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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Antioxidant-Rich Peptide Fractions Derived from High-Altitude Chinese Caterpillar Medicinal Mushroom Ophiocordyceps sinensis (Ascomycetes) Inhibit Bacterial Pathogens

Volume 21, Issue 2, 2019, pp. 155-168
DOI: 10.1615/IntJMedMushrooms.2019030013
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ABSTRACT

Ophiocordyceps sinensis (=Cordyceps sinensis), a medicinal mushroom native to the Orient, has been extensively used for the past few centuries in traditional Chinese medicine because of its immunomodulatory, antiinflammatory, and nutraceutical properties. In the present study, three antioxidant and antibacterial Ophiocordyceps peptide fractions (COPs) were separated from the Indian variety of O. sinensis on a Sephadex G-25 resin. Amide bonds in the COPs were confirmed by Fourier transform infrared spectroscopy and nuclear magnetic resonance. Cationic and hydrophobic amino acids, which are reported to be the major constituent amino acids of antimicrobial peptides, were identified in the COPs by matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography. Putative secondary structures were predicted by circular dichroism to be β-sheets and random coils. The COPs demonstrated substantial antioxidant potential by scavenging 2,2-diphenyl-l-picryl-hydrazyl-hydrate (median inhibitory concentration [IC50] values, 4.79-18.7 mg/mL) and 2,2'-azino-bis-3-ethylbenzothiazoline-6-sul-phonic acid (IC50 values, 4.51-14.05 mg/mL) free radicals and also by chelating heavy metal ions. Additionally, the peptide fractions were capable of significantly inhibiting bacterial pathogens viz. Escherichia coli and Salmonella typhi. The potential antibacterial mechanisms of action were established to be generation of reactive oxygen species and intracellular protein leakage within the bacterial cells.

CITED BY
  1. Rakhee , Mishra Jigni, Yadav Renu Bala, Meena D. K., Arora Rajesh, Sharma R. K., Misra Kshipra, Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies, 3 Biotech, 11, 1, 2021. Crossref

  2. Zhou Juanjuan, Chen Mengfei, Wu Shujian, Liao Xiyu, Wang Juan, Wu Qingping, Zhuang Mingzhu, Ding Yu, A review on mushroom-derived bioactive peptides: Preparation and biological activities, Food Research International, 134, 2020. Crossref

  3. Arrigoni Roberto, Ballini Andrea, Topi Skender, Bottalico Lucrezia, Jirillo Emilio, Santacroce Luigi, Antibiotic Resistance to Mycobacterium tuberculosis and Potential Use of Natural and Biological Products as Alternative Anti-Mycobacterial Agents, Antibiotics, 11, 10, 2022. Crossref

  4. Xia Yidan, Wang Dongxu, Li Jiaqi, Chen Minqi, Wang Duo, Jiang Ziping, Liu Bin, Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation, Frontiers in Pharmacology, 13, 2022. Crossref

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