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Critical Reviews™ in Biomedical Engineering

Published 6 issues per year

ISSN Print: 0278-940X

ISSN Online: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Role of Substrates in Diabetes Therapy:Stem Cell Differentiation and Islet Transplantation

Volume 39, Issue 6, 2011, pp. 535-555
DOI: 10.1615/CritRevBiomedEng.v39.i6.40
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ABSTRACT

Type 1 diabetes affects more than a million people in the United States and many more across the world. While pharmaceutical interventions and insulin supplementation are the most commonplace treatment of diabetes, these are not essentially cures and can potentially lead to long-term complications. Transplantation of insulin-producing Islets of Langerhans from donor pancreas has been established as a promising alternative to diabetes therapy. While successful islet transplantation has the potential of providing a cure, the primary hurdles to be overcome for it to be clinically viable are the scarcity of donor islets and immune rejection of transplanted islets. Recent advances in stem cell culture and differentiation techniques have established stem cells as a likely source of transplantable islets. Different stem cell sources have been induced toward pancreatic differentiation using specific chemical perturbations along with use of specific substrates. An approach to overcoming the second hurdle of immune rejection of transplantable islets is to encapsulate the islets in specific biomaterials. In this review, we discuss the extensive use of various substrates for pancreatic differentiation of different stem cell sources, along with different biomaterial designs used for islet transplantation.

CITED BY
  1. Krishnan Rahul, Arora Rajan P., Alexander Michael, White Sean M., Lamb Morgan W., Foster Clarence E., Choi Bernard, Lakey Jonathan R.T., Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model, Biomaterials, 35, 3, 2014. Crossref

  2. Dong Xingyou, Zhang Teng, Liu Qian, Zhu Jingzhen, Zhao Jiang, Li Jia, Sun Bishao, Ding Guolin, Hu Xiaoyan, Yang Zhenxing, Zhang Yuanyuan, Li Longkun, Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells, Molecular and Cellular Endocrinology, 427, 2016. Crossref

  3. Kaya‐Sezginer Ecem, Yilmaz‐Oral Didem, Gur Serap, Administration of human umbilical cord blood mononuclear cells restores bladder dysfunction in streptozotocin‐induced diabetic rats, LUTS: Lower Urinary Tract Symptoms, 11, 4, 2019. Crossref

  4. Mu Yongxu, Hao Zhiming, He Junfeng, Yan Ruiqiang, Liu Haiyan, Zhang Lei, Liu Heming, Hu Xiaoyan, Li Qiming, Effects of β-like cell autotransplantation through hepatic arterial intervention on diabetic dogs, Artificial Cells, Nanomedicine, and Biotechnology, 44, 5, 2016. Crossref

  5. Goh Saik-Kia, Halfter Willi, Richardson Thomas, Bertera Suzanne, Vaidya Vimal, Candiello Joe, Bradford Mahalia, Banerjee Ipsita, Organ-specific ECM arrays for investigating cell-ECM interactions during stem cell differentiation, Biofabrication, 13, 1, 2021. Crossref

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