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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Human Prostate Carcinogenesis

Volume 8, Issue 4, 1997, pp. 305-328
DOI: 10.1615/CritRevOncog.v8.i4.20
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ABSTRACT

Prostate cancer is a major medical problem that is expected to affect over 300,000 American men and cause over 40,000 deaths in 1997. Despite its widespread prevalence and because of the difficulties in clinical diagnosis and treatment of the disease, the etiological mechanism underlying prostate carcinogenesis remains poorly understood. Elucidation of the mechanism of prostate tumorigenesis has been slowed by a lack of tumor tissues and the limited number of human cell lines available for study. In vitro human cell models to study the molecular biology of prostate cancer progression are urgently needed. Normal human prostate cells require immortalization to provide a practical system for transformation studies. Neoplastic transformation of human prostate epithelial cells in culture has been achieved recently in a stepwise fashion—immortalization of primary cells in culture and conversion of the immortalized cells to a tumorigenic state. Reviewed here are the steps involved in the neoplastic transformation of human prostate cells. To provide an insight into the molecular and genetic mechanisms involved in the conversion of normal cells to a neoplastic state of growth, the authors have attempted to put into perspective the history of human prostate epithelial cell transformation by a combination of carcinogenic agents, and to discuss the current state-of-the-art in transformation of human prostate epithelial cells in culture.

CITED BY
  1. Walker-Daniels J., Coffman K., Azimi M., Rhim J.S., Bostwick D.G., Snyder P., Kerns B.J., Waters D.J., Kinch M.S., Overexpression of the EphA2 tyrosine kinase in prostate cancer, The Prostate, 41, 4, 1999. Crossref

  2. YEH JIUN-YIH, HUANG WILLIAM J., KAN SHU-FEN, WANG PAULUS S., INHIBITORY EFFECTS OF DIGITALIS ON THE PROLIFERATION OF ANDROGEN DEPENDENT AND INDEPENDENT PROSTATE CANCER CELLS, The Journal of Urology, 2001. Crossref

  3. Yeh Jiun-Yih, Huang William J., Kan Shu-Fen, Wang Paulus S., Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells, The Prostate, 54, 2, 2003. Crossref

  4. Chen Mei-Chih, Huang Chih-Yang, Hsu Shih-Lan, Lin Eugene, Ku Chien-Te, Lin Ho, Chen Chuan-Mu, Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation, Evidence-Based Complementary and Alternative Medicine, 2012, 2012. Crossref

  5. Tremblay C., Dore M., Bochsler P. N., Sirois J., Induction of Prostaglandin G/H Synthase-2 in a Canine Model of Spontaneous Prostatic Adenocarcinoma, JNCI Journal of the National Cancer Institute, 91, 16, 1999. Crossref

  6. YEH JIUN-YIH, HUANG WILLIAM J., KAN SHU-FEN, WANG PAULUS S., INHIBITORY EFFECTS OF DIGITALIS ON THE PROLIFERATION OF ANDROGEN DEPENDENT AND INDEPENDENT PROSTATE CANCER CELLS, Journal of Urology, 166, 5, 2001. Crossref

  7. Hsu Fu-Ning, Yang Min-Shiou, Lin Eugene, Tseng Chun-Fu, Lin Ho, The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells, American Journal of Physiology-Endocrinology and Metabolism, 300, 5, 2011. Crossref

  8. Hsu Fu-Ning, Chen Mei-Chih, Chiang Ming-Ching, Lin Eugene, Lee Yueh-Tsung, Huang Pao-Hsuan, Lee Guan-Shun, Lin Ho, Regulation of Androgen Receptor and Prostate Cancer Growth by Cyclin-dependent Kinase 5, Journal of Biological Chemistry, 286, 38, 2011. Crossref

  9. Lin Ho, Juang Jyh-Lyh, Wang Paulus S., Involvement of Cdk5/p25 in Digoxin-triggered Prostate Cancer Cell Apoptosis, Journal of Biological Chemistry, 279, 28, 2004. Crossref

  10. Kim Hyun-Sook, Lee Eun-Hee, Ko Sung-Ryong, Choi Kang-Ju, Park Jong-Hee, Im Dong-Soon, Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells, Archives of Pharmacal Research, 27, 4, 2004. Crossref

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