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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Dual Protective and Cytotoxic Benefits of Mesenchymal Stem Cell Therapy in Combination with Chemotherapy/Radiotherapy for Cancer Patients

Volume 25, Issue 3, 2015, pp. 203-207
DOI: 10.1615/CritRevEukaryotGeneExpr.2015013843
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ABSTRACT

Cancer is a major health problem in the world, and scientists seek innovative treatment strategies with higher efficacy and lower toxicity than the existing therapeutic agents. In this way, stem cell researchers try to reveal new pathways that will eventually benefit patients. Stem cell research has proven that mesenchymal stem cells (MSCs) possess anticancer activities, and their protein-rich secretome showed similar effects. MSCs also secrete cytokines that play an active role in healing and regeneration processes. Because of their known plasticity, MSCs display a variety of characteristics and functions in different environments, depending on their interactions with various cell types and tissues. Therefore, we hypothesize that MSC therapy in combination with anticancer medicines can potentiate cytotoxic effects on cancer cells. In addition, because of their regenerative capacity, MSCs can protect normal tissues from adverse cytotoxic drug reactions. They may also help rescue injured tissues from these toxic damages or systemic pathological events that occur during cancer treatment. MSC therapy may double the beneficial effects on cancer and normal cells. As our knowledge of systems biology and biotechnological methodology is progressing, this idea can move forward as a treatment option.

CITED BY
  1. Saadatpour Z, Bjorklund G, Chirumbolo S, Alimohammadi M, Ehsani H, Ebrahiminejad H, Pourghadamyari H, Baghaei B, Mirzaei H R, Sahebkar A, Mirzaei H, Keshavarzi M, Molecular imaging and cancer gene therapy, Cancer Gene Therapy, 2016. Crossref

  2. Hendijani Fatemeh, Explant culture: An advantageous method for isolation of mesenchymal stem cells from human tissues, Cell Proliferation, 50, 2, 2017. Crossref

  3. Kang Jingjing, Zhang Li, Luo Xiao, Ma Xiangyu, Wang Gaoying, Yang Yanhui, Yan Yongmin, Qian Hui, Zhang Xu, Xu Wenrong, Mao Fei, Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer, BioMed Research International, 2018, 2018. Crossref

  4. Feng Hao, Zhao Jing-kun, Schiergens Tobias S, Wang Pu-xiongzhi, Ou Bao-chi, Al-Sayegh Rami, Li Ming-lun, Lu Ai-guo, Yin Shuai, Thasler Wolfgang E, Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation, British Journal of Cancer, 118, 3, 2018. Crossref

  5. Kalamegam Gauthaman, Sait Khalid Hussein Wali, Ahmed Farid, Kadam Roaa, Pushparaj Peter Natesan, Anfinan Nisreen, Rasool Mahmood, Jamal Mohammad Sarwar, Abu-Elmagd Muhammed, Al-Qahtani Mohammed, Human Wharton's Jelly Stem Cell (hWJSC) Extracts Inhibit Ovarian Cancer Cell Lines OVCAR3 and SKOV3 in vitro by Inducing Cell Cycle Arrest and Apoptosis, Frontiers in Oncology, 8, 2018. Crossref

  6. Bellei Barbara, Migliano Emilia, Tedesco Marinella, Caputo Silvia, Papaccio Federica, Lopez Gianluca, Picardo Mauro, Adipose tissue-derived extracellular fraction characterization: biological and clinical considerations in regenerative medicine, Stem Cell Research & Therapy, 9, 1, 2018. Crossref

  7. Münz Franziska, Lopez Perez Ramon, Trinh Thuy, Sisombath Sonevisay, Weber Klaus-Josef, Wuchter Patrick, Debus Jürgen, Saffrich Rainer, Huber Peter E., Nicolay Nils H., Human mesenchymal stem cells lose their functional properties after paclitaxel treatment, Scientific Reports, 8, 1, 2018. Crossref

  8. Ghorbani Saba, Maleki Masoud, Inhibition of Cervical Cancer Cell Line Hela by Human Wharton’s Jelly Stem Cells Through Induction of Apoptosis, Gene, Cell and Tissue, 7, 1, 2020. Crossref

  9. Ocansey Dickson Kofi Wiredu, Qiu Wei, Wang Jingyan, Yan Yongmin, Qian Hui, Zhang Xu, Xu Wenrong, Mao Fei, The Achievements and Challenges of Mesenchymal Stem Cell-Based Therapy in Inflammatory Bowel Disease and Its Associated Colorectal Cancer, Stem Cells International, 2020, 2020. Crossref

  10. Abbasi Samaneh, Bazyar Reza, Saremi Mohammad Ali, Alishiri Gholamhoseen, Seyyedsani Nasrin, Farhoudi Sefidan Jadid Mahdieh, Khorrami Afshin, Golmarz Parisa Emami, Jahangirzadeh Gholamreza, Bedoustani Ahmad Babazadeh, isazadeh Alireza, Hajazimian Saba, Amoodizaj Fatemeh Firouzi, Wharton jelly stem cells inhibits AGS gastric cancer cells through induction of apoptosis and modification of MAPK and NF-κB signaling pathways, Tissue and Cell, 73, 2021. Crossref

  11. Huang Ruixue, Zhou Ping-Kun, DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy, Signal Transduction and Targeted Therapy, 6, 1, 2021. Crossref

  12. Bouhtit Fatima, Najar Mehdi, Agha Douâa Moussa, Melki Rahma, Najimi Mustapha, Sadki Khalid, Lewalle Philippe, Hamal Abdellah, Lagneaux Laurence, Merimi Makram, The biological response of mesenchymal stromal cells to thymol and carvacrol in comparison to their essential oil: An innovative new study, Food and Chemical Toxicology, 134, 2019. Crossref

  13. Guo Gang, Tan Zhaobang, Liu Yaping, Shi Feiyu, She Junjun, The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer, Stem Cell Research & Therapy, 13, 1, 2022. Crossref

  14. Huang Kevin Chih-Yang, Chiang Shu-Fen, Chang Hsin-Yu, Chen William Tzu-Liang, Yang Pei-Chen, Chen Tsung-Wei, Liang Ji-An, Shiau An‑Cheng, Ke Tao-Wei, Clifford Chao K. S., Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade, Cell Death & Disease, 13, 7, 2022. Crossref

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