Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Regulation of Regulatory T Cells: Role of Dendritic Cells and Toll-Like Receptors
SINOPSIS
Regulatory T cells (Treg) are characterized by high-level surface CD25 and intracellular FoxP3 expression. Treg are instrumental in the maintenance of peripheral immune tolerance and the control of adaptive immune responses. Naturally occuring Treg suppress T-cell responses by cell contact-dependent mechanisms, whereas induced regulatory cells, including Tr1 cells, secrete inhibitory cytokines such as transforming growth factor (TGF)-β and interleukin-10. The interplay between Treg and antigen-responsive T cells is modulated by dendritic cells (DC). Whereas immature myeloid precursors of DC suppress T-cell activation per se and immature DC support Treg development, mature DC can override Treg-mediated suppression in vitro and in vivo. Mature DC activated through Toll-like receptor (TLR) pattern recognition receptors produce proinflammatory cytokines, including interleukin-6, which render responder T cells refractory to the suppressive effect of Treg. In addition, Treg also express certain TLR, and the activation and/or suppressor function of Treg is modulated directly by the respective ligands. In this review, we discuss current models of how signals delivered through innate immune receptors in response to pathogen-associated molecular patterns affect adaptive immune responses via modulation of Treg function.
-
Garaci Enrico, Pica Francesca, Serafino Annalucia, Balestrieri Emanuela, Matteucci Claudia, Moroni Gabriella, Sorrentino Roberta, Zonfrillo Manuela, Pierimarchi Pasquale, Sinibaldi-Vallebona Paola, Thymosin α1 and cancer: action on immune effector and tumor target cells, Annals of the New York Academy of Sciences, 1269, 1, 2012. Crossref
-
Vitetta L., Briskey D., Hayes E., Shing C., Peake J., A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics, Inflammopharmacology, 20, 5, 2012. Crossref
-
Schmidt Esben Gjerlff Wedebye, Claesson Mogens Helweg, Jensen Simon Skjde, Ravn Peter, Kristensen Nanna Ny, Antigen-presenting cells exposed to Lactobacillus acidophilus NCFM, Bifidobacterium bifidum BI-98, and BI-504 reduce regulatory T cell activity, Inflammatory Bowel Diseases, 16, 3, 2010. Crossref
-
Weersma Rinse K., Crusius Bart J. A., Roberts Rebecca L., Koeleman Bobby P.C., Palomino-Morales Rogelio, Wolfkamp Simone, Hollis-Moffatt Jade E., Festen Eleonora A.M., Meisneris Sander, Heijmans Roel, Noble Colin L., Gearry Richard B., Barclay Murrary L., Gómez-Garcia María, Lopez-Nevot Miguel A., Nieto Antonio, Rodrigo Luis, Radstake Timothy R.D.J., van Bodegraven Adriaan A., Wijmenga Cisca, Merriman Tony R., Stokkers Pieter C.F., Peña Salvador A., Martín Javier, Alizadeh Behrooz Z., Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations†, Inflammatory Bowel Diseases, 16, 12, 2010. Crossref
-
Schwarz Agatha, Navid Fatemeh, Sparwasser Tim, Clausen Björn E., Schwarz Thomas, In vivo reprogramming of UV radiation–induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity, Journal of Allergy and Clinical Immunology, 128, 4, 2011. Crossref
-
Lamprecht Peter, Gross Wolfgang L., Kabelitz Dieter, T cell alterations and lymphoid neogenesis favoring autoimmunity in Wegener's granulomatosis, Arthritis & Rheumatism, 56, 6, 2007. Crossref
-
Qian Bi-Feng, Tonkonogy Susan L., Sartor Balfour R., Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells, Inflammatory Bowel Diseases, 14, 10, 2008. Crossref
-
Jansen Kirstin, Blimkie Darren, Furlong Jeff, Hajjar Adeline, Rein-Weston Annie, Crabtree Juliet, Reikie Brian, Wilson Christopher, Kollmann Tobias, Polychromatic flow cytometric high-throughput assay to analyze the innate immune response to Toll-like receptor stimulation, Journal of Immunological Methods, 336, 2, 2008. Crossref
-
Escors David, Liechtenstein Therese, Perez-Janices Noemi, Schwarze Julia, Dufait Ines, Goyvaerts Cleo, Lanna Alessio, Arce Frederick, Blanco-Luquin Idoia, Kochan Grazyna, Guerrero-Setas David, Breckpot Karine, Assessing T-cell responses in anticancer immunotherapy, OncoImmunology, 2, 10, 2013. Crossref
-
Schwarz Agatha, Noordegraaf Madelon, Maeda Akira, Torii Kan, Clausen Björn E., Schwarz Thomas, Langerhans Cells Are Required for UVR-Induced Immunosuppression, Journal of Investigative Dermatology, 130, 5, 2010. Crossref
-
Shack L. A., Buza J. J., Burgess S. C., The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells, Cancer Immunology, Immunotherapy, 57, 8, 2008. Crossref
-
Hobohm Uwe, Toward general prophylactic cancer vaccination, BioEssays, 31, 10, 2009. Crossref
-
Chang Wen-Chun, Li Chao-Hsu, Huang Su-Cheng, Chang Daw-Yuan, Chou Li-Yun, Sheu Bor-Ching, Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma, Cancer, 116, 24, 2010. Crossref
-
Sonawane Samsher B., Kim James I., Lee Major K., Lee Seoung-Hoon, Duff Patrick E., Moore Daniel J., Lian Moh-Moh, Deng Shaoping, Choi Yongwon, Yeh Heidi, Caton Andrew J., Markmann James F., GITR Blockade Facilitates Treg Mediated Allograft Survival, Transplantation, 88, 10, 2009. Crossref
-
Schwarz Agatha, Schwarz Thomas, UVR-Induced Regulatory T Cells Switch Antigen-Presenting Cells from a Stimulatory to a Regulatory Phenotype, Journal of Investigative Dermatology, 130, 7, 2010. Crossref
-
Escors David, Tumour Immunogenicity, Antigen Presentation, and Immunological Barriers in Cancer Immunotherapy, New Journal of Science, 2014, 2014. Crossref
-
Ilan Yaron, Zigmond Ehud, Lalazar Gadi, Dembinsky Adi, Ben Ya’acov Ami, Hemed Nila, Kasis Ibrahim, Axelrod Elizabeth, Zolotarov Lidya, Klein Athalia, El Haj Madi, Gandhi Roopali, Baecher-Allan Claire, Wu Henry, Murugaiyan Gopal, Kivisakk Pia, Farez Mauricio F., Quintana Francisco J., Khoury Samia J., Weiner Howard L., Oral Administration of OKT3 Monoclonal Antibody to Human Subjects Induces a Dose-Dependent Immunologic Effect in T Cells and Dendritic Cells, Journal of Clinical Immunology, 30, 1, 2010. Crossref
-
Kondo Yasuteru, Ueno Yoshiyuki, Shimosegawa Tooru, Toll-Like Receptors Signaling Contributes to Immunopathogenesis of HBV Infection, Gastroenterology Research and Practice, 2011, 2011. Crossref
-
WATERS B., LILLICRAP D., The molecular mechanisms of immunomodulation and tolerance induction to factor VIII, Journal of Thrombosis and Haemostasis, 7, 9, 2009. Crossref
-
Berk Lieke C.J. van den, Jansen Bastiaan J.H., Siebers-Vermeulen Kim G.C., Netea Mihai G., Latuhihin Talia, Bergevoet Saskia, Raymakers Reinier A., Kögler Gesine, Figdor Carl C., Adema Gosse J., Torensma Ruurd, Toll-like receptor triggering in cord blood mesenchymal stem cells, Journal of Cellular and Molecular Medicine, 13, 9b, 2010. Crossref
-
Vulink Annelie, Radford Kristen J., Melief Cornelis, Hart Derek N.J., , 99, 2008. Crossref
-
QADURA M., OTHMAN M., WATERS B., CHEGENI R., WALKER K., LABELLE A., OZELO M., HOUGH C., LILLICRAP D., Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells, Journal of Thrombosis and Haemostasis, 6, 12, 2008. Crossref
-
Szabo Gyongyi, Mandrekar Pranoti, A Recent Perspective on Alcohol, Immunity, and Host Defense, Alcoholism: Clinical and Experimental Research, 33, 2, 2009. Crossref
-
Iversen Per O., Semaeva Elvira, Sorensen Dag R., Wiig Helge, Sioud Mouldy, Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells, Translational Oncology, 2, 4, 2009. Crossref
-
Escors David, Lopes Luciene, Lin Rongtuan, Hiscott John, Akira Shizuo, Davis Roger J., Collins Mary K., Targeting dendritic cell signaling to regulate the response to immunization, Blood, 111, 6, 2008. Crossref
-
Fairweather DeLisa, Frisancho-Kiss Sylvia, Rose Noel R., Sex Differences in Autoimmune Disease from a Pathological Perspective, The American Journal of Pathology, 173, 3, 2008. Crossref
-
Tietze Julia K., Sckisel Gail D., Hsiao Hui-Hua, Murphy William J., Antigen-specific versus Antigen-nonspecific Immunotherapeutic Approaches for Human Melanoma: The Need for Integration for Optimal Efficacy?, International Reviews of Immunology, 30, 5-6, 2011. Crossref
-
Tian Lei, Altin John A., Makaroff Lydia E., Franckaert Dean, Cook Matthew C., Goodnow Christopher C., Dooley James, Liston Adrian, Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis, Blood, 118, 7, 2011. Crossref
-
Draghiciu Oana, Nijman Hans W., Daemen Toos, From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors, Clinical and Developmental Immunology, 2011, 2011. Crossref
-
Montero Vega M.T., de Andrés Martín A., The significance of toll-like receptors in human diseases, Allergologia et Immunopathologia, 37, 5, 2009. Crossref
-
Lee Na-Ri, Song Eun-Kee, Jang Kyu Yun, Choi Ha Na, Moon Woo Sung, Kwon Keunsang, Lee Ju-Hyung, Yim Chang-Yeol, Kwak Jae-Yong, Prognostic impact of tumor infiltrating FOXP3 positive regulatory T cells in diffuse large B-cell lymphoma at diagnosis, Leukemia & Lymphoma, 49, 2, 2008. Crossref
-
Wesch Daniela, Peters Christian, Oberg Hans-Heinrich, Pietschmann Kathrin, Kabelitz Dieter, Modulation of γδ T cell responses by TLR ligands, Cellular and Molecular Life Sciences, 68, 14, 2011. Crossref
-
Hedayat Mona, Takeda Kiyoshi, Rezaei Nima, Prophylactic and therapeutic implications of toll-like receptor ligands, Medicinal Research Reviews, 32, 2, 2012. Crossref
-
Oberg Hans-Heinrich, Juricke Matthias, Kabelitz Dieter, Wesch Daniela, Regulation of T cell activation by TLR ligands, European Journal of Cell Biology, 90, 6-7, 2011. Crossref
-
Jang Ji-Hyun, Shin Hee Woong, Lee Jung Min, Lee Hyeon-Woo, Kim Eun-Cheol, Park Sang Hyuk, An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp, Mediators of Inflammation, 2015, 2015. Crossref
-
Ezzelarab M. B., Zhang H., Guo H., Lu L., Zahorchak A. F., Wiseman R. W., Nalesnik M. A., Bhama J. K., Cooper D. K. C., Thomson A. W., Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients, American Journal of Transplantation, 16, 7, 2016. Crossref
-
Teixeira Marcia C. A., Pacheco Flavia T. F., Souza Joelma N., Silva Mônica L. S., Inês Elizabete J., Soares Neci M., Strongyloides stercoralisInfection in Alcoholic Patients, BioMed Research International, 2016, 2016. Crossref
-
Lia Ginaldi, Paola Mengoli Lucia, Maddalena Sirufo Maria, Massimo De Martinis, Osteoporosis, Inflammation, and Aging, in Handbook of Immunosenescence, 2018. Crossref
-
Spinner Daryl S., Kascsak Regina B., LaFauci Giuseppe, Meeker Harry C., Ye Xuemin, Flory Michael J., Kim Jae Il, Schuller-Levis Georgia B., Levis William R., Wisniewski Thomas, Carp Richard I., Kascsak Richard J., CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPScin mice immunized with 139A scrapie-associated fibrils, Journal of Leukocyte Biology, 81, 6, 2007. Crossref
-
Bernardo David, Chaparro María, Gisbert Javier P., Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases, Molecular Nutrition & Food Research, 62, 7, 2018. Crossref
-
Oberg Hans-Heinrich, Ly Thi Thuy Hoa, Ussat Sandra, Meyer Tim, Kabelitz Dieter, Wesch Daniela, Differential but Direct Abolishment of Human Regulatory T Cell Suppressive Capacity by Various TLR2 Ligands, The Journal of Immunology, 184, 9, 2010. Crossref
-
Okano Shinji, Yonemitsu Yoshikazu, Shirabe Ken, Kakeji Yoshihiro, Maehara Yoshihiko, Harada Mamoru, Yoshikai Yasunobu, Inoue Makoto, Hasegawa Mamoru, Sueishi Katsuo, Provision of Continuous Maturation Signaling to Dendritic Cells by RIG-I–Stimulating Cytosolic RNA Synthesis of Sendai Virus, The Journal of Immunology, 186, 3, 2011. Crossref
-
Ginaldi Lia, Mengoli Lucia Paola, Sirufo Maria Maddalena, De Martinis Massimo, Osteoporosis, Inflammation, and Aging, in Handbook of Immunosenescence, 2019. Crossref
-
Long S. Alice, Buckner Jane H., CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game, The Journal of Immunology, 187, 5, 2011. Crossref
-
Bleck Bertram, Tse Doris B., Gordon Terry, Ahsan Mohammad R., Reibman Joan, Diesel Exhaust Particle-Treated Human Bronchial Epithelial Cells Upregulate Jagged-1 and OX40 Ligand in Myeloid Dendritic Cells via Thymic Stromal Lymphopoietin, The Journal of Immunology, 185, 11, 2010. Crossref
-
Kobayashi Haruka, Yu Yue, Volk David E., Thymosins, in Hormonal Signaling in Biology and Medicine, 2020. Crossref
-
Cardoso Angelo A., Harnessing the Power of Immunity to Battle Cancer: Much Ado about Nothing or All's Well That Ends Well?, in Principles of Molecular Oncology, 2008. Crossref
-
Anz David, Koelzer Viktor H., Moder Stefan, Thaler Raffael, Schwerd Tobias, Lahl Katharina, Sparwasser Tim, Besch Robert, Poeck Hendrik, Hornung Veit, Hartmann Gunther, Rothenfusser Simon, Bourquin Carole, Endres Stefan, Immunostimulatory RNA Blocks Suppression by Regulatory T Cells, The Journal of Immunology, 184, 2, 2010. Crossref
-
Li Hang, Lu Tong, Sun Wei, Ma Renqiang, Zhong Hua, Wei Yi, Chen Dehua, Wen Yihui, Carlsten Chris, Wen Weiping, Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis, Frontiers in Immunology, 10, 2019. Crossref
-
ROMANI L., BISTONI F., MONTAGNOLI C., GAZIANO R., BOZZA S., BONIFAZI P., ZELANTE T., MORETTI S., RASI G., GARACI E., PUCCETTI P., Thymosin 1: An Endogenous Regulator of Inflammation, Immunity, and Tolerance, Annals of the New York Academy of Sciences, 1112, 1, 2007. Crossref
-
Iversen Per Ole, Sioud Mouldy, Engineering Therapeutic Cancer Vaccines That Activate Antitumor Immunity, in RNA Interference, 1218, 2015. Crossref
-
Sagar Stephen M., Wong Raimond K., Increasing Therapeutic Gain and Controlling Radiation-Induced Injuries with Asian Botanicals and Acupuncture, in Supportive Cancer Care with Chinese Medicine, 2010. Crossref
-
Strainic Michael G., Liu Jinbo, An Fengqi, Bailey Erin, Esposito Andrew, Hamann Jörg, Heeger Peter S., Medof M. Edward, CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity, The American Journal of Pathology, 189, 7, 2019. Crossref
-
Saxena Vijay, Ondr Jennifer K., Magnusen Albert F., Munn David H., Katz Jonathan D., The Countervailing Actions of Myeloid and Plasmacytoid Dendritic Cells Control Autoimmune Diabetes in the Nonobese Diabetic Mouse, The Journal of Immunology, 179, 8, 2007. Crossref
-
Ginaldi Lia, Mengoli Lucia P., De Martinis Massimo, Osteoporosis, Inflammation and Ageing, in Handbook on Immunosenescence, 2009. Crossref
-
Ginaldi Lia, Mengoli Lucia Paola, Sirufo Maria Maddalena, De Martinis Massimo, Osteoporosis, Inflammation, and Aging, in Handbook of Immunosenescence, 2019. Crossref
-
López-Larrea Carlos, Ortega Francisco, Advances in Translational Transplant Immunology, Transplantation, 88, 3S, 2009. Crossref
-
Koelzer Viktor H., Anz David, A Modular Approach to Suppression Assays: TLR Ligands, Conditioned Medium, and Viral Infection, in Innate DNA and RNA Recognition, 1169, 2014. Crossref
-
Fernandez Marian A., Puttur Franz K., Wang Yuan M., Howden Wade, Alexander Stephen I., Jones Cheryl A., T Regulatory Cells Contribute to the Attenuated Primary CD8+and CD4+T Cell Responses to Herpes Simplex Virus Type 2 in Neonatal Mice, The Journal of Immunology, 180, 3, 2008. Crossref
-
Liu Yi, Zhang Yong, Zhang Meng, Meng Jialin, Ma Qingqing, Hao Zongyao, Zheng Meijuan, Zhang Li, Chen Xianguo, Liang Chaozhao, Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis, The Prostate, 81, 1, 2021. Crossref
-
Huang Xiaolun, Moore Daniel J., Ketchum Robert J., Nunemaker Craig S., Kovatchev Boris, McCall Anthony L., Brayman Kenneth L., Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation, Endocrine Reviews, 29, 5, 2008. Crossref
-
van Riet Elly, Everts Bart, Retra Kim, Phylipsen Marion, van Hellemond Jaap J, Tielens Aloysius GM, van der Kleij Desiree, Hartgers Franca C, Yazdanbakhsh Maria, Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization, BMC Immunology, 10, 1, 2009. Crossref
-
Kumar Shyamesh, Buza Joram J., Burgess Shane C., Genotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity, Cancer Microenvironment, 2, 1, 2009. Crossref
-
Tang Kuo-Tung, Chen Hsin-Hua, Chen Tzu-Ting, Bracci Nicole R., Lin Chi-Chien, Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review, Life, 11, 8, 2021. Crossref
-
Maio Michele, Mackiewicz Andrzej, Testori Alessandro, Trefzer Uwe, Ferraresi Virginia, Jassem Jacek, Garbe Claus, Lesimple Thierry, Guillot Bernard, Gascon Pere, Gilde Katalin, Camerini Roberto, Cognetti Francesco, Large Randomized Study of Thymosin α 1, Interferon Alfa, or Both in Combination With Dacarbazine in Patients With Metastatic Melanoma, Journal of Clinical Oncology, 28, 10, 2010. Crossref
-
De Vleeschouwer Steven, Fieuws Steffen, Rutkowski Stefan, Van Calenbergh Frank, Van Loon Johannes, Goffin Jan, Sciot Raf, Wilms Guido, Demaerel Philippe, Warmuth-Metz Monika, Soerensen Niels, Wolff Johannes E.A., Wagner Sabine, Kaempgen Eckhart, Van Gool Stefaan W., Postoperative Adjuvant Dendritic Cell–Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme, Clinical Cancer Research, 14, 10, 2008. Crossref
-
Kim Cheorl-Ho, Innate Immunity Via Glycan-Binding Lectin Receptors, in Glycobiology of Innate Immunology, 2022. Crossref
-
Shu S-A, Lian Z-X, Chuang Y-H, Yang G-X, Moritoki Y, Comstock S S, Zhong R-Q, Ansari A A, Liu Y-J, Gershwin M E, The role of CD11c+ hepatic dendritic cells in the induction of innate immune responses, Clinical and Experimental Immunology, 149, 2, 2007. Crossref
-
Iseghohi Frances, Yahemba Aondona Priscilla, Rowaiye Adekunle Babajide, Oli Angus Nnamdi, Dendritic cells as vaccine targets, in Vaccinology and Methods in Vaccine Research, 2022. Crossref
-
Sun Donglei, Li Chenyang, Chen Shuang, Zhang Xiaolan, Koon Hon W., Emerging Role of Dendritic Cell Intervention in the Treatment of Inflammatory Bowel Disease, BioMed Research International, 2022, 2022. Crossref