Suscripción a Biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Mangiferin Inhibits Inflammation and Cell Proliferation, and Activates Proapoptotic Events via NF-κB Inhibition in DMBA-Induced Mammary Carcinogenesis in Rats

Volumen 40, Edición 2, 2021, pp. 1-9
DOI: 10.1615/JEnvironPatholToxicolOncol.2021036057
Get accessGet access

SINOPSIS

The purpose of this study was to investigate the anti-inflammatory, antiproliferatiive, and proapoptotic molecular mechanisms of mangiferin (MGN) against mammary carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA). Mammary cancer in rats was induced by single-dose subcutaneous injection of 0.5 ml DMBA (80 mg/kg in sesame oil) in the mammary gland. Increased tumor incidence and volume and other tumorigenic properties were observed. Further, we observed in these rats reduced antioxidant enzyme activity and elevated thiobarbituric acid reactive substance (TBARS) levels in plasma and tissues. DMBA-induced rats shows enhanced expression of the inflammatory markers NF-κBp65, COX-2, and iNOS and proliferation of PCNA and Cyclin D1, and overexpression of the antiapoptotic marker Bcl-2. Mangiferin (100 mg/kg body weight), administered orally once per day, significantly enhanced (p < 0.05) antioxidant levels and reduced TBARS levels. Moreover, MGN inhibited NF-κBp65 nucleus transcriptional activation, thereby suppressing inflammation and cell proliferation, and it increased proapoptotic proteins. Apoptosis was confirmed by TUNEL assay. In summary, MGN suppressed DMBA-induced mammary carcinogenesis through enhanced antioxidant levels, NF-κB inhibition, and positive regulation of apoptotic signals.

REFERENCIAS
  1. Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biol Res. 2017;50:33.

  2. Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, Alsharif U, Alvis-Guzman N, Amini E, Anderson BO, Aremu O. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: A systematic analysis for the global burden of disease study. JAMA Oncol. 2018;4(11):1553-68.

  3. Mansfield CM. A review of the etiology of breast cancer. J Nat Med Assoc. 1993;85:217.

  4. Karimi B, Ashrafi M, Shomali T, Yektaseresht A. Therapeutic effect of simvastatin on DMBA-induced breast cancer in mice. Fund Clin Pharmacol. 2019;33(1):84-93.

  5. Takeda T, Tsubaki M, Sakamoto K, Ichimura E, Enomoto A, Suzuki Y, Itoh T, Imano M, Tanabe G, Muraoka O, Matsuda H. Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model. Toxicol Appl Pharmacol. 2016;306:105-12.

  6. Chen H, Sun B, Wang S, Pan S, Gao Y, Bai X, Xue D. Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: Involvement of cell cycle arrest and inactivation of nuclear factor-KB. J Cancer Res Clin. 2010;136(6):897-903.

  7. Ahn KS, Aggarwal BB. Transcription factor NF-KB: A sensor for smoke and stress signals. Ann NY Acad Sci. 2005;1056(1):218-33.

  8. Yoshimia N, Matsunaga K, Katayama M, Yamada Y, Kuno T, Qiao Z, Hara A, Yamahara J, Mori H. The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Lett. 2001;163:163-70.

  9. Du S, Liu H, Lei T, Xie X, Wang H, He X, Tong R, Wang Y. Mangiferin: An effective therapeutic agent against several disorders. Mol Med Rep. 2018;18(6):4775-86.

  10. Leiro JM, Alvarez E, Arranz JA, Siso IG, Orallo F. In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-a and transforming growth factor-P genes. Biochem Pharmacol. 2003;65(8):1361-71.

  11. Cuccioloni M, Bonfili L, Mozzicafreddo M, Cecarini V, Scuri S, Cocchioni M, Nabissi M, Santoni G, Eleuteri AM, Angeletti M. Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition. Food Fund 2016;7(10):4299-309.

  12. Rajakumar T, Pugalendhi P, Thilagavathi S. Dose response chemopreventive potential of allyl isothiocyanate against 7, 12-dimethylbenz (a) anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. Chem Biol Interact. 2015;231:35-43.

  13. Rajendran P, Ekambaram G, Sakthisekaran D. Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biol Pharm Bull. 2008;31(6):1053-8.

  14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54.

  15. Legrand-Poels S, Schoonbrodt S, Piette J. Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochem J. 2000;349:765-73.

  16. Kathiresan S, Govindhan A. [6]-Shogaol, a novel chemopreventor in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Phytother Res. 2016;30(4):646-53.

  17. Annamalai G, Suresh K. [6]-Shogaol attenuates inflammation, cell proliferation via modulating NF-KB and AP-1 oncogenic signaling in 7,12-dimethylbenz [a] anthracene induced oral carcinogenesis. Biomed Pharmacother. 20181;98:484-90.

  18. Wang Z, Zhang X. Chemopreventive activity of honokiol against 7,12-dimethylbenz[a]anthracene-induced mammary cancer in female Sprague Dawley rats. Front Pharmacol. 2017;8:320.

  19. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ. Comparative study of human and rat mammary tumorigenesis. Lab Invest. 1990;62:244-78.

  20. Bishayee A, Mandal A, Thoppil RJ, Darvesh AS, Bhatia D. Chemopreventive effect of a novel oleanane triter-penoid in a chemically induced rodent model of breast cancer. Int J Cancer. 2013;133(5):1054-63.

  21. Costa I, Solanas M, Escrich E. Histopathologic characterization of mammary neoplastic lesions induced with 7,12 dimethylbenz(alpha)anthracene in the rat: A comparative analysis with human breast tumors. Arch Pathol Lab Med. 2002;126:915-27.

  22. Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016;2016:3164734.

  23. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state. Nutr J. 2016;15(1):71.

  24. Anbuselvam C, Vijayavel K, Balasubramanian MP. Protective effect of Operculina turpethum against 7,12-dimethylbenz(a)anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chem Biol Interact. 2007;168(3):229-36.

  25. Singh R, Kumar N, Saminathan M, Singh KP, Dhama K, Milton A, Kurade NP. Therapeutic effect of hydroethanolic extract of Trianthema portulacastrum L. against N-nitroso-N-methylurea-induced mammary tumors in Wistar rats. IJTK. 2020;19(2):406-15.

CITADO POR
  1. Zhang Meng, Hu Guanhua, Shao Nan, Qin Yunpeng, Chen Qian, Wang Yan, Zhou Peng, Cai Biao, Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols, Inflammopharmacology, 29, 5, 2021. Crossref

  2. Li Baoying, Wang Yu, Zhao Hongjing, Yin Kai, Liu Yachen, Wang Dongxu, Zong Hui, Xing Mingwei, Oxidative stress is involved in the activation of NF-κB signal pathway and immune inflammatory response in grass carp gill induced by cypermethrin and/or sulfamethoxazole, Environmental Science and Pollution Research, 29, 13, 2022. Crossref

  3. Spampinato Mariarita, Carota Giuseppe, Sferrazzo Giuseppe, Fuochi Virginia, Distefano Alfio, Ronsisvalle Simone, Sipala Federica, Giuffrida Rosario, Furneri Pio Maria, Di Rosa Michelino, Tibullo Daniele, Li Volti Giovanni, Barbagallo Ignazio, Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells, Pharmaceutics, 14, 12, 2022. Crossref

1600 Vistas de artículos 50 Descargas de artículos Métrica
1600 PUNTOS DE VISTA 50 DESCARGAS 3 Crossref CITAS Google
Scholar
CITAS

Artículos con contenido similar:

Chemopreventive Efficacy of (+)-Catechin-Rich Aqueous Extract of Acacia catechu Willd. Heartwood against 7,12-Dimethylbenz[a]Anthracene-Induced Hepatocarcinoma in Balb/c Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Manu Sharma, Jitender Monga, Chetan Singh Chauhan
Neferine Inhibits 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis by Suppression of Cell Proliferation and Induction of Apoptosis via Modulation of the PI3K/AKT/NF-κB Signaling Pathway Journal of Environmental Pathology, Toxicology and Oncology, Vol.40, 2021, issue 3
Xiaoying Lin, Ying Xiong, Zhongli Sun, Huaikun Ni, Linhan Yang
Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 1
Zhanzhan Xiao, Elamaran Ananda Jothi, Huazhi Zhang, Ping Lv, Jiangfei Yang
Nuclear Factor Kappa B: A Pro-Inflammatory, Transcription Factor−Mediated Signalling Pathway in Lung Carcinogenesis and Its Inhibition By Nonsteroidal Anti-Inflammatory Drugs Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Sankar Nath Sanyal, Shruti Setia
Chemoprevention of Colon Cancer through Inhibition of Angiogenesis and Induction of Apoptosis by Nonsteroidal Anti-Inflammatory Drugs Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 3
Sankar Nath Sanyal, Preety Ghanghas, Chandan Rana, Shelly Jain
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain