Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Methylated DNA Sequences in Genomic Imprinting

Volume 10, Issue 3&4, 2000, 18 pages
DOI: 10.1615/CritRevEukarGeneExpr.v10.i3-4.30
Get accessGet access

ABSTRACT

Genomic imprinting is a special form of epigenetic system that determines the parent-of-origin-specific, or monoallelic, expression of a small number of genes, termed "imprinted" genes. Considerable sequence and methylation analysis of imprinted genes has revealed a common theme: Regions of allele-specific methylation inherited from the gametes, or primary differentially methylated regions (DMRs), are associated with CpG islands and repeat elements, and this overall structure suggests functional significance. For at least three imprinted genes the sequence of the primary DMR constitutes an element able to regulate gene activity in cis — a chromatin insulator and a promoter of an antisense transcript. In these cases the unique feature of imprinting appears to be in the ability to switch the regulatory capacity of these elements on or off by the absence or presence of inherited methylation. Increasing evidence therefore suggests that genomic imprinting for at least some genes constitutes the regulation of gene regulatory elements by methylation. An important challenge now is to determine how the differential methyiation of primary DMR sequences is established in the germ line. If methylation is the primary imprint, then the processes establishing it are the primary imprinting mechanisms. Trans-acting factors that are expressed in one sex of germ line and not the other are likely to be involved, and their ability to methylate may be mediated through repeat elements associated with the sequence of primary DMRs.

CITED BY
  1. Lefèvre Christophe, Mann Jeffrey R., RNA expression microarray analysis in mouse prospermatogonia: Identification of candidate epigenetic modifiers, Developmental Dynamics, 237, 4, 2008. Crossref

  2. Rasmussen Theodore P., Corry Gareth N., Epigenetic pre-patterning and dynamics during initial stages of mammalian preimplantation development, Journal of Cellular Physiology, 225, 2, 2010. Crossref

  3. Davey C., Fraser R., Smolle M., Simmen M.W., Allan J., Nucleosome Positioning Signals in the DNA Sequence of the Human and Mouse H19 Imprinting Control Regions, Journal of Molecular Biology, 325, 5, 2003. Crossref

  4. Rodriguez-Jato S., Nicholls R. D., Driscoll D. J., Yang T. P., Characterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus, Nucleic Acids Research, 33, 15, 2005. Crossref

  5. Davey C, Allan J, Nucleosome positioning signals and potential H–DNA within the DNA sequence of the imprinting control region of the mouse Igf2r gene, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1630, 2-3, 2003. Crossref

  6. Yang Pok Kwan, Kuroda Mitzi I., Noncoding RNAs and Intranuclear Positioning in Monoallelic Gene Expression, Cell, 128, 4, 2007. Crossref

  7. Li Tao, Chen Huiling, Li Wei, Cui Jiuwei, Wang Guanjun, Hu Xiang, Hoffman Andrew R., Hu Jifan, Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines, Human Molecular Genetics, 23, 1, 2014. Crossref

  8. Zhang He, Niu Beibei, Hu Ji-Fan, Ge Shengfang, Wang Haibo, Li Tao, Ling Jianqun, Steelman Brandon N., Qian Guanxiang, Hoffman Andrew R., Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II, Journal of Cell Biology, 193, 3, 2011. Crossref

  9. Huang Daixin, Lin Xiaoyan, Chen Hui, Yang Qingen, Jie Ya, Zhai Xiandun, Yin Hui, Parentally imprinted allele (PIA) typing in the differentially methylated region upstream of the human H19 gene, Forensic Science International: Genetics, 2, 4, 2008. Crossref

  10. Lui Julian C., Finkielstain Gabriela P., Barnes Kevin M., Baron Jeffrey, An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 295, 1, 2008. Crossref

  11. Mai Qingyun, Mai Xiuyun, Huang Xin, Zhang Dan, Huang Kejun, Zhou Canquan, Imprinting Status in Two Human Parthenogenetic Embryonic Stem Cell Lines: Analysis of 63 Imprinted Gene Expression Levels in Undifferentiated and Early Differentiated Stages, Stem Cells and Development, 27, 6, 2018. Crossref

  12. Cooney Craig A., Dave Apurva A., Wolff George L., Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring, The Journal of Nutrition, 132, 8, 2002. Crossref

  13. Yang Youwen, Hu Ji-Fan, Ulaner Gary A., Li Tao, Yao Xiaoming, Vu Thanh H., Hoffman Andrew R., Epigenetic regulation ofIgf2/H19 imprinting at CTCF insulator binding sites, Journal of Cellular Biochemistry, 90, 5, 2003. Crossref

  14. Pfeifer Gerd P., Szabó Piroska E., Song Jikui, Protein Interactions at Oxidized 5-Methylcytosine Bases, Journal of Molecular Biology, 432, 6, 2020. Crossref

  15. Pfeifer Gerd P., 5-Methylcytosine and Its Oxidized Derivatives, in Clinical Epigenetics, 2019. Crossref

  16. Pask Andrew, Insights on Imprinting from Beyond Mice and Men, in Genomic Imprinting, 925, 2012. Crossref

  17. Berg Lutz‐Peter, Cooper David N, Genes: Types, in eLS, 2005. Crossref

  18. Stimson Krista M., Vertino Paula M., Methylation-mediated Silencing of TMS1/ASC Is Accompanied by Histone Hypoacetylation and CpG Island-localized Changes in Chromatin Architecture, Journal of Biological Chemistry, 277, 7, 2002. Crossref

  19. Levine Jeoffrey J, Stimson-Crider Krista M, Vertino Paula M, Effects of methylation on expression of TMS1/ASC in human breast cancer cells, Oncogene, 22, 22, 2003. Crossref

  20. Wang Haibo, Ge Shengfang, Qian Guanxiang, Li Wei, Cui Jiuwei, Wang Guanjun, Hoffman Andrew R., Hu Ji-Fan, Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells, Experimental Cell Research, 338, 2, 2015. Crossref

  21. Plass Christoph, Soloway Paul D, DNA methylation, imprinting and cancer, European Journal of Human Genetics, 10, 1, 2002. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain