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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Architectural Genetic and Epigenetic Control of Regulatory Networks: Compartmentalizing Machinery for Transcription and chromatin remodeling in nuclear Microenvironments

Volume 20, Issue 2, 2010, pp. 149-155
DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.50
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ABSTRACT

The regulatory machinery that governs genetic and epigenetic control of gene expression for biological processes and cancer is organized in nuclear microenvironments. Strategic placement of transcription factors at target gene promoters in punctate microenvironments of interphase nuclei supports scaffolding of co- regulatory proteins and the convergence as well as integration of regulatory networks. The organization and localization of regulatory complexes within the nucleus can provide signatures that are linked to regulatory activity. Retention of transcription factors at gene loci in mitotic chromosomes contributes to epigenetic control of cell fate and lineage commitment, as well as to persistence of transformed and tumor phenotypes. Mechanistic understanding of the architectural assembly of regulatory machinery can serve as a basis for treating cancer with high specificity and minimal off-target effects.

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  3. Nair Sujit S., Kumar Rakesh, Chromatin remodeling in Cancer: A Gateway to regulate gene Transcription, Molecular Oncology, 6, 6, 2012. Crossref

  4. Alvarenga Elenice M., Mondin Mateus, Rodrigues Vera L.C.C., Andrade Larissa M., Vidal Benedicto de Campos, Mello Maria Luiza S., Contribution of AT-, GC-, and methylated cytidine-rich DNA to chromatin composition in Malpighian tubule cell nuclei of Panstrongylus megistus (Hemiptera, Reduviidae), Acta Histochemica, 114, 7, 2012. Crossref

  5. Shapiro James A., How life changes itself: The Read–Write (RW) genome, Physics of Life Reviews, 10, 3, 2013. Crossref

  6. Xu Juan, Yu Bo, Hong Christine, Wang Cun-Yu, KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells, International Journal of Oral Science, 5, 4, 2013. Crossref

  7. Bidwell Joseph P., Alvarez Marta B., Hood Mark, Childress Paul, Functional Impairment of Bone Formation in the Pathogenesis of Osteoporosis: The Bone Marrow Regenerative Competence, Current Osteoporosis Reports, 11, 2, 2013. Crossref

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