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Plasma Medicine

Published 4 issues per year

ISSN Print: 1947-5764

ISSN Online: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

Indexed in

Cold Spark Discharge Plasma Treatment of Inflammatory Bowel Disease in an Animal Model of Ulcerative Colitis

Volume 1, Issue 1, 2011, pp. 3-19
DOI: 10.1615/PlasmaMed.v1.i1.10
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ABSTRACT

Cold plasma discharges have been shown to have medically-relevant therapeutic effects when applied to living tissues, including blood coagulation and wound healing; thus, plasma treatment of inflamed tissues in ulcerative colitis disease may be an effective approach to reduce adverse consequences if not cure the disease. Here we discuss results of the first experimental study of cold plasma treatment of ulcerative colitis in a mouse model. As a plasma source, a cold spark discharge has been used. The results show that plasma treatment of experimental model of ulcerative colitis in mice has some beneficial effects by suppressing the progression of the disease while no damage to colon tissues is observed; and these effects are comparable to standard therapy.

CITED BY
  1. Dobrynin D, Arjunan K, Fridman A, Friedman G, Clyne A Morss, Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma, Journal of Physics D: Applied Physics, 44, 7, 2011. Crossref

  2. Robert E., Vandamme M., Brullé L., Lerondel S., Le Pape A., Sarron V., Riès D., Darny T., Dozias S., Collet G., Kieda C., Pouvesle J.M., Perspectives of endoscopic plasma applications, Clinical Plasma Medicine, 1, 2, 2013. Crossref

  3. References, in Plasma Medicine, 2013. Crossref

  4. Liu Jiahui, Wang Ruixue, Yuan Hongyang, Cai Wenchao, Wang Xiaoying, Zhang Jue, Fang Jing, MRI-Guided Dielectric Barrier Discharge Plasma In Vivo: A Preliminary Study for Rectal Wall of Rabbit, Plasma Processes and Polymers, 11, 12, 2014. Crossref

  5. Dubinov Alexander E., Kozhayeva Julia P., Generation of Nanosecond Spark Microdischarges Along the Surface of Wings of Flying Insects, IEEE Transactions on Plasma Science, 42, 8, 2014. Crossref

  6. Malik Muhammad Arif, Jiang Chunqi, Heller Richard, Lane Jamie, Hughes David, Schoenbach Karl H., Ozone-free nitric oxide production using an atmospheric pressure surface discharge – A way to minimize nitrogen dioxide co-production, Chemical Engineering Journal, 283, 2016. Crossref

  7. Malik Muhammad Arif, Nitric Oxide Production by High Voltage Electrical Discharges for Medical Uses: A Review, Plasma Chemistry and Plasma Processing, 36, 3, 2016. Crossref

  8. Bazaka Kateryna, Grant Daniel S., Alancherry Surjith, Jacob Mohan V., Plasma-Assisted Fabrication and Processing of Biomaterials, in Biomedical Applications of Polymeric Materials and Composites, 2016. Crossref

  9. Weiss Martin, Gümbel Denis, Hanschmann Eva-Maria, Mandelkow Robert, Gelbrich Nadine, Zimmermann Uwe, Walther Reinhard, Ekkernkamp Axel, Sckell Axel, Kramer Axel, Burchardt Martin, Lillig Christopher H., Stope Matthias B., Ahmad Aamir, Cold Atmospheric Plasma Treatment Induces Anti-Proliferative Effects in Prostate Cancer Cells by Redox and Apoptotic Signaling Pathways, PLOS ONE, 10, 7, 2015. Crossref

  10. Chen Chao-Yu, Cheng Yun-Chien, Cheng Yi-Jing, Synergistic effects of plasma-activated medium and chemotherapeutic drugs in cancer treatment, Journal of Physics D: Applied Physics, 51, 13, 2018. Crossref

  11. Bender Claudia, Kramer Axel, Stope Matthias B., Application in Veterinary Medicine, in Comprehensive Clinical Plasma Medicine, 2018. Crossref

  12. Boehm Daniela, Bourke Paula, Safety implications of plasma-induced effects in living cells – a review of in vitro and in vivo findings, Biological Chemistry, 400, 1, 2018. Crossref

  13. LI Xue, ZHOU Renwu, ZHANG Bo, ZHOU Rusen, OSTRIKOV Ken, FANG Zhi, Design and characteristics investigation of a miniature low-temperature plasma spark discharge device, Plasma Science and Technology, 21, 5, 2019. Crossref

  14. Gökçelli Uğur, Ercan Utku Kürşat, İlhan Enver, Argon Asuman, Çukur Elif, Üreyen Orhan, Prevention of Peritoneal Adhesions by Non-Thermal Dielectric Barrier Discharge Plasma Treatment on Mouse Model: A Proof of Concept Study, Journal of Investigative Surgery, 33, 7, 2020. Crossref

  15. Liu Jin-Ren, Wu Yue-Ming, Xu Gui-Min, Gao Ling-Ge, Ma Yan, Shi Xing-Min, Zhang Guan-Jun, Low-temperature plasma induced melanoma apoptosis by triggering a p53/PIGs/caspase-dependent pathwayin vivoandin vitro, Journal of Physics D: Applied Physics, 52, 31, 2019. Crossref

  16. Yan Dayun, Lin Li, Xu Wenjun, Nourmohammadi Niku, Sherman Jonathan H, Keidar Michael, Cold plasma-based control of the activation of pancreatic adenocarcinoma cells, Journal of Physics D: Applied Physics, 52, 44, 2019. Crossref

  17. Dobrynin Danil, Fridman Gregory, Friedman Gary, Fridman Alexander, Cold Microsecond Spark Discharge Plasma Production of Active Species and Their Delivery into Tissue, in Plasma for Bio-Decontamination, Medicine and Food Security, 2012. Crossref

  18. von Woedtke Th., Reuter S., Masur K., Weltmann K.-D., Plasmas for medicine, Physics Reports, 530, 4, 2013. Crossref

  19. Xu Nan, Cui Xinglei, Fang Zhi, Shi Yaowei, Zhou Ruoyu, A Two-Mode Portable Atmospheric Pressure Air Plasma Jet Device for Biomedical Applications, IEEE Transactions on Plasma Science, 46, 4, 2018. Crossref

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