Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
PD-1 and Autoimmunity
Get access
SINOPSIS
An initiating T cell response requires both costimulatory signaling and T cell receptor/MHC binding. The immune system balances positive and negative costimulatory signal pathways to activate and deactivate T cells. This review focuses primarily on PD-1 and its ligands, which form a crucial inhibitory costimulatory pathway for maintaining peripheral tolerance, and their contribution to autoimmunity. Since 1992, when PD-1 was isolated, many studies have described the physiological roles of PD-1 signaling, reported relationships between Pdcd-1 gene polymorphism and autoimmune diseases, and applied PD-1/PD-1 ligand modulation to clinical trials. This review summarizes recent advances and future therapeutic applications of PD-1 and its ligands to autoimmune diseases.
-
Collins Matthew H., Henderson Andrew J., Transcriptional regulation and T cell exhaustion, Current Opinion in HIV and AIDS, 9, 5, 2014. Crossref
-
Jiao Qingqing, Liu Cuiping, Yang Ziliang, Ding Qiang, Wang Miaomiao, Li Min, Zhu Tingting, Qian Hua, Li Wei, Tu Na, Fang Fumin, Ye Licai, Zhao Zuotao, Qian Qihong, Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene, International Journal of Genomics, 2014, 2014. Crossref
-
Burleson Stefanie C.M., Fick Robert B., Mannie Mark D., Olmstead Stephen G., Van Scott Michael R., The Immune Basis of Allergic Lung Disease, in Comparative Biology of the Normal Lung, 2015. Crossref
-
Anderson Ana C., Joller Nicole, Kuchroo Vijay K., Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation, Immunity, 44, 5, 2016. Crossref
-
Zhang Lanfang, Xia Chang-Qing, PD-1/PD-L1 Interaction Maintains Allogeneic Immune Tolerance Induced by Administration of Ultraviolet B-Irradiated Immature Dendritic Cells, Journal of Immunology Research, 2016, 2016. Crossref
-
Zhou Jing, Jin Jun-O., Kawai Toshihisa, Yu Qing, Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren’s syndrome in non-obese diabetic mice, Scientific Reports, 6, 1, 2016. Crossref
-
Rosinsky Carolyn, Antony Paul Andrew, A role for pre-mNK cells in tumor progression, Journal for ImmunoTherapy of Cancer, 4, 1, 2016. Crossref
-
Tsai Hwei-Fang, Hsu Ping-Ning, Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets, Journal of Biomedical Science, 24, 1, 2017. Crossref
-
Joller Nicole, Kuchroo Vijay K., Tim-3, Lag-3, and TIGIT, in Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity, 410, 2017. Crossref
-
Sharma Rahul, Kinsey Gilbert R., Regulatory T cells in acute and chronic kidney diseases, American Journal of Physiology-Renal Physiology, 314, 5, 2018. Crossref
-
Wang Yeshu, Zhang Qunfang, Chen Yuchao, Liang Chun-Ling, Liu Huazhen, Qiu Feifei, Dai Zhenhua, Antitumor effects of immunity-enhancing traditional Chinese medicine, Biomedicine & Pharmacotherapy, 121, 2020. Crossref
-
Kivisäkk Pia, Khoury Samia J., Co-signaling Molecules in Neurological Diseases, in Co-signal Molecules in T Cell Activation, 1189, 2019. Crossref
-
Konstantinovic Neda, Guegan Hélène, Stäjner Tijana, Belaz Sorya, Robert-Gangneux Florence, Treatment of toxoplasmosis: Current options and future perspectives, Food and Waterborne Parasitology, 15, 2019. Crossref
-
Hu Suiyuan, Liu Xu, Li Tianding, Li Zhanguo, Hu Fanlei, LAG3 (CD223) and autoimmunity: Emerging evidence, Journal of Autoimmunity, 112, 2020. Crossref
-
Jiang Xianghu, Liu Guohong, Li Yirong, Pan Yunbao, Immune checkpoint: The novel target for antitumor therapy, Genes & Diseases, 8, 1, 2021. Crossref
-
Huang Ruixue, Zhou Ping-Kun, DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy, Signal Transduction and Targeted Therapy, 6, 1, 2021. Crossref
-
Bassiouni Sherine A., Abdeen Hanaa M., Morsi Heba K., Zaki Maysaa E., Abdelsalam Maha, Gharbia Ola M., Programmed death 1 (PD-1) serum level and gene expression in recent onset systemic lupus erythematosus patients, The Egyptian Rheumatologist, 43, 3, 2021. Crossref
-
Bhadra Rajarshi, Cobb Dustin A., Khan Imtiaz A., Flynn J. L., Donor CD8 + T Cells Prevent Toxoplasma gondii De-Encystation but Fail To Rescue the Exhausted Endogenous CD8 + T Cell Population , Infection and Immunity, 81, 9, 2013. Crossref
-
d’Alessandro Miriana, Bergantini Laura, Mezzasalma Fabrizio, Cavallaro Dalila, Gangi Sara, Baglioni Stefano, Armati Martina, Abbritti Marta, Cattelan Stefano, Cameli Paolo, Bargagli Elena, Immune-Checkpoint Expression on CD4, CD8 and NK Cells in Blood, Bronchoalveolar Lavage and Lymph Nodes of Sarcoidosis, Molecular Diagnosis & Therapy, 26, 4, 2022. Crossref
-
Naeem Abid, Hu Pengyi, Yang Ming, Zhang Jing, Liu Yali, Zhu Weifeng, Zheng Qin, Natural Products as Anticancer Agents: Current Status and Future Perspectives, Molecules, 27, 23, 2022. Crossref