laurence Valérie, Penel Nicolas, Lardy-Cleaud Audrey, Mir Olivier, Chevreau Christine, Bertucci Francois, Bompas Emmanuelle, Chaigneau Loic, Levy Dominique, Ryckewaert Thomas, Dumont Sarah, Meeus Pierre, Ranchere Dominique, Blay Jean-Yves, Cassier Philippe Alexandre, A Retrospective Multicentric Study of Ewing Sarcoma Family of Tumors in Patients Older Than 50: Management and Outcome, Scientific Reports, 7, 1, 2017. Crossref

  13. Villasante Aranzazu, Marturano-Kruik Alessandro, Robinson Samuel T., Liu Zen, Guo X. Edward, Vunjak-Novakovic Gordana, Tissue-Engineered Model of Human Osteolytic Bone Tumor, Tissue Engineering Part C: Methods, 23, 2, 2017. Crossref

  14. Choo Sun, Wang Ping, Newbury Robert, Roberts William, Yang Jing, Reactivation of TWIST1 contributes to Ewing sarcoma metastasis, Pediatric Blood & Cancer, 65, 1, 2018. Crossref

  15. Hawkins Allegra G., Basrur Venkatesha, da Veiga Leprevost Felipe, Pedersen Elisabeth, Sperring Colin, Nesvizhskii Alexey I., Lawlor Elizabeth R., The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling, Molecular & Cellular Proteomics, 17, 5, 2018. Crossref

  16. Schifflers Stefan, Delbecque Katty, Galant Christine, Francotte Nadine, Philippet Pierre, Chantrain Christophe F., Microscopic Infiltration of Cryopreserved Ovarian Tissue in 2 Patients With Ewing Sarcoma, Journal of Pediatric Hematology/Oncology, 40, 3, 2018. Crossref

  17. Çelik Haydar, Sciandra Marika, Flashner Bess, Gelmez Elif, Kayraklıoğlu Neslihan, Allegakoen David V., Petro Jeff R., Conn Erin J., Hour Sarah, Han Jenny, Oktay Lalehan, Tiwari Purushottam B., Hayran Mutlu, Harris Brent T., Manara Maria Cristina, Toretsky Jeffrey A., Scotlandi Katia, Üren Aykut, Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99, Oncogene, 37, 16, 2018. Crossref

  18. Cossetti Cristina, Gualtieri Alberto, Pomella Silvia, Carcarino Elena, Rota Rossella, Notch Signaling in Pediatric Soft Tissue Sarcoma, in Targeting Notch in Cancer, 2018. Crossref

  19. Dixon Stephanie B., Force Lisa M., Bandopadhayay Pratiti, Manley Peter, Rodriguez-Galindo Carlos, Silverman Lewis B., Marcus Karen J., Pediatric Cancers, in The American Cancer Society's Oncology in Practice, 2018. Crossref

  20. Svoboda Laurie K, Teh Selina Shiqing K, Sud Sudha, Kerk Samuel, Zebolsky Aaron, Treichel Sydney, Thomas Dafydd, Halbrook Christopher J, Lee Ho-Joon, Kremer Daniel, Zhang Li, Klossowski Szymon, Bankhead Armand R, Magnuson Brian, Ljungman Mats, Cierpicki Tomasz, Grembecka Jolanta, Lyssiotis Costas A, Lawlor Elizabeth R, Menin regulates the serine biosynthetic pathway in Ewing sarcoma, The Journal of Pathology, 245, 3, 2018. Crossref

  21. Kovar Heinrich, Ewing Sarcoma, in Encyclopedia of Cancer, 2015. Crossref

  22. Stahl David, Gentles Andrew J, Thiele Ralf, Gütgemann Ines, Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors, OncoImmunology, 8, 12, 2019. Crossref

  23. Galardi Angela, Colletti Marta, Di Paolo Virginia, Vitullo Patrizia, Antonetti Loretta, Russo Ida, Di Giannatale Angela, Exosomal MiRNAs in Pediatric Cancers, International Journal of Molecular Sciences, 20, 18, 2019. Crossref

  24. Bailey Kelly, Cost Carrye, Davis Ian, Glade-Bender Julia, Grohar Patrick, Houghton Peter, Isakoff Michael, Stewart Elizabeth, Laack Nadia, Yustein Jason, Reed Damon, Janeway Katherine, Gorlick Richard, Lessnick Stephen, DuBois Steven, Hingorani Pooja, Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task Force, F1000Research, 8, 2019. Crossref

  25. MacDonald David, Radiopacities, in Oral and Maxillofacial Radiology, 2019. Crossref

  26. Pfaltzgraff Elise, Apfelbaum April, Kassa Andrew, Song Jane, Jiang Wei, Suhan Tahra, Wellik Deneen, Lawlor Elizabeth, Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation, Cancers, 11, 3, 2019. Crossref

  27. Issaq Sameer H., Mendoza Arnulfo, Fox Stephen D., Helman Lee J., Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth, Oncogenesis, 8, 3, 2019. Crossref

  28. He Shaohui, Huang Quan, Hu Jinbo, Li Lei, Xiao Yanbin, Yu Hongyu, Han Zhitao, Wang Ting, Zhou Wang, Wei Haifeng, Xiao Jianru, EWS-FLI1-mediated tenascin-C expression promotes tumour progression by targeting MALAT1 through integrin α5β1-mediated YAP activation in Ewing sarcoma, British Journal of Cancer, 121, 11, 2019. Crossref

  29. Hawkins Allegra G., Julian Claire M., Konzen Sonja, Treichel Sydney, Lawlor Elizabeth R., Bailey Kelly M., Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma, Neoplasia, 21, 10, 2019. Crossref

  30. Krook Melanie A., Hawkins Allegra G., Patel Rajiv M., Lucas David R., Van Noord Raelene, Chugh Rashmi, Lawlor Elizabeth R., A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma, Oncotarget, 7, 38, 2016. Crossref

  31. Hayashi Masanori, Baker Alissa, Goldstein Seth D., Albert Catherine M., Jackson Kyle W., McCarty Gregory, Kahlert Ulf D., Loeb David M., Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma, Oncotarget, 8, 45, 2017. Crossref

  32. Bailey Kelly M., Prospective investigation of drug resistance: an approach to understanding and optimizing the clinical benefit of targeted agents in Ewing sarcoma, Oncotarget, 9, 99, 2018. Crossref

  33. Houdek Matthew T., Inwards Carrie Y., Tumors of the Pelvis: Pathologic Aspect, in Surgery of the Pelvic and Sacral Tumor, 2020. Crossref

  34. Bailey Kelly M., Julian Claire M., Klinghoffer Ariel N., Bernard Heather, Lucas Peter C., McAllister-Lucas Linda M., EWS-FLI1 low Ewing sarcoma cells demonstrate decreased susceptibility to T-cell-mediated tumor cell apoptosis, Oncotarget, 10, 36, 2019. Crossref

  35. Gargallo P., Juan A., Yáñez Y., Dolz S., Segura V., Castel V., Cañete A., Precision medicine in Ewing sarcoma: a translational point of view, Clinical and Translational Oncology, 22, 9, 2020. Crossref

  36. Jacoby Josephine M., Strakeljahn Silas, Nitsch Andreas, Bekeschus Sander, Hinz Peter, Mustea Alexander, Ekkernkamp Axel, Tzvetkov Mladen V., Haralambiev Lyubomir, Stope Matthias B., An Innovative Therapeutic Option for the Treatment of Skeletal Sarcomas: Elimination of Osteo- and Ewing’s Sarcoma Cells Using Physical Gas Plasma, International Journal of Molecular Sciences, 21, 12, 2020. Crossref

  37. Parrish Janet K., McCann Tyler S., Sechler Marybeth, Sobral Lays M., Ren Wenhua, Jones Kenneth L., Tan Aik Choon, Jedlicka Paul, The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth, Oncotarget, 9, 69, 2018. Crossref

  38. Jayabal Panneerselvam, Houghton Peter J., Shiio Yuzuru, EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1 , Genes & Cancer, 8, 11-12, 2017. Crossref

  39. Hawkins Allegra G., Pedersen Elisabeth A., Treichel Sydney, Temprine Kelsey, Sperring Colin, Read Jay A., Magnuson Brian, Chugh Rashmi, Lawlor Elizabeth R., Wnt/β-catenin–activated Ewing sarcoma cells promote the angiogenic switch, JCI Insight, 5, 13, 2020. Crossref

  40. Hernandez Tejada Fiorela N., Zamudio Alejandro, Marques-Piubelli Mario L., Cuglievan Branko, Harrison Douglas, Advances in the Management of Pediatric Sarcomas, Current Oncology Reports, 23, 1, 2021. Crossref

  41. Mancarella Caterina, Caldoni Giulia, Ribolsi Irene, Parra Alessandro, Manara Maria Cristina, Mercurio Arthur M., Morrione Andrea, Scotlandi Katia, Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis, Frontiers in Oncology, 10, 2020. Crossref

  42. McCann Tyler S., Parrish Janet K., Hsieh Joseph, Sechler Marybeth, Sobral Lays M., Self Chelsea, Jones Kenneth L., Goodspeed Andrew, Costello James C., Jedlicka Paul, KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma, Oncotarget, 11, 43, 2020. Crossref

  43. Kit O. I., Yurchenko D. Yu., Ulyanova E. P., Burtsev D. V., Kuznetsov S. A., Sagakyants A. B., Frantsiyants E. M., Mkrtchyan G. A., Pak E. Ye., Starzhetskaya M. V., Bespalova A. I., Popovyan O. P., ZEB1 as an additional predictor of tumor progression in Ewingʼs sarcoma. Results of a morphological study on a population of children and adolescents, Russian Journal of Pediatric Hematology and Oncology, 7, 3, 2020. Crossref

  44. Wingerter Arthur, El Malki Khalifa, Sandhoff Roger, Seidmann Larissa, Wagner Daniel-Christoph, Lehmann Nadine, Vewinger Nadine, Frauenknecht Katrin B. M., Sommer Clemens J., Traub Frank, Kindler Thomas, Russo Alexandra, Otto Henrike, Lollert André, Staatz Gundula, Roth Lea, Paret Claudia, Faber Jörg, Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma, Cancers, 13, 3, 2021. Crossref

  45. Villasante Aranzazu, Robinson Samuel T., Cohen Andrew R., Lock Roberta, Guo X. Edward, Vunjak-Novakovic Gordana, Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer, Frontiers in Bioengineering and Biotechnology, 9, 2021. Crossref

  46. Morales Erin, Olson Michael, Iglesias Fiorella, Luetkens Tim, Atanackovic Djordje, Targeting the tumor microenvironment of Ewing sarcoma, Immunotherapy, 13, 17, 2021. Crossref

  47. Jayabal Panneerselvam, Zhou Fuchun, Lei Xiufen, Ma Xiuye, Blackman Barron, Weintraub Susan T., Houghton Peter J., Shiio Yuzuru, NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth, Cell Reports, 36, 1, 2021. Crossref

  48. Richter Günther, Lissat Andrej, Kontny Udo, Regulated cell death and drug resistance in malignant bone tumors, in Bone Cancer, 2022. Crossref

  49. Shoeib Amal M., Yarbrough Azure L., Ford Benjamin M., Franks Lirit N., Urbaniak Alicja, Hensley Lori L., Benson Lance N., Mu Shengyu, Radominska-Pandya Anna, Prather Paul L., Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development, Life Sciences, 285, 2021. Crossref

  50. Sinichenkova K. Y., Roschin V. Y., Druy A. E., Molecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue, Bone and soft tissue sarcomas, tumors of the skin, 13, 1, 2021. Crossref

  51. Polski Ashley, Berry Jesse L., Gombos Dan S., Ophthalmological Manifestations of Systemic Neoplasia and Its Treatment, in Albert and Jakobiec's Principles and Practice of Ophthalmology, 2021. Crossref

  52. Chen Yi, Su Huafang, Su Yanhong, Zhang Yifan, Lin Yingbo, Haglund Felix, Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma, Cancers, 13, 15, 2021. Crossref

  53. Weaver Davis T., Pishas Kathleen I., Williamson Drew, Scarborough Jessica, Lessnick Stephen L., Dhawan Andrew, Scott Jacob G., Zhang Zhaolei, Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma, PLOS Computational Biology, 17, 10, 2021. Crossref

  54. Park Hyewon, Kim Haeyoung, Hassebroek Victoria, Azuma Yoshiaki, Slawson Chad, Azuma Mizuki, Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy, Journal of Biological Chemistry, 296, 2021. Crossref

  55. Pachva Manideep C., Lai Horton, Jia Andy, Rouleau Melanie, Sorensen Poul H., Extracellular Vesicles in Reprogramming of the Ewing Sarcoma Tumor Microenvironment, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  56. Bierbaumer Lisa, Katschnig Anna M., Radic-Sarikas Branka, Kauer Maximilian O., Petro Jeffrey A., Högler Sandra, Gurnhofer Elisabeth, Pedot Gloria, Schäfer Beat W., Schwentner Raphaela, Mühlbacher Karin, Kromp Florian, Aryee Dave N. T., Kenner Lukas, Uren Aykut, Kovar Heinrich, YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells, Oncogenesis, 10, 1, 2021. Crossref

  57. Markey Fatu Badiane, Romero Brigette, Parashar Vijay, Batish Mona, Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing’s Sarcoma, Cells, 10, 6, 2021. Crossref

  58. Lanzi Cinzia, Cassinelli Giuliana, Combinatorial strategies to potentiate the efficacy of HDAC inhibitors in fusion-positive sarcomas, Biochemical Pharmacology, 198, 2022. Crossref

  59. Issaq Sameer H., Mendoza Arnulfo, Kidner Ria, Rosales Tracy I., Duveau Damien Y., Heske Christine M., Rohde Jason M., Boxer Matthew B., Thomas Craig J., DeBerardinis Ralph J., Helman Lee J., EWS-FLI1–regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth, Molecular Cancer Therapeutics, 19, 7, 2020. Crossref

  60. Martin Jeffrey C., Hoegel Tamara J., Lynch Miranda L., Woloszynska Anna, Melendy Thomas, Ohm Joyce E., Exploiting Replication Stress as a Novel Therapeutic Intervention, Molecular Cancer Research, 19, 2, 2021. Crossref

  61. Polski Ashley, Berry Jesse L., Gombos Dan S., Ophthalmological Manifestations of Systemic Neoplasia and Its Treatment, in Albert and Jakobiec's Principles and Practice of Ophthalmology, 2022. Crossref

  62. Yoshimoto Toyoki, Tanaka Miwa, Homme Mizuki, Yamazaki Yukari, Takazawa Yutaka, Antonescu Cristina R., Nakamura Takuro, CIC-DUX4 Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma, Cancer Research, 77, 11, 2017. Crossref

  63. Jiménez Jennifer A., Apfelbaum April A., Hawkins Allegra G., Svoboda Laurie K., Kumar Abhijay, Ruiz Ramon Ocadiz, Garcia Alessandra X., Haarer Elena, Nwosu Zeribe C., Bradin Joshua, Purohit Trupta, Chen Dong, Cierpicki Tomasz, Grembecka Jolanta, Lyssiotis Costas A., Lawlor Elizabeth R., EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma, Molecular Cancer Research, 19, 7, 2021. Crossref

  64. Galembikova A., Boichuk S., Targeting of AKT-Signaling Pathway Potentiates the Anti-cancer Efficacy of Doxorubicin in A673 Ewing Sarcoma Cell Line, BioNanoScience, 11, 4, 2021. Crossref

  65. Zhou Fuchun, Elzi David J., Jayabal Panneerselvam, Ma Xiuye, Chiu Yu-Chiao, Chen Yidong, Blackman Barron, Weintraub Susan T., Houghton Peter J., Shiio Yuzuru, GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth, Cell Reports, 33, 5, 2020. Crossref

  66. Pan Bin, Bu Xiangbo, Cao Menghan, Zhang Xin, Huo Tianqun, Li Ziang, Gao Xiao, Jing Li, Luo Xuanxiang, Feng Hu, Yuan Feng, Guo Kaijin, Inactivation of ICAM1 inhibits metastasis and improves the prognosis of Ewing's sarcoma, Journal of Cancer Research and Clinical Oncology, 147, 2, 2021. Crossref

  67. Stefani Rodrigo Rosa de , Toni Elisa Cristina de , Farias Caroline Brunetto de , Brunetto André Tesainer , Brunetto Algemir Lunardi , Roesler Rafael, Alho Clarice Sampaio , Friedrich Deise Cristine , GGAA microsatellites of NR0B1 promoter region in Ewing's sarcoma patients and healthy individuals from a south Brazilian population, Revista Brasileira de Cancerologia, 68, 2, 2022. Crossref

  68. Yeung Choh, Gibson Anna E., Issaq Sameer H., Oshima Nobu, Baumgart Joshua T., Edessa Leah D., Rai Ganesha, Urban Daniel J., Johnson Michelle S., Benavides Gloria A., Squadrito Giuseppe L., Yohe Marielle E., Lei Haiyan, Eldridge Sandy, Hamre John, Dowdy Tyrone, Ruiz-Rodado Victor, Lita Adrian, Mendoza Arnulfo, Shern Jack F., Larion Mioara, Helman Lee J., Stott Gordon M., Krishna Murali C., Hall Matthew D., Darley-Usmar Victor, Neckers Leonard M., Heske Christine M., Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma, Cancer Research, 79, 19, 2019. Crossref

  69. Pedersen Elisabeth A., Menon Rajasree, Bailey Kelly M., Thomas Dafydd G., Van Noord Raelene A., Tran Jenny, Wang Hongwei, Qu Ping Ping, Hoering Antje, Fearon Eric R., Chugh Rashmi, Lawlor Elizabeth R., Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States, Cancer Research, 76, 17, 2016. Crossref

  70. Henrich Ian C., Jain Kanika, Young Robert, Quick Laura, Lindsay Jarrett M., Park Daniel H., Oliveira Andre M., Blobel Gerd A., Chou Margaret M., Ubiquitin-Specific Protease 6 Functions as a Tumor Suppressor in Ewing Sarcoma through Immune Activation, Cancer Research, 81, 8, 2021. Crossref

  71. Li Mingli, Chen Chunwei, Regulation of Metastasis in Ewing Sarcoma, Cancers, 14, 19, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain