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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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The Extraction and Development of Antitumor-Active Polysaccharides from Medicinal Mushrooms in Japan (Review)

Volume 1, Issue 1, 1999, pp. 9-29
DOI: 10.1615/IntJMedMushrooms.v1.i1.20
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ABSTRACT

It has been known for many years that most mushrooms with known effects against cancer belong to the family Polyporaceae s.l. (Agaricales s.l.). However, the components responsible for such action have not been clearly defined. In Japan, in 1968, a hot water extract from some edible mushrooms belonging to the family Polyporaceae s.l., showed a marked host-mediated antitumor activity. Since then, numerous researchers have isolated active polysaccharides and have identified them to be (1→3)-β-D-glucopyranans with a (1→6)-β-D-glucosyl branch containing protein. Several antitumor polysaccharides, some hetero-β-glucans and their protein complexes, such as xyloglucans and acidic β-glucan containing uronic acid, are insoluble in water. They were, however, isolated from the extracts using large amounts of dilute alkali with Japanese (8 species) and Chinese (5 species) mushrooms. Several trials have been made to enhance activity by chemical modification, such as polyalcohols formed by a mild Smith degradation and the products formed by BH4-reduction after 104-oxidation. Mushroom polysaccharides are considered to be biological response modifiers (BRM), or immunopotentiators, because of their action mechanism. In Japan, three different polysaccharide antitumor agents have been developed from the fruit body, mycelium, and cultured medium, of three mushroom species.

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