Critical Reviews™ in Physical and Rehabilitation Medicine
Published 4 issues per year
ISSN Print: 0896-2960
ISSN Online: 2162-6553
SJR:
0.141
SNIP:
0.129
CiteScore™::
0.6
H-Index:
18
Indexed in
Insulin Resistance and Tendinopathy
Volume 27,
Issue 1, 2015,
pp. 35-41
DOI: 10.1615/CritRevPhysRehabilMed.2015014074
ABSTRACT
Tendinopathy is most prevalent among males suffering from insulin resistance secondary to metabolic syndrome and type II diabetes mellitus. The mechanistic relationship between insulin resistance and the development of tendinopathy is not fully understood. Tendon tissue changes associated with insulin resistance include disruption of collagen cross-linking, alterations in proteoglycan synthesis, and the presence of advanced glycosylation end products. In this review we focus on the epidemiology of tendinopathy among insulin resistant populations and the potential mechanisms underlying tendon degeneration related to insulin resistance and related diseases.
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