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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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In Vitro and In Vivo Antitumoral Activity of Exobiopolymers from the Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes)

Volume 19, Issue 9, 2017, pp. 767-775
DOI: 10.1615/IntJMedMushrooms.2017024492
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ABSTRACT

We studied antitumor activity in vitro and in vivo and partial chemical characterization of exobiopolymers (EBPs) of Agaricus brasiliensis produced by submerged cultivation. The EBPs comprised 61.2% total sugar and 22.3% total protein, and the chromatographic profile mainly identified mannose (65.5%), galactose (17.5%), and glucose (13.1%). In vitro analysis revealed a dose with antitumor effectiveness, time-dependent treatment, and 46% inhibition of solid Walker 256 tumors in rats. Metabolic changes were significant in the spleens of the animals; this is possibly related to higher immune activity triggered by the presence of EBPs in the treated group. The increase of nitric oxide production by peritoneal macrophages from animals may be related to the tumor reduction observed, because nitric oxide acts as an important effector pathway in the defense of the organism.

CITED BY
  1. Hetland Geir, Tangen Jon-Magnus, Mahmood Faiza, Mirlashari Mohammad Reza, Nissen-Meyer Lise Sofie Haug, Nentwich Ivo, Therkelsen Stig Palm, Tjønnfjord Geir Erland, Johnson Egil, Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies, Nutrients, 12, 5, 2020. Crossref

  2. Liang Jingjing, Zhang Meina, Wang Xingnan, Ren Yichen, Yue Tianli, Wang Zhouli, Gao Zhenpeng, Edible fungal polysaccharides, the gut microbiota, and host health, Carbohydrate Polymers, 273, 2021. Crossref

  3. Câmara Neto João Francisco, Campelo Matheus da Silva, Cerqueira Gilberto Santos, de Miranda João Antônio Leal, Guedes Jhonyson Arruda Carvalho, de Almeida Raimundo Rafael, Soares Sandra de Aguiar, Gramosa Nilce Viana, Zocolo Guilherme Julião, Vieira Ícaro Gusmão Pinto, Ricardo Nágila Maria Pontes Silva, Ribeiro Maria Elenir Nobre Pinho, Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice, Journal of Ethnopharmacology, 292, 2022. Crossref

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