Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
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Anti-inflammatory and Free Radical Scavenging Activities of Polysaccharide−Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae)
ABSTRACT
Phellinus rimosus (Berk.) Pilát is a polypore mushroom found growing on jackfruit trees (Atrocarpus heterophyllus) in Kerala, India. Our previous investigations have demonstrated a variety of biological activities of this species. In this article, we report the anti-inflammatory and free radical scavenging activities of a polysaccharide−protein complex (PPC-Pr) isolated from the fruiting bodies of Ph. rimosus. The PPC-Pr was isolated from the hot water extract by solvent precipitation, depro-teinization, dialysis, and freeze drying. The anti-inflammatory activity of PPC-Pr was determined by carrageenan- and dextran-induced acute and formalin-induced chronic inflammatory models. The free radical scavenging activity of PPC-Pr was determined by evaluating superoxide radical, hydroxyl radical, nitric oxide, and 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical scavenging activities; inhibition of lipid peroxidation; and ferric reducing antioxidant power (FRAP). The PPC-Pr showed 75.24% and 88.28% inhibition of acute and 65.74% inhibition of chronic inflammation when treated at a concentration of 50 mg/kg body weight. PPC-Pr also showed significant hydroxyl radical scavenging activity (IC50: 430.0 ± 5.0) and lipid peroxidation-inhibiting activity (IC50: 253.3 ± 7.6). The results thus reveal that PPC-Pr possesses profound anti-inflammatory and free radical scavenging activities. The findings suggest the potential therapeutic use of the polysaccharide−protein complex (PPC-Pr) isolated from Ph. rimosus.
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