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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Notch Signaling: A Potential Therapeutic Target for Hematologic Malignancies

Volume 26, Issue 3, 2016, pp. 239-246
DOI: 10.1615/CritRevEukaryotGeneExpr.2016016587
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ABSTRACT

Notch signaling is a well-conserved cell-fate determining factor in embryo development, and the dyregulation of this signaling is frequently observed in many types of cancers, including hematological malignancies. In this review, we briefly describe the Notch signaling pathway, and we primarily focus on the relationship between Notch and hematological malignancies. We also discuss the clinical development of promising agents including γ-secretase inhibitors (GSIs) and monoclonal antibodies (mAbs). Complete response has been observed among patients with T-cell acute lymphoblastic leukemia (T-ALL) when treated with GSIs. Furthermore, a recent study has suggested that targeting Zmiz1, a direct, selective cofactor of Notch1, rather than targeting Notch directly, maybe helpful to reduce the current target-related toxicities. Taken together, we summarize the role of Notch signaling in hematological malignancies and discuss the treatment strategies for these diseases through targeting Notch signaling.

CITED BY
  1. Mrazek Frantisek, Schneiderova Petra, Kriegova Eva, Raida Ludek, Kuba Adam, Gajdos Petr, Königova Nikola, Onderkova Jana, Ambruzova Zuzana, Profile of Inflammation-Associated Proteins in Early Post-Transplant Samples of Patients After Allogeneic Hematopoietic Stem Cell Transplantation: a Preliminary Study, Archivum Immunologiae et Therapiae Experimentalis, 64, S1, 2016. Crossref

  2. Evangelisti Camilla, Chiarini Francesca, McCubrey James, Martelli Alberto, Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update, International Journal of Molecular Sciences, 19, 7, 2018. Crossref

  3. Shan Huizhuang, Li Xiangyun, Xiao Xinhua, Dai Yuting, Huang Jinyan, Song Junjun, Liu Meng, Yang Li, Lei Hu, Tong Yin, Zhou Li, Xu Hanzhang, Wu Yingli, USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia, Signal Transduction and Targeted Therapy, 3, 1, 2018. Crossref

  4. Zhu Bo, Sun Lichun, Luo Wei, Li Min, Coy David H., Yu Long, Yu Wenbo, Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2, Oncotarget, 8, 14, 2017. Crossref

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