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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immunopotentiating Properties of Lentinan (1®3)-b-D-glucan Extracted from Culinary–Medicinal Shiitake Mushroom Lentinus edodes (Berk.) Singer (Agaric

Volume 5, Issue 4, 2003, 20 pages
DOI: 10.1615/InterJMedicMush.v5.i4.20
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ABSTRACT

The immunopotentiating efficacy of lentinan, a fully purified (1®3)-b-D-glucan extracted from culinary–medicinal mushroom Lentinus edodes (Berk.) Singer was investigated both in vitro and in vivo. The oral administration of lentinan to AKR mice exerted strong antitumor activity, resulting in raised levels of lymphocytokines such as IFN-g, TNF-a, IL-2, and IL-1a. Tissue cultures of murine macrophages CRL-2019, B-lymphocytes HB-284, and T-lymphocytes CRL-8179, which were treated with lentinan, showed high levels of activation using flow cytometry. Activated immunocytes, particularly the T-helper cells by lentinan, might render the physiological constitutions of the host highly cancer and infection resistant. Adoptive immunotherapy of the immunodeficient mice such as the nude (athymic) mice, B-cell deficient mice, and SCID (severe combined immunodeficient) mice via the transfer of the lentinan-activated immunocytes resulted in the inhibition of tumor growth. Lentinan appeared to represent a unique class of host defense potentiators (HDP), protecting the hosts from the side effects of conventional therapeutic measures and improving various kinds of immunological parameters with no toxic side-effects in animal models.

CITED BY
  1. Kim Jong-Soo, Choi Dubok, Jung Bock-Gie, Lee Bong-Joo, Lim Geum-Sook, Lee Myung Koo, Cha Wol-Suk, Cho Hoon, Effects of fruiting body extracts of Lentinus edodes cultivated using corn cob on biological activities, Korean Journal of Chemical Engineering, 30, 4, 2013. Crossref

  2. Ulbricht Catherine, An Evidence-Based Systematic Review of Beta-Glucan by the Natural Standard Research Collaboration, Journal of Dietary Supplements, 11, 4, 2014. Crossref

  3. Moradali Mohammad-Fata, Mostafavi Hossein, Ghods Shirin, Hedjaroude Ghorban-Ali, Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi), International Immunopharmacology, 7, 6, 2007. Crossref

  4. Rastall R.A., Diez-Municio M., Forssten S.D., Hamaker B., Meynier A., Moreno F. Javier, Respondek F., Stah B., Venema K., Wiese M., Structure and function of non-digestible carbohydrates in the gut microbiome, Beneficial Microbes, 13, 2, 2022. Crossref

  5. You Hong, Abraham Evelyn J., Mulligan Jason, Zhou Yucheng, Montoya Maureen, Willig Jennifer, Chen Bo-Kai, Wang Chin-Kun, Wang Li-Shu, Dong Athena, Shamtsyan Mark, Nguyen Haiuyen, Wong Andrea, Wallace Taylor C., Label compliance for ingredient verification: regulations, approaches, and trends for testing botanical products marketed for “immune health” in the United States, Critical Reviews in Food Science and Nutrition, 2022. Crossref

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