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Critical Reviews™ in Physical and Rehabilitation Medicine

Published 4 issues per year

ISSN Print: 0896-2960

ISSN Online: 2162-6553

SJR: 0.141 SNIP: 0.129 CiteScore™:: 0.6 H-Index: 18

Indexed in

Insulin Resistance and Tendinopathy

Volume 27, Issue 1, 2015, pp. 35-41
DOI: 10.1615/CritRevPhysRehabilMed.2015014074
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ABSTRACT

Tendinopathy is most prevalent among males suffering from insulin resistance secondary to metabolic syndrome and type II diabetes mellitus. The mechanistic relationship between insulin resistance and the development of tendinopathy is not fully understood. Tendon tissue changes associated with insulin resistance include disruption of collagen cross-linking, alterations in proteoglycan synthesis, and the presence of advanced glycosylation end products. In this review we focus on the epidemiology of tendinopathy among insulin resistant populations and the potential mechanisms underlying tendon degeneration related to insulin resistance and related diseases.

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