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Critical Reviews™ in Oncogenesis

Published 4 issues per year

ISSN Print: 0893-9675

ISSN Online: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Epigenetic Modifications and Modulators in Prostate Cancer

Volume 22, Issue 5-6, 2017, pp. 439-450
DOI: 10.1615/CritRevOncog.2017020964
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ABSTRACT

Prostate cancer (PCa) is one of the most common malignancies in men. Its clinical behavior ranges from indolent to aggressive. The clinical and morphological methods and features currently adopted show a low predictive value concerning the definition of its level of aggressiveness. Investigations have been led to understand its complex genomic landscape to improve diagnosis and prognosis as well as to define the potential role of new therapeutic targets. Epigenetic changes, including modifications in DNA methylation and histone acetylation, can contribute to the clinical behavior of PCa. MicroRNAs (miRNAs) can be used as potential biomarkers in the definition of PCa. The reversibility of epigenetic modifications opens the door to a potential perspective in the development of epigenetics modulators. The scope of this contribution is to review the main epigenetic modifications identified in PCa, including research on epigenetic modifiers and modulators.

CITED BY
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  2. Fu Weiwei, Li Hong, Fu Haiyang, Zhao Shuchao, Shi Weiping, Sun Mengqi, Li Yujun, Song Jian, The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response, Journal of Immunology Research, 2020, 2020. Crossref

  3. Corno Cristina, Arrighetti Noemi, Ciusani Emilio, Corna Elisabetta, Carenini Nives, Zaffaroni Nadia, Gatti Laura, Perego Paola, Synergistic Interaction of Histone Deacetylase 6- and MEK-Inhibitors in Castration-Resistant Prostate Cancer Cells, Frontiers in Cell and Developmental Biology, 8, 2020. Crossref

  4. Macedo-Silva Catarina, Benedetti Rosaria, Ciardiello Fortunato, Cappabianca Salvatore, Jerónimo Carmen, Altucci Lucia, Epigenetic mechanisms underlying prostate cancer radioresistance, Clinical Epigenetics, 13, 1, 2021. Crossref

  5. Li Ting, Liu Nanjing, Gao Yingying, Quan Zhen, Hao Yanni, Yu Chaowen, Li Luo, Yuan Mengjuan, Niu Lingfang, Luo Chunli, Wu Xiaohou, Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM, British Journal of Cancer, 124, 1, 2021. Crossref

  6. Mokoala Kgomotso, Lawal Ismaheel, Lengana Thabo, Kgatle Mankgopo, Giesel Frederik L., Vorster Mariza, Sathekge Mike, PSMA Theranostics: Science and Practice, Cancers, 13, 15, 2021. Crossref

  7. Wan Hongyuan, Feng Yanyan, Wu Junjie, Zhu Lijie, Mi Yuanyuan, Functions and mechanisms of N6‑methyladenosine in prostate cancer (Review), Molecular Medicine Reports, 26, 3, 2022. Crossref

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