Library Subscription: Guest
International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Hematological Effects of Protein Kinases Inhibitor Maleimide Derivative in Dimethylhydrazine-Induced Colorectal Carcinogenesis in Rats

Volume 6, Issue 3, 2015, pp. 191-201
DOI: 10.1615/IntJPhysPathophys.v6.i3.30
Get accessGet access

ABSTRACT

The effect of the protein kinases inhibitor maleimide derivative (MI-1, 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrole-2, 5-dione) on the blood cells of rats with 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis was studied. It has been revealed that the introduction of MI-1 in a dose of 2.7 mg / kg for 20 weeks prevents anemia which accompanies cancer and complicates the course of the latter. This is evidenced by the reduction in the number of reticulocytes (0.19[0.15; 0.21]·1012/l) and restitution of the content (18.02 [17.44;19.03] pg) and concentration (309.42 [292.38;318.27] g/l) of hemoglobin in the erythrocytes to the control values (0.17 [0.15;0.19], 18.31 [17.95;18.45]), 310.78 [306.25;316.18], respectively) in contrast to the group injected with DMH (0.28 [0.24;0.39]; 17.50 [17.00;17.96]; 288.10 [284.71;303.73], respectively). MI-1 normalizes the count of monocytes (1.40 [0.95; 2.50] ·109 /l) and platelets (646.32 [575.23; 700.50] ·109 /l) in the blood after 26 weeks of experiment. In subjected to DMH rats, these parameters are significantly higher (1.97 [1.52; 2.58], 783.90 [687.64; 922.27], respectively) compared to the control group (1.23 [0.94; 1.68], 629.34 [590.19; 711.48], respectively). MI-1 reduces the involvement of these cells in the tumor progression and metastasis. Reduced monocytosis and thrombocytosis may be mediated by: 1) a decrease in the number of tumors and the area of colon lesions and, consequently, the influence of their cytokines on hematopoietic tissue; 2) an inhibition of proliferation and differentiation of hematopoietic progenitor cells through inhibiting receptor protein kinases of vascular endothelial and epidermal growth factors and non-receptor PDK1-, Src- and Syk-protein kinases that are involved in hematopoiesis and carcinogenesis.

Latest Issue

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain