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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Apoptotic Effect of Extract from Medicinal Mushroom from Taiwan Taiwanofungus salmoneus (Higher Basidiomycetes) Mycelium Combined with or without Cisplatin on Hepatocellular Carcinoma Cells

Volume 17, Issue 6, 2015, pp. 567-577
DOI: 10.1615/IntJMedMushrooms.v17.i6.70
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ABSTRACT

Hepatocellular carcinoma is a cancer of high mortality; therefore, the effective therapy on this cancer is an imperative issue. Recently, anticancer agent combined with natural products has been demonstrated to increase apoptosis of various cancer cells effectively. Accordingly, we investigated the apoptotic effect and possible mechanism of the ethanol extract from Taiwanofungus salmoneus (=Antrodia salmonea) mycelium (TsE) alone or in combination with cisplatin in SK-Hep-1 cells. In this study, the proliferation of SK-Hep-1 cells could be inhibited at various concentrations of TsE for 24 h whereas TsE combined with cisplatin would inhibit the cell proliferation more notably. Moreover, the DNA damage and the interruption of cell cycle of SK-Hep-1 cells would be effectively raised after incubation with TsE combined with cisplatin for 24 h. The apoptosis of cells was dramatically induced, and the expression of caspases 3, 8, and 9, apoptosis-related protein, were significantly upregulated. Therefore, we proposed that the TsE combined with cisplatin inhibited cell proliferation by elevating sub-G1 phase, inducing DNA damage, activating caspases 3, 8, and 9 activities, and triggering cells apoptosis. These results reveal that TsE could be a potential adjuvant chemotherapeutic agent.

CITED BY
  1. Chang Chia-Ting, Hseu You-Cheng, Thiyagarajan Varadharajan, Huang Hui-Chi, Hsu Li-Sung, Huang Pei-Jane, Liu Jer-Yuh, Liao Jiunn-Wang, Yang Hsin-Ling, Antrodia salmonea induces G2 cell-cycle arrest in human triple-negative breast cancer (MDA-MB-231) cells and suppresses tumor growth in athymic nude mice, Journal of Ethnopharmacology, 196, 2017. Crossref

  2. Karuppaiya Palaniyandi, Akbar Abdul Khader, Mycotherapy of Antrodia salmonea: A Taiwanese Medicinal Mushroom, in Medicinal Mushrooms, 2019. Crossref

  3. Lin Chun-Ping, Wu Yao-Chien, Lin Zhi-Wei, Tsai Shu-Yao, Assessment of the thermal and oxidative stability of Antrodia salmonea extract in dripping pills via DSC and TAM air analyses, Journal of Thermal Analysis and Calorimetry, 144, 2, 2021. Crossref

  4. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

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