International Journal of Physiology and Pathophysiology
Published 4 issues per year
ISSN Print: 2155-014X
ISSN Online: 2155-0158
SJR:
0.116
The Effect of Exogenous Melatonin on Bone Remodeling
Volume 7,
Issue 2, 2016,
pp. 149-155
DOI: 10.1615/IntJPhysPathophys.v7.i2.60
ABSTRACT
We studied the effects of pharmacological doses of melatonin (5 mg / kg) introduced in springtime during 28 days on parameters of bone remodeling in 3-month old male rats with high and low levels of energy metabolism. Decreased activity of osteoblasts and increased osteoclast activity, independent from intensity of energy metabolism, have been shown, as well as increased concentration of glycosaminoglycans and free amino acids, testifying to the inhibition of bone tissue physiological remodeling. The latter is not beneficial in maintaining integrity of the bone organic matrix and fixing the inorganic component of the connective tissue, namely hydroxyapatite crystals.
KEY WORDS: melatonin, bone tissue
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