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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Hepatoprotective Activity and the Mechanisms of Action of Ganoderma lucidum (Curt.:Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) (Aphyllophoromycetideae) (Review)

Volume 5, Issue 2, 2003, 22 pages
DOI: 10.1615/InterJMedicMush.v5.i2.20
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ABSTRACT

Herbal medicines are always considered to be a safe and useful approach for the treatment of chronic hepatopathy. Ganoderma luciudm (Curt.:Fr.) P. Karst. [(Ling Zhi, Reishi mushroom) (Aphyllophoromycetideae)], a highly ranked medicinal mushroom in Oriental traditional medicine, has been widely used for the treatment of chronic hepatopathy of various etiologies. Data from in vitro and animal studies indicate that G. lucidum extracts (mainly polysaccharides or triterpenoids) exhibit protective activities against liver injury induced by toxic chemicals (e.g., CCl4) and Bacillus Calmette-Guerin (BCG) plus lipopolysaccharide (LPS). G. lucidum also showed anti–hepatitis B virus (HBV) activity in a duckling study. Recently, a randomized placebo-controlled clinical study showed that treatment with G. lucidum polysaccharides for 12 weeks reduced hepatitis B e antigen (HBeAg) and HBV DNA in 25% (13/52) patients with HBV infection. The mechanisms of the hepatoprotective effects of G. lucidum have been largely undefined. However, accumulating evidence suggests several possible mechanisms. These include antioxidant and radical-scavenging activity, modulation of hepatic Phase I and II enzymes, inhibition of b-glucuronidase, antifibrotic and antiviral activity, modulation of nitric oxide production, maintenance of hepatocellular calcium homeostasis, and immunomodulating effects. G. lucidum could represent a promising approach for the management of various chronic hepatopathies. Further studies are needed to explore the kinetics and mechanisms of action of G. lucidum constituents with hepatoprotective activities.

CITED BY
  1. HE HUI, HE JU-PING, SUI YU-JIE, ZHOU SHI-QI, WANG JIN, THE HEPATOPROTECTIVE EFFECTS OFGANODERMA LUCIDUMPEPTIDES AGAINST CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN MICE, Journal of Food Biochemistry, 32, 5, 2008. Crossref

  2. Kwon Sang-Chul, Kim Yun-Bae, Antifibrotic activity a fermentation filtrate ofGanoderma lucidum, Laboratory Animal Research, 27, 4, 2011. Crossref

  3. Shi Yanling, Sun Jie, He Hui, Guo Hui, Zhang Sheng, Hepatoprotective effects of Ganoderma lucidum peptides against d-galactosamine-induced liver injury in mice, Journal of Ethnopharmacology, 117, 3, 2008. Crossref

  4. Peng Xing-Rong, Liu Jie-Qing, Han Zhong-Hui, Yuan Xiao-Xi, Luo Huai-Rong, Qiu Ming-Hua, Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells, Food Chemistry, 141, 2, 2013. Crossref

  5. Shevelev Oleg B., Akulov Andrey E., Dotsenko Anna S., Kontsevaya Galina V., Zolotykh Mariya A., Gerlinskaya Lyudmila A., Veprev Sergey G., Goryachkovskaya Tat'yana N., Zhukova Natal'ya A., Kolchanov Nikolay A., Pel'tek Sergey E., Moshkin Mikhail P., Neurometabolic Effect of Altaian FungusGanoderma lucidum(Reishi Mushroom) in Rats Under Moderate Alcohol Consumption, Alcoholism: Clinical and Experimental Research, 39, 7, 2015. Crossref

  6. Zhao Zhen-Zhu, Yin Rong-Hua, Chen He-Ping, Feng Tao, Li Zheng-Hui, Dong Ze-Jun, Cui Bao-Kai, Liu Ji-Kai, Two new triterpenoids from fruiting bodies of fungusGanoderma lucidum, Journal of Asian Natural Products Research, 17, 7, 2015. Crossref

  7. Chatterjee Ananya, Acharya Krishnendu, Include mushroom in daily diet—A strategy for better hepatic health, Food Reviews International, 32, 1, 2016. Crossref

  8. Pham Hong Ngoc, Hoang Le Son, Phung Van Trung, Hsu Tsai-Ching, Hepatoprotective activity of Ganoderma lucidium (Curtis) P. Karst against cyclophosphamide-induced liver injury in mice, Cogent Biology, 2, 1, 2016. Crossref

  9. Soares Andréia, de Sá-Nakanishi Anacharis, Bracht Adelar, da Costa Sandra, Koehnlein Eloá, de Souza Cristina, Peralta Rosane, Hepatoprotective Effects of Mushrooms, Molecules, 18, 7, 2013. Crossref

  10. Zhao Chao, Fan Jinlin, Liu Yuanyuan, Guo Weiling, Cao Hui, Xiao Jianbo, Wang Ying, Liu Bin, Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis, Food Chemistry, 271, 2019. Crossref

  11. 邱 婕宁, Hepatoprotective Effects of Ganoderma lucidum on Carbon Tetrachloride-Induced Chronic Liver Disease in Rats, Hans Journal of Food and Nutrition Science, 07, 02, 2018. Crossref

  12. Ramesh Sindhu, Majrashi Mohammed, Almaghrabi Mohammed, Govindarajulu Manoj, Fahoury Eddie, Fadan Maali, Buabeid Manal, Deruiter Jack, Clark Randall, Mulabagal Vanisree, Agrawal Dinesh Chandra, Moore Timothy, Dhanasekaran Muralikrishnan, Overview of Therapeutic Efficacy of Mushrooms, in Medicinal Mushrooms, 2019. Crossref

  13. Viet Hung Tran, Thang Phan Nguyen Truong, Hien Ha Minh, Diep Vu Thi, Thu Nguyen Thi, Tan Duong Minh, Pham Duy Toan, Thi Ha Do, Huynh Duyen Thi My, Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries, Plants, 11, 23, 2022. Crossref

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