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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Determination of Apoptotic Effect of Juglone on Human Bladder Cancer TCC-SUP and RT-4 Cells: An In Vitro Study

Volumen 37, Edición 2, 2018, pp. 173-181
DOI: 10.1615/JEnvironPatholToxicolOncol.2018025226
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SINOPSIS

This study aimed to investigate the effects of juglone on the human bladder carcinoma cell lines TCC-SUB and RT-4 in monolayer and spheroid cultures. Cells were treated with juglone at 24, 48, and 72 h of incubation. The activity of caspase-3 was detected in vitro using a caspase-3 colorimetric assay kit according to the manufacturer's instructions. The bromodeoxyuridine (BrdU) labeling index was used to determine the cells of the synthesis phase. The terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay was used to determine the death of cells in both the monolayer and spheroid cultures. The control group had a large S-phase fraction and many of the TCC-SUB and RT-4 cells nuclei were observed to be positive for BrdU. The dead cell count was higher in the TCC-SUB and RT-4 cell lines with juglone applied than in the controls. We conclude that juglone significantly inhibits the proliferation and induces the apoptosis of TCC-SUB and RT-4 cells in vitro.

CITADO POR
  1. Ahmad Taseer, Suzuki Yuichiro J., Juglone in Oxidative Stress and Cell Signaling, Antioxidants, 8, 4, 2019. Crossref

  2. Özgöçmen Meltem, Bayram Dilek, Yavuz Türel Gülçin, Toğay Vehbi Atahan, Şahin Calapoğlu Nilüfer, Secoisolariciresinol diglucoside induces caspase‐3‐mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells, Journal of Food Biochemistry, 45, 5, 2021. Crossref

  3. Xia Yong, Chen Ruijiao, Lu Guangzhen, Li Changlin, Lian Sen, Kang Taek-Won, Jung Young Do, Natural Phytochemicals in Bladder Cancer Prevention and Therapy, Frontiers in Oncology, 11, 2021. Crossref

  4. Özgöçmen Meltem, Bayram Dilek, Armağan İlkay, Türel Gülçin Yavuz, Sevimli Murat, Şenol Nurgül, Is Quercetin Beneficial for Colon Cancer? A Cell Culture Study, Using the Apoptosis Pathways, Anti-Cancer Agents in Medicinal Chemistry, 22, 1, 2022. Crossref

  5. Tang Yu Ting, Li Yang, Chu Peng, Ma Xiao Dong, Tang Ze Yao, Sun Zhao Lin, Molecular biological mechanism of action in cancer therapies: Juglone and its derivatives, the future of development, Biomedicine & Pharmacotherapy, 148, 2022. Crossref

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