Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
iNKT-Cell Responses to Glycolipids
SINOPSIS
Invariant natural killer T (iNKT) cells are an unusual group of T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related protein CD1d. Because iNKT cells play a regulatory role in the immune system, they are attractive targets for immunotherapy. The marine-sponge-derived glycolipid α-galactosylceramide (α-GalCer) potently activates iNKT cells. In vivo administration of α-GalCer to mice or humans results in rapid and robust cytokine secretion by iNKT cells, followed by the activation of a variety of cell types of the innate and adaptive immune systems. These potent immunomodulatory activities of α-GalCer are being exploited for therapeutic purposes. Preclinical studies in mice have demonstrated that α-GalCer and related glycolipids can protect mice against a variety of diseases, including cancer, infections, and several autoimmune and inflammatory conditions. Although α-GalCer treatment of mice is associated with unwanted side-effects, it has been proven safe in clinical trials with cancer patients. These studies have raised significant enthusiasm for the development of effective and safe iNKT-cell-based immunotherapies for a variety of human diseases.
-
Schneider David F., Glenn Cavin H., Faunce Douglas E., Innate Lymphocyte Subsets and Their Immunoregulatory Roles in Burn Injury and Sepsis, Journal of Burn Care & Research, 28, 3, 2007. Crossref
-
Song Liping, Ara Tasnim, Wu Hong-Wei, Woo Chan-Wook, Reynolds C. Patrick, Seeger Robert C., DeClerck Yves A., Thiele Carol J., Sposto Richard, Metelitsa Leonid S., Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma, Journal of Clinical Investigation, 117, 9, 2007. Crossref
-
Xia Chengfeng, Zhang Wenpeng, Zhang Yalong, Chen Wenlan, Nadas Janos, Severin Ryan, Woodward Robert, Wang Bin, Wang Xin, Kronenberg Mitchell, Wang Peng G., The Roles of 3′ and 4′ Hydroxy Groups in α-Galactosylceramide Stimulation of Invariant Natural Killer T Cells, ChemMedChem, 4, 11, 2009. Crossref
-
Zaini Jamal, Andarini Sita, Tahara Minoru, Saijo Yasuo, Ishii Naoto, Kawakami Kazuyoshi, Taniguchi Masaru, Sugamura Kazuo, Nukiwa Toshihiro, Kikuchi Toshiaki, OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice, Journal of Clinical Investigation, 117, 11, 2007. Crossref
-
Wu L., Gabriel C. L., Parekh V. V., Van Kaer L., Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities, Tissue Antigens, 73, 6, 2009. Crossref
-
Miellot-Gafsou Aurore, Biton Jérôme, Bourgeois Elvire, Herbelin André, Boissier Marie-Christophe, Bessis Natacha, Early activation of invariant natural killer T cells in a rheumatoid arthritis model and application to disease treatment, Immunology, 130, 2, 2010. Crossref
-
Yang Feng-Ling, Hua Kuo-Feng, Yang Yu-Liang, Zou Wei, Chen Yen-Po, Liang Shu-Mei, Hsu Hsien-Yeh, Wu Shih-Hsiung, TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria, Glycoconjugate Journal, 25, 5, 2008. Crossref
-
Zhang Wenpeng, Zheng Xincheng, Xia Chengfeng, Perali Ramu Sridhar, Yao Qingjia, Liu Yang, Zheng Pan, Wang Peng George, α-Lactosylceramide as a Novel “Sugar-Capped” CD1d Ligand for Natural Killer T Cells: Biased Cytokine Profile and Therapeutic Activities, ChemBioChem, 9, 9, 2008. Crossref
-
Scott-Browne James P, Matsuda Jennifer L, Mallevaey Thierry, White Janice, Borg Natalie A, McCluskey James, Rossjohn Jamie, Kappler John, Marrack Philippa, Gapin Laurent, Germline-encoded recognition of diverse glycolipids by natural killer T cells, Nature Immunology, 8, 10, 2007. Crossref
-
Exley Mark A., Lynch Lydia, Varghese Bindu, Nowak Michael, Alatrakchi Nadia, Balk Steven P., Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: Reversing tumor-induced defects, Clinical Immunology, 140, 2, 2011. Crossref
-
Van Kaer Luc, Role of invariant natural killer T cells in immune regulation and as potential therapeutic targets in autoimmune disease, Expert Review of Clinical Immunology, 2, 5, 2006. Crossref
-
Major Amy S., Joyce Sebastian, Van Kaer Luc, Lipid metabolism, atherogenesis and CD1-restricted antigen presentation, Trends in Molecular Medicine, 12, 6, 2006. Crossref
-
Renneson Joelle, Guabiraba Rodrigo, Maillet Isabelle, Marques Rafael E., Ivanov Stoyan, Fontaine Josette, Paget Christophe, Quesniaux Valérie, Faveeuw Christelle, Ryffel Bernhard, Teixeira Mauro M., Trottein François, A Detrimental Role for Invariant Natural Killer T Cells in the Pathogenesis of Experimental Dengue Virus Infection, The American Journal of Pathology, 179, 4, 2011. Crossref
-
Brubaker Aleah L, Schneider David F, Kovacs Elizabeth J, Neutrophils and natural killer T cells as negative regulators of wound healing, Expert Review of Dermatology, 6, 1, 2011. Crossref
-
Exley Mark A., Nakayama Toshinori, NKT-cell-based immunotherapies in clinical trials, Clinical Immunology, 140, 2, 2011. Crossref
-
Nowak Michael, Stein-Streilein Joan, Invariant NKT Cells and Tolerance, International Reviews of Immunology, 26, 1-2, 2007. Crossref
-
Parekh Vrajesh V., Lalani Saif, Kaer Luc Van, TheIn VivoResponse of Invariant Natural Killer T Cells to Glycolipid Antigens, International Reviews of Immunology, 26, 1-2, 2007. Crossref
-
Lin Wan-Chen, Blanchette Craig D., Longo Marjorie L., Fluid-Phase Chain Unsaturation Controlling Domain Microstructure and Phase in Ternary Lipid Bilayers Containing GalCer and Cholesterol, Biophysical Journal, 92, 8, 2007. Crossref
-
Pei Bo, Vela Jose Luis, Zajonc Dirk, Kronenberg Mitchell, Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells, Annals of the New York Academy of Sciences, 1253, 1, 2012. Crossref
-
Wingender Gerhard, Kronenberg Mitchell, The Role of Invariant Natural Killer T Cells in Autoimmune Diseases, in The Autoimmune Diseases, 2014. Crossref
-
Roozbeh Maryam, Mohammadpour Hemn, Azizi Gholamreza, Ghobadzadeh Samira, Mirshafiey Abbas, The potential role of iNKT cells in experimental allergic encephalitis and multiple sclerosis, Immunopharmacology and Immunotoxicology, 36, 2, 2014. Crossref
-
Nowak Michael, Schmidt-Wolf Ingo G.H., Natural Killer T Cells Subsets in Cancer, Functional Defects in Prostate Cancer and Implications for Immunotherapy, Cancers, 3, 3, 2011. Crossref
-
Zheng Wenjing, Kollmeyer Jessica, Symolon Holly, Momin Amin, Munter Elizabeth, Wang Elaine, Kelly Samuel, Allegood Jeremy C., Liu Ying, Peng Qiong, Ramaraju Harsha, Sullards M. Cameron, Cabot Myles, Merrill Alfred H., Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1758, 12, 2006. Crossref
-
Gottschalk Catherine, Mettke Elisabeth, Kurts Christian, The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8+ T Cell Generation, Frontiers in Immunology, 6, 2015. Crossref
-
Nowak Michael, Arredouani Mohammed S., Tun-Kyi Adrian, Schmidt-Wolf Ingo, Sanda Martin G., Balk Steven P., Exley Mark A., Unutmaz Derya, Defective NKT Cell Activation by CD1d+ TRAMP Prostate Tumor Cells Is Corrected by Interleukin-12 with alpha-Galactosylceramide, PLoS ONE, 5, 6, 2010. Crossref
-
Kaneko-Tarui Tomoko, Zhang Ling, Austin Kathleen J., Henkes Luiz E., Johnson Joshua, Hansen Thomas R., Pru James K., Maternal and Embryonic Control of Uterine Sphingolipid-Metabolizing Enzymes During Murine Embryo Implantation1, Biology of Reproduction, 77, 4, 2007. Crossref
-
Stanley Amanda C., Zhou Yonghong, Amante Fiona H., Randall Louise M., Haque Ashraful, Pellicci Daniel G., Hill Geoff R., Smyth Mark J., Godfrey Dale I., Engwerda Christian R., Muller Ingrid, Activation of Invariant NKT Cells Exacerbates Experimental Visceral Leishmaniasis, PLoS Pathogens, 4, 2, 2008. Crossref
-
Gois B. M., Peixoto R. F., Maciel B. L. L., Gomes J. A. S., de Azevedo F. L. A. A., Veras R. C., de Medeiros I. A., de Lima Grisi T. C. S., de Araújo D. A. M., do Amaral I. P. G., Keesen T. S. L., Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: An example of cell plasticity according to different disease scenarios, Scandinavian Journal of Immunology, 87, 6, 2018. Crossref
-
Pei Bo, Kronenberg Mitchell, Structure and Recognition of Antigens for Invariant NKT Cells, in Natural Killer T cells, 2012. Crossref
-
Parekh Vrajesh V., Lalani Saif, Kim Sungjune, Halder Ramesh, Azuma Miyuki, Yagita Hideo, Kumar Vipin, Wu Lan, Van Kaer Luc, PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells, The Journal of Immunology, 182, 5, 2009. Crossref
-
Ansari A. Wahid, Temblay Jeff N., Alyahya Syarifah H., Ashton-Rickardt Philip G., Serine Protease Inhibitor 6 Protects iNKT Cells from Self-Inflicted Damage, The Journal of Immunology, 185, 2, 2010. Crossref
-
Pei Bo, Speak Anneliese O., Shepherd Dawn, Butters Terry, Cerundolo Vincenzo, Platt Frances M., Kronenberg Mitchell, Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids, The Journal of Immunology, 186, 3, 2011. Crossref
-
Bogdanov Mikhail, Mileykovskaya Eugenia, Dowhan William, Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders, in Lipids in Health and Disease, 49, 2008. Crossref
-
Yang Feng-Ling, Yang Yu-Liang, Wu Shih-Hsiung, Structure and Function of Glycolipids in Thermophilic Bacteria, in The Molecular Immunology of Complex Carbohydrates-3, 705, 2011. Crossref
-
Nadas Janos, Li Chenglong, Wang Peng George, Computational Structure Activity Relationship Studies on the CD1d/Glycolipid/TCR Complex Using AMBER and AUTODOCK, Journal of Chemical Information and Modeling, 49, 2, 2009. Crossref
-
Bai Li, Constantinides Michael G., Thomas Seddon Y., Reboulet Rachel, Meng Fanyong, Koentgen Frank, Teyton Luc, Savage Paul B., Bendelac Albert, Distinct APCs Explain the Cytokine Bias of α-Galactosylceramide Variants In Vivo, The Journal of Immunology, 188, 7, 2012. Crossref
-
Meyer E. H., DeKruyff R. H., Umetsu D. T., iNKT Cells in Allergic Disease, in T Cell Activation by CD1 and Lipid Antigens, 314, 2007. Crossref
-
Vitner Einat B., The role of brain innate immune response in lysosomal storage disorders: fundamental process or evolutionary side effect?, FEBS Letters, 594, 22, 2020. Crossref
-
Bendelac Albert, Savage Paul B., Teyton Luc, The Biology of NKT Cells, Annual Review of Immunology, 25, 1, 2007. Crossref
-
Wingender Gerhard, Kronenberg Mitchell, Invariant natural killer T cells in the response to bacteria: the advent of specific antigens, Future Microbiology, 1, 3, 2006. Crossref
-
Xia Chengfeng, Zhou Dapeng, Liu Chengwen, Lou Yanyan, Yao Qingjia, Zhang Wenpeng, Wang Peng George, Thio-isoglobotrihexosylceramide, an Agonist for Activating Invariant Natural Killer T Cells, Organic Letters, 8, 24, 2006. Crossref
-
Wingender Gerhard, Kronenberg Mitchell, The Role of Invariant Natural Killer T Cells in Autoimmune Diseases, in The Autoimmune Diseases, 2020. Crossref
-
Bai Li, Sagiv Yuval, Liu Yang, Freigang Stefan, Yu Karl O. A., Teyton Luc, Porcelli Steven A., Savage Paul B., Bendelac Albert, Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen αGalCer, Proceedings of the National Academy of Sciences, 106, 25, 2009. Crossref
-
Tupin Emmanuel, Kinjo Yuki, Kronenberg Mitchell, The unique role of natural killer T cells in the response to microorganisms, Nature Reviews Microbiology, 5, 6, 2007. Crossref