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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Mechanism and Regulation of Autophagy in Cancer

Volume 23, Issue 5-6, 2018, pp. 269-280
DOI: 10.1615/CritRevOncog.2018028394
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ABSTRACT

Autophagy, or self-eating, is a catabolic process that plays a crucial role in cellular homeostasis by carrying out bulk degradation of defective or superfluous proteins as well as worn-out organelles through a specialized structure, the autophagosome, which in turn fuses with the lysosome. Autophagy also alleviates cellular stress induced by nutrient deprivation, metabolic disturbance, hypoxia, and the like, by recycling intracellular constituents. This role of autophagy, to provide metabolic precursors especially upon starvation, might also contribute to the survival of cancer cells. The role of autophagy in cancer cells is ambiguous given that its downregulation or upregulation has been observed to depend on cancer stage and pathological grade. Autophagy has been found to exhibit a dual effect on tumorigenesis where it functions to suppress tumor progression by eliminating factors that cause genome instability while promoting survival of cancer cells under unfavorable conditions like therapeutic stress. This review aims to explain the mechanism, regulation, and the dual role of autophagy in cancer.

CITED BY
  1. Huang Wenyuan, Liang Yan, Ma Xiaofeng, Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells, Cancer Cell International, 19, 1, 2019. Crossref

  2. Vartanian A. A., Khochenkov D. A., Kosobokova E. N., Kosorukov V. S., CROSSTALK BETWEEN AUTOPHAGY AND APOPTOSIS IN CD437-INDUCED А549 LUNG CARCINOMA CELL DEATH, Russian Journal of Biotherapy, 19, 4, 2020. Crossref

  3. Liu Xianfang, Suo Huiyuan, Zhou Shengli, Hou Zhenxing, Bu Mingqiang, Liu Xiuxiu, Xu Wei, Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells, Cell Death & Disease, 12, 8, 2021. Crossref

  4. Guo Hengjuan, Ding Hui, Tang Xin, Liang Maoli, Li Shuo, Zhang Jing, Cao Jie, Quercetin induces pro‐apoptotic autophagy via SIRT1 / AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro , Thoracic Cancer, 12, 9, 2021. Crossref

  5. Li Lunxu, Xia Shilin, Shi Xueying, Chen Xu, Shang Dong, The novel immune-related genes predict the prognosis of patients with hepatocellular carcinoma, Scientific Reports, 11, 1, 2021. Crossref

  6. Wu Xiaofeng, Zhu Jing, Liu Wei, Jin Meng, Xiong Mengqing, Hu Ke, A Novel Prognostic and Predictive Signature for Lung Adenocarcinoma Derived from Combined Hypoxia and Infiltrating Immune Cell-Related Genes in TCGA Patients, International Journal of General Medicine, Volume 14, 2021. Crossref

  7. Mengual Daniela, Medrano Luz Elena, Villamizar-Villamizar Wendy, Osorio-Llanes Estefanie, Mendoza-Torres Evelyn, Bolívar Samir, Novel Effects of Statins on Cancer via Autophagy, Pharmaceuticals, 15, 6, 2022. Crossref

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