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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Trace Element Zinc in the Composition of Native Chorionic Gonadotropin

Volume 28, Issue 4, 2018, pp. 337-342
DOI: 10.1615/CritRevEukaryotGeneExpr.2017019373
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ABSTRACT

Human chorionic gonadotropin (hCG) is a most important regulator of embryogenesis and spermatogenesis. Equally important for the development of the fetus is the trace element zinc, which is essential for sustainable fetal development. The involvement of hCG and zinc in the first trimester of pregnancy (embryogenesis) led us to question the possibility of their structural cooperation and inclusion in the native molecule chorionic gonadotropin and zinc atoms. At the same time, we found increasing stability of the hormonal structure in the background of hCG interaction with zinc. Thus, the aim of our research was to study the possible zinc presence in the molecule of native hCG. The drug chorionic gonadotropin (1000 IU lyophilisate) was selected as the object of investigation, representing the native hormone that was derived from the urine of pregnant women. For detection of ionized zinc, we used stripping voltammetry and mass spectrometry with inductively coupled plasma at a high resolution (up to 7.10 g/L). The research of nonmineralized samples of chorionic gonadotropin lyophilisate proved its absence in free zinc. Premineralization of the samples made it possible to reveal zinc presence in nine to 17 atoms/molecule of hormone. Detecting bound zinc in the composition of native chorionic gonadotropin confirms its role as an important structural element, capable of producing compound stability and ensuring specific activity during pregnancy. The composition of native chorionic gonadotropin and a major amount of zinc in the bound state, compared to a relatively small amount of free particles, indicates the existence of the sufficiently strong intramolecular bond of hCG and zinc for maintaining active pregnancy. This fact will allow us to design methods for maintaining stable medication during pregnancy on the basis of regulation of trace-element composition in a patient's blood.

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