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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Events of Molecular Changes in Epithelial-Mesenchymal Transition

Volume 26, Issue 2, 2016, pp. 163-171
DOI: 10.1615/CritRevEukaryotGeneExpr.2016016307
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ABSTRACT

EMT is the process by which epithelial cells, characterized by well-developed intercellular contacts, transdifferentiate into motile and invasive mesenchymal cells. This process is associated with the loss of transmembrane intercellular adhesion molecule E-cadherin and disruption of cell-cell junctions along with acquisition of migratory properties. EMT is integral in embryonic development, wound healing, and stem cell behavior; however, its aberrant activation by micro-environmental alterations and abnormal stimuli can lead to cancer progression. Here, we review the different molecular changes associated with EMT that are responsible for downregulation of epithelial genes. Increased knowledge of the EMT process is essential for therapeutic targeting of cancer cells.

CITED BY
  1. Xu Bing, Zhou Minjie, Qiu Wencai, Ye Jueming, Feng Qiming, CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through AKT pathway, Cancer Medicine, 6, 5, 2017. Crossref

  2. Zheng Tong, Lu Min, Wang Ting, Zhang Chunfeng, Du Xiaojuan, NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865, 12, 2018. Crossref

  3. Zhang Yujiao, Fan Yizeng, Huang Shangke, Wang Guanying, Han Rui, Lei Fuxi, Luo Anqi, Jing Xin, Zhao Lin, Gu Shanzhi, Zhao Xinhan, Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK / mTOR signaling pathway , Cancer Science, 109, 12, 2018. Crossref

  4. Richter Antje M., Küster Miriam M., Woods Michelle L., Walesch Sara K., Gökyildirim Mira Y., Krueger Marcus, Dammann Reinhard H., RASSF10 Is a TGFβ-Target That Regulates ASPP2 and E-Cadherin Expression and Acts as Tumor Suppressor That Is Epigenetically Downregulated in Advanced Cancer, Cancers, 11, 12, 2019. Crossref

  5. Sun Hui, Zhao Anran, Li Min, Dong Hao, Sun Yifei, Zhang Xue, Zhu Qian, Bukhari Ashfaq-Ahmad-Shah, Cao Changchun, Su Dongming, Liu Yun, Liang Xiubin, Interaction of calcium binding protein S100A16 with myosin-9 promotes cytoskeleton reorganization in renal tubulointerstitial fibrosis, Cell Death & Disease, 11, 2, 2020. Crossref

  6. Jin Fanjie , Xiao Di , Zhao Tiansuo , Yu Ming , Proteasome inhibitor MG132 suppresses pancreatic ductal adenocarcinoma‑cell migration by increasing ESE3 expression, Oncology Letters, 2019. Crossref

  7. Yi Zhigang , Pu Yanchuan , Gou Ruoyan , Chen Yonggang , Ren Xiaojun , Liu Wenzhong , Dong Ping , Silencing of RIPK4 inhibits epithelial‑mesenchymal transition by inactivating the Wnt/β‑catenin signaling pathway in osteosarcoma, Molecular Medicine Reports, 2020. Crossref

  8. Xie Pan, Yuan Fu-Qiang, Huang Ma-Sha, Zhang Wei, Zhou Hong-Hao, Li Xi, Liu Zhao-Qian, DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  9. Wang Yaozong, Sun Naikun, Zhang Zheyi, Zhou Yuanyuan, Liu Hongyi, Zhou Xu, Zhang Ying, Zhao Yilin, Overexpression Pattern of miR-301b in Osteosarcoma and Its Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10, Biochemical Genetics, 2022. Crossref

  10. Gowhari Shabgah Arezoo, Al-Obaidi Zaid Mahdi Jaber, Sulaiman Rahman Heshu, Kamal Abdelbasset Walid, Suksatan Wanich, Bokov Dmitry O, Thangavelu Lakshmi, Turki Jalil Abduladheem, Jadidi-Niaragh Farhad, Mohammadi Hamed, Mashayekhi Kazem, Gholizadeh Navashenaq Jamshid, Does CCL19 act as a double-edged sword in cancer development?, Clinical and Experimental Immunology, 207, 2, 2022. Crossref

  11. Patmanidi Alexandra L., Champeris Tsaniras Spyridon, Karamitros Dimitris, Kyrousi Christina, Lygerou Zoi, Taraviras Stavros, Concise Review: Geminin—A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells, Stem Cells, 35, 2, 2017. Crossref

  12. Zhao Tiansuo, Jiang Wenna, Wang Xiuchao, Wang Hongwei, Zheng Chen, Li Yang, Sun Yan, Huang Chongbiao, Han Zhi-bo, Yang Shengyu, Jia Zhiliang, Xie Keping, Ren He, Hao Jihui, ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin, Cancer Research, 77, 4, 2017. Crossref

  13. Bhattacharya Susinjan, Metabolic Reprogramming and Cancer: 2022, Qeios, 2022. Crossref

  14. Bhattacharya Susinjan, Metabolic Reprogramming and Cancer: 2022, Qeios, 2022. Crossref

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