Published 4 issues per year
ISSN Print: 0893-9675
ISSN Online: 2162-6448
Indexed in
Functional Role of MicroRNAs in Prostate Cancer and Therapeutic Opportunities
ABSTRACT
Prostate cancer is one of the most common causes of cancer-related death. The management of prostate cancer patients has become increasingly complex, consequently calling on the need for identifying and validating prognostic and predictive biomarkers. Growing evidence indicates that microRNAs play a crucial role in the pathobiology of neoplastic diseases. The deregulation of the cellular "miRNome" in prostate cancer has been connected with multiple tumor-promoting activities such as aberrant activation of growth signals, anti-apoptotic effects, prometastatic mechanisms, alteration of the androgen receptor pathway, and regulation of the cancer stem cell phenotype. With the elucidation of molecular mechanisms controlled by microRNAs, investigations have been conducted in an attempt to exploit these molecules in the clinical setting. Moreover, the multifaceted biological activity of microRNAs makes them an attractive candidate as anticancer agents. This review summarizes the current knowledge on microRNA deregulation in prostate cancer, and the rationale underlying their exploitation as cancer biomarkers and therapeutics.
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Kang Shaosan, Zhao Yansheng, Hu Kaimeng, Xu Chen, Wang Lei, Liu Jian, Yao Anliang, Zhang Hongmei, Cao Fenghong, miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway, The Prostate, 74, 11, 2014. Crossref
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Stegeman Shane, Moya Leire, Selth Luke A, Spurdle Amanda B, Clements Judith A, Batra Jyotsna, A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer, Endocrine-Related Cancer, 22, 2, 2015. Crossref
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Chang Yung-Sheng, Chen Wei-Yu, Yin Juan Juan, Sheppard-Tillman Heather, Huang Jiaoti, Liu Yen-Nien, EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1, Cancer Research, 75, 15, 2015. Crossref
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Liu Yen-Nien, Yin JuanJuan, Barrett Ben, Sheppard-Tillman Heather, Li Dongmei, Casey Orla M., Fang Lei, Hynes Paul G., Ameri Amir H., Kelly Kathleen, Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis, Molecular and Cellular Biology, 35, 11, 2015. Crossref