Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Aniline Derivative-Induced Methemoglobin in Rats
SINOPSIS
Methemoglobinemia and hemolysis are the most prominent side-effects of exposure to a wide variety of arylamine drugs, including agricultural and industrial chemicals. Recent studies with aniline and dapsone have identified N-hydroxyl metabolites as the red blood cell (RBC) mediators. This study examines the time-course methemoglobinemic potential of several halogenated aniline phenylhydroxylamines. Symptoms of aniline poisoning include headache, fatigue, dizziness, respiratory and cardiac arrest, and possibly death. Initial studies indicated that the parent compounds are converted to their toxic metabolites (N-hydroxylamine), which enter the RBC and react with oxyhemoglobin. Consequent reduction of molecular oxygen to active oxygen species occurs, leading to RBC damage. Our laboratory is investigating the role of redox cycling and an alternative hypothesisthat a "hydroxylamine-centered" radical formed during arylhydroxylamine-oxyhemoglobin reaction results in RBC injury. The methemoglobinemic capacities of several structurally related N-hydroxy derivatives of anilinephenylhydroxylamine (PHA), p-fluoro-, p-chloro-, p-bromo-, and p-iodo-PHAwere studied spectrophotometri-cally by treating washed rat RBC at concentrations ranging from 30 to 300 μM of the test compounds for up to 240 minutes. The results showed dose- and time-dependent changes in the induction of methemoglobin (MetHb) by aniline derivatives. The MetHb levels peaked to as high as 75% and remained elevated up to 240 minutes, depending on the electronegativity of halogenated phenylhydroxylamine aniline. This study supports the previous findings that there may be several aniline-derived metabolites other than PHA that are capable of inducing MetHb. The minimum dose required to induce this effect and duration of the MetHb may vary with the test agent.
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NEUHAEUSER CHRISTOPH, WEIGAND NIKOLA, SCHAAF HEIDRUM, MANN VALESCO, CHRISTOPHIS PETROS, HOWALDT HANS PETER, HECKMANN MATTHIAS, Postoperative methemoglobinemia following infiltrative lidocaine administration for combined anesthesia in pediatric craniofacial surgery, Pediatric Anesthesia, 2007. Crossref
-
Umbreit Jay, Methemoglobin—It's not just blue: A concise review, American Journal of Hematology, 82, 2, 2007. Crossref
-
Bergamaschi Mateus M., Alcantara Greyce Kelly Steinhorst, Valério Daniel Augusto Rodrigues, Queiroz Regina Helena Costa, Curcumin could prevent methemoglobinemia induced by dapsone in rats, Food and Chemical Toxicology, 49, 7, 2011. Crossref
-
Weingarten Toby N., Gleich Stephen J., Craig James R., Sprung Juraj, Methemoglobinemia in the Setting of Chronic Transdermal Lidocaine Patch Use, Pain Medicine, 13, 7, 2012. Crossref
-
Anilin [MAK Value Documentation in German language, 2007], in The MAK-Collection for Occupational Health and Safety, 2012. Crossref
-
Aniline [MAK Value Documentation, 2010b], in The MAK-Collection for Occupational Health and Safety, 2012. Crossref
-
Pizon Anthony F., Schwartz Anna R., Shum Leo M., Rittenberger Jon C., Lower Darla R., Giannoutsos Spiros, Virji Mohamed A., Krasowski Matthew D., Toxicology laboratory analysis and human exposure top-chloroaniline, Clinical Toxicology, 47, 2, 2009. Crossref
-
Liu Haining, Walker Larry A., Nanayakkara N. P. Dhammika, Doerksen Robert J., Methemoglobinemia Caused by 8-Aminoquinoline Drugs: DFT Calculations Suggest an Analogy to H4B’s Role in Nitric Oxide Synthase, Journal of the American Chemical Society, 133, 5, 2011. Crossref
-
Jin Shuo, Zhang Tong, Fu Xinyu, Duan Zhongliang, Sun Jianwen, Wang Yue, Aniline exposure activates receptor-interacting serine/threonineprotein kinase 1 and causes necroptosis of AML12 cells, Toxicology and Industrial Health, 38, 8, 2022. Crossref