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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Aniline Derivative-Induced Methemoglobin in Rats

Volumen 24, Edición 1, 2005, pp. 57-66
DOI: 10.1615/JEnvPathToxOncol.v24.i1.60
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SINOPSIS

Methemoglobinemia and hemolysis are the most prominent side-effects of exposure to a wide variety of arylamine drugs, including agricultural and industrial chemicals. Recent studies with aniline and dapsone have identified N-hydroxyl metabolites as the red blood cell (RBC) mediators. This study examines the time-course methemoglobinemic potential of several halogenated aniline phenylhydroxylamines. Symptoms of aniline poisoning include headache, fatigue, dizziness, respiratory and cardiac arrest, and possibly death. Initial studies indicated that the parent compounds are converted to their toxic metabolites (N-hydroxylamine), which enter the RBC and react with oxyhemoglobin. Consequent reduction of molecular oxygen to active oxygen species occurs, leading to RBC damage. Our laboratory is investigating the role of redox cycling and an alternative hypothesis—that a "hydroxylamine-centered" radical formed during arylhydroxylamine-oxyhemoglobin reaction results in RBC injury. The methemoglobinemic capacities of several structurally related N-hydroxy derivatives of aniline—phenylhydroxylamine (PHA), p-fluoro-, p-chloro-, p-bromo-, and p-iodo-PHA—were studied spectrophotometri-cally by treating washed rat RBC at concentrations ranging from 30 to 300 μM of the test compounds for up to 240 minutes. The results showed dose- and time-dependent changes in the induction of methemoglobin (MetHb) by aniline derivatives. The MetHb levels peaked to as high as 75% and remained elevated up to 240 minutes, depending on the electronegativity of halogenated phenylhydroxylamine aniline. This study supports the previous findings that there may be several aniline-derived metabolites other than PHA that are capable of inducing MetHb. The minimum dose required to induce this effect and duration of the MetHb may vary with the test agent.

CITADO POR
  1. NEUHAEUSER CHRISTOPH, WEIGAND NIKOLA, SCHAAF HEIDRUM, MANN VALESCO, CHRISTOPHIS PETROS, HOWALDT HANS PETER, HECKMANN MATTHIAS, Postoperative methemoglobinemia following infiltrative lidocaine administration for combined anesthesia in pediatric craniofacial surgery, Pediatric Anesthesia, 2007. Crossref

  2. Umbreit Jay, Methemoglobin—It's not just blue: A concise review, American Journal of Hematology, 82, 2, 2007. Crossref

  3. Bergamaschi Mateus M., Alcantara Greyce Kelly Steinhorst, Valério Daniel Augusto Rodrigues, Queiroz Regina Helena Costa, Curcumin could prevent methemoglobinemia induced by dapsone in rats, Food and Chemical Toxicology, 49, 7, 2011. Crossref

  4. Weingarten Toby N., Gleich Stephen J., Craig James R., Sprung Juraj, Methemoglobinemia in the Setting of Chronic Transdermal Lidocaine Patch Use, Pain Medicine, 13, 7, 2012. Crossref

  5. Anilin [MAK Value Documentation in German language, 2007], in The MAK-Collection for Occupational Health and Safety, 2012. Crossref

  6. Aniline [MAK Value Documentation, 2010b], in The MAK-Collection for Occupational Health and Safety, 2012. Crossref

  7. Pizon Anthony F., Schwartz Anna R., Shum Leo M., Rittenberger Jon C., Lower Darla R., Giannoutsos Spiros, Virji Mohamed A., Krasowski Matthew D., Toxicology laboratory analysis and human exposure top-chloroaniline, Clinical Toxicology, 47, 2, 2009. Crossref

  8. Liu Haining, Walker Larry A., Nanayakkara N. P. Dhammika, Doerksen Robert J., Methemoglobinemia Caused by 8-Aminoquinoline Drugs: DFT Calculations Suggest an Analogy to H4B’s Role in Nitric Oxide Synthase, Journal of the American Chemical Society, 133, 5, 2011. Crossref

  9. Jin Shuo, Zhang Tong, Fu Xinyu, Duan Zhongliang, Sun Jianwen, Wang Yue, Aniline exposure activates receptor-interacting serine/threonineprotein kinase 1 and causes necroptosis of AML12 cells, Toxicology and Industrial Health, 38, 8, 2022. Crossref

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