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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Short-Term Effects of Titanium Dioxide Nanofiber on the Renal Function of Male Sprague Dawley Rats

Volumen 37, Edición 2, 2018, pp. 127-138
DOI: 10.1615/JEnvironPatholToxicolOncol.2018025351
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SINOPSIS

Titanium dioxide nanofiber (TDNF) is widely used in the manufacture of various household products, including cosmetics. As a result, the possibility exists for TDNFs to affect human health. Because the kidneys are responsible for filtering out waste from the blood, the goal of the present study was to investigate the short-term effects of TDNF on kidney function of male Sprague Dawley rats. To achieve study objectives, 6- to 7-wk-old male rats were exposed via oral gavage to a total of 0, 40, and 60 parts per million of TDNF for 2 wk. The TDNF was fabricated by electrospinning and then dissolved in water. We measured serum concentration of lactate dehydrogenase, renal histopathology, identification of TDNF in kidney tissue via scanning electron microscopy, and quantitative amounts of titanium-47 in kidney tissue. We also measured specific gene-expression analysis of transcripts involved in apoptosis, inflammation, cell-division regulation, cell structure, and motility. Results showed a slight dose-dependent reduction in renal weight. In contrast, a concentration-dependent elevation in titanium-47 amounts was noted in kidney tissue. We found no significant differences in histopathological patterns. Gnat3 and Hepacam3 were up-regulated in TDNF-treated groups. Up-regulation of NF-κB likely indicated the involvement of renal-tissue inflammation via an independent mechanism. Similarly, Gadd45-α was significantly overexpressed in kidney tissues. This transcript was previously increased following stressful growth-arrest conditions and treatment with DNA-damaging agents. Our overall results suggest marginal renal toxicity in Sprague Dawley rats after ingesting TDNF.

CITADO POR
  1. Déciga-Alcaraz Alejandro, Medina-Reyes Estefany I., Delgado-Buenrostro Norma L., Rodríguez-Ibarra Carolina, Ganem-Rondero Adriana, Vázquez-Zapién Gustavo J., Mata-Miranda Mónica M., Limón-Pacheco Jorge H., García-Cuéllar Claudia M., Sánchez-Pérez Yesennia, Chirino Yolanda I., Toxicity of engineered nanomaterials with different physicochemical properties and the role of protein corona on cellular uptake and intrinsic ROS production, Toxicology, 442, 2020. Crossref

  2. Said Ahmed Abdou, Nasr Yasmin, Galal Azza A. A., Abdelhamid Ahmed E., Mohamed Haiam A., Metwally Mohamed M. M., Said Mahmoud A., Nassan Mohamed A., Dahran Naief, Mohamed Amany Abdel-Rahman, Concerns with Male Infertility Induced by Exposure to Titanium Nanoparticles and the Supporting Impact of Pelargonium graveolens Essential Oil: Morphometric Records in Male-Wistar Rats, Life, 12, 5, 2022. Crossref

  3. Bianchi Massimiliano G., Campagnolo Luisa, Allegri Manfredi, Ortelli Simona, Blosi Magda, Chiu Martina, Taurino Giuseppe, Lacconi Valentina, Pietroiusti Antonio, Costa Anna L., Poland Craig A., Baird Daniel, Duffin Rodger, Bussolati Ovidio, Bergamaschi Enrico, Length-dependent toxicity of TiO2 nanofibers: mitigation via shortening, Nanotoxicology, 14, 4, 2020. Crossref

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