Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Class II Antigen Processing: Analysis of Compartments and Functions
SINOPSIS
The endocytic and phagocytic pathways are composed of a series of vesicular or vacuolar organelles within the cytoplasm in which exogenous proteins or particles are processed. This processing includes catabolism of protein antigens by proteases that exist within endosomes, lysosomes, phagosomes, and phagolysosomes. Antigen processing produces peptides that bind to class II MHC (MHC-II) molecules, which also target to vesicular compartments. Multiple different vesicular compartments may contribute to antigen processing, although some compartments appear to be specialized in order to perform certain antigen processing functions. The relative levels of MHC-II molecules, processing enzymes, and other specialized molecules (e.g., HLA-DM) are among the variables that determine the relative contribution of different compartments. Recent studies have begun to identify specific compartments that mediate certain antigen processing functions, including the binding of immunogenic peptides to MHC-II molecules.
-
Bryant Paula Wolf, Lennon-Duménil Ana-Maria, Fiebiger Edda, Lagaudriére-Gesbert Cécile, Ploegh Hidde L, , 80, 2002. Crossref
-
Liu Meng, Ai Hongxin, Xiao Wen, Shen Yuefen, Shen Yang, Cui Xianwei, Zhang Shuangquan, Identification of interferon-γ-inducible-lysosomal thiol reductase (GILT) gene from Mefugu (Takifugu obscures) and its immune response to LPS challenge, Developmental & Comparative Immunology, 41, 2, 2013. Crossref
-
Khan Arshad, Singh Christopher R., Soudani Emily, Bakhru Pearl, Saikolappan Sankaralingam, Cirillo Jeffrey D., Tony Eissa N., Dhandayuthapani Subramanian, Jagannath Chinnaswamy, Autophagy enhances the Efficacy of BCG Vaccine, in Autophagy, Infection, and the Immune Response, 2014. Crossref
-
Hayashi Kosuke, Yoshida Hideyoshi, Nishida Shin, Goto Mutsuo, Pastene Luis A., Kanda Naohisa, Baba Yoshiyuki, Koike Hiroko, Genetic Variation of the MHCDQBLocus in the Finless Porpoise (Neophocaena phocaenoides), Zoological Science, 23, 2, 2006. Crossref
-
Noss Erika H., Harding Clifford V., Boom W.Henry, Mycobacterium tuberculosis Inhibits MHC Class II Antigen Processing in Murine Bone Marrow Macrophages, Cellular Immunology, 201, 1, 2000. Crossref
-
Hayashi Kosuke, Nishida Shin, Yoshida Hideyoshi, Goto Mutsuo, Pastene Luis A., Koike Hiroko, Sequence variation of the DQB allele in the cetacean MHC., Mammal Study, 28, 2, 2003. Crossref
-
Harding Clifford V., Antigen Processing and Presentation, Current Protocols in Immunology, 77, 1, 2007. Crossref
-
Harding Clifford V., Ramachandra Lakshmi, Presenting Exogenous Antigen to T Cells, Current Protocols in Immunology, 88, 1, 2010. Crossref
-
Harding Clifford V., Presenting Exogenous Antigen to T Cells, Current Protocols in Immunology, 23, 1, 1997. Crossref
-
Kao K.J., Mechanisms and new approaches for the allogeneic blood transfusion-induced immunomodulatory effects, Transfusion Medicine Reviews, 14, 1, 2000. Crossref
-
Canaday David H., Chakravarti Soma, Srivastava Tarun, Tisch Daniel J., Cheruvu Vinay K., Smialek Jamie, Harding Clifford V., Ramachandra Lakshmi, Class II MHC antigen presentation defect in neonatal monocytes is not correlated with decreased MHC-II expression, Cellular Immunology, 243, 2, 2006. Crossref
-
Bonomi Giovanna, Moschella Federica, Ombra Maria Neve, Del Pozzo Giovanna, Granier Claude, De Berardinis Piergiuseppe, Guardiola John, Modulation of TCR recognition of MHC class II/peptide by processed remote N- and C-terminal epitope extensions, Human Immunology, 61, 8, 2000. Crossref
-
Pitcovski J., Bazak Z., Wasserman Elena, Elias Orit, Levy Adva, Peretz Tamar, Fingerut Elena, Frankenburg Shoshana, Heat labile enterotoxin of E. coli: a potential adjuvant for transcutaneous cancer immunotherapy, Vaccine, 24, 5, 2006. Crossref
-
Chen Liying, Jondal Mikael, Brefeldin A inhibits vesicular MHC class I processing in resting but not in CpG- and disruption-activated DC, Molecular Immunology, 46, 1, 2008. Crossref
-
Prisco Antonella, Bonomi Giovanna, Moschella Federica, Ombra Maria Neve, De Berardinis Piergiuseppe, Guardiola John, In vitro immunization with a recombinant antigen carrying the HIV-1 RT248–262 determinant inserted at different locations results in altered TCRVB region usage, Human Immunology, 60, 9, 1999. Crossref
-
Sun Yongliang, Chen Zhiqi, Chung Stephen W, Zeng H, Gorczynski Reginald M, TCR diversity in γδTCR+ hybridomas derived from mice given portal vein donor-specific pre-immunization and skin allografts, Immunology Letters, 64, 2-3, 1998. Crossref
-
Lich John D., Elliott John F., Blum Janice S., Cytoplasmic Processing Is a Prerequisite for Presentation of an Endogenous Antigen by Major Histocompatibility Complex Class II Proteins, Journal of Experimental Medicine, 191, 9, 2000. Crossref
-
Fineschi Beatrice, Miller Jim, Endosomal proteases and antigen processing, Trends in Biochemical Sciences, 22, 10, 1997. Crossref
-
Riquelme Sebastián A., Bueno Susan M., Kalergis Alexis M., IgG keeps virulent Salmonella from evading dendritic cell uptake, Immunology, 136, 3, 2012. Crossref
-
Vlad Anda M. , Muller Stefan , Cudic Mare , Paulsen Hans , Otvos Laszlo , Hanisch Franz-Georg , Finn Olivera J. , Complex Carbohydrates Are Not Removed During Processing of Glycoproteins by Dendritic Cells , Journal of Experimental Medicine, 196, 11, 2002. Crossref
-
Jagannath Chinnaswamy, Khan Arshad, Wang Jin, Increased Immunogenicity Through Autophagy, in Immunology, 2018. Crossref
-
Davidson H.W., Direct Transport of Newly Synthesized HLA-DR from the trans-Golgi Network to Major Histocompatibility Complex Class II Containing Compartments (MIICS) Demonstrated Using a Novel Tyrosine-sulfated Chimera, Journal of Biological Chemistry, 274, 38, 1999. Crossref
-
Dell'Angelica Esteban C., Mullins Chris, Caplan Steve, Bonifacino Juan S., Lysosome‐related organelles, The FASEB Journal, 14, 10, 2000. Crossref
-
Levine Bruce L, Schlienger Katia, June Carl H, T-Lymphocytes: Mature Polyclonal and Antigen-Specific Cell Culture, in Human Cell Culture, 4, 2002. Crossref
-
Hiltbold Elizabeth M., Vlad Anda M., Ciborowski Pawel, Watkins Simon C., Finn Olivera J., The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells, The Journal of Immunology, 165, 7, 2000. Crossref
-
O’Donnell Patrick W., Haque Azizul, Klemsz Michael J., Kaplan Mark H., Blum Janice S., Cutting Edge: Induction of the Antigen-Processing Enzyme IFN-γ-Inducible Lysosomal Thiol Reductase in Melanoma Cells Is STAT1-Dependent but CIITA-Independent, The Journal of Immunology, 173, 2, 2004. Crossref
-
Sinnathamby Gomathinayagam, Eisenlohr Laurence C., Presentation by Recycling MHC Class II Molecules of an Influenza Hemagglutinin-Derived Epitope That Is Revealed in the Early Endosome by Acidification, The Journal of Immunology, 170, 7, 2003. Crossref
-
Lich John D., Jayne Jennifer A., Zhou Delu, Elliott John F., Blum Janice S., Editing of an Immunodominant Epitope of Glutamate Decarboxylase by HLA-DM, The Journal of Immunology, 171, 2, 2003. Crossref
-
Harding Clifford V., Antigen Processing and Presentation, Current Protocols in Immunology, 37, 1, 2000. Crossref
-
Lizée Gregory, Gilliet Michel, Human Dendritic Cells in Cancer, in Innate Immune Regulation and Cancer Immunotherapy, 2012. Crossref
-
Dörfel Daniela, Appel Silke, Grünebach Frank, Weck Markus M., Müller Martin R., Heine Annkristin, Brossart Peter, Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro–transcribed MUC1 RNA, Blood, 105, 8, 2005. Crossref
-
Sato Aaron K., Zarutskie Jennifer A., Rushe Mia M., Lomakin Aleksey, Natarajan Sateesh K., Sadegh-Nasseri Scheherazade, Benedek George B., Stern Lawrence J., Determinants of the Peptide-induced Conformational Change in the Human Class II Major Histocompatibility Complex Protein HLA-DR1, Journal of Biological Chemistry, 275, 3, 2000. Crossref
-
Boehm U., Klamp T., Groot M., Howard J. C., CELLULAR RESPONSES TO INTERFERON-γ, Annual Review of Immunology, 15, 1, 1997. Crossref
-
Phelps Richard G., Jones Victoria L., Coughlan Mary, Turner A. Neil, Rees Andrew J., Presentation of the Goodpasture Autoantigen to CD4 T Cells Is Influenced More by Processing Constraints Than by HLA Class II Peptide Binding Preferences, Journal of Biological Chemistry, 273, 19, 1998. Crossref
-
Pless Dorothy D., Ruthel Gordon, Reinke Emily K., Ulrich Robert G., Bavari Sina, Persistence of Zinc-Binding Bacterial Superantigens at the Surface of Antigen-Presenting Cells Contributes to the Extreme Potency of These Superantigens as T-Cell Activators, Infection and Immunity, 73, 9, 2005. Crossref
-
Rovere Patrizia, Zimmermann Valérie S., Forquet Frédérique, Demandolx Denis, Trucy Jeannine, Ricciardi-Castagnoli Paola, Davoust Jean, Dendritic cell maturation and antigen presentation in the absence of invariant chain, Proceedings of the National Academy of Sciences, 95, 3, 1998. Crossref
-
Rüssmann Holger, Panthel Klaus, Köhn Brigitte, Jellbauer Stefan, Winter Sebastian E., Garbom Sara, Wolf-Watz Hans, Hoffmann Sigrid, Grauling-Halama Silke, Geginat Gernot, Alternative Endogenous Protein Processing via an Autophagy-Dependent Pathway Compensates for Yersinia -Mediated Inhibition of Endosomal Major Histocompatibility Complex Class II Antigen Presentation , Infection and Immunity, 78, 12, 2010. Crossref
-
de Haan Lolke, Hearn Arron R., Rivett A. Jennifer, Hirst Timothy R., Enhanced Delivery of Exogenous Peptides into the Class I Antigen Processing and Presentation Pathway, Infection and Immunity, 70, 6, 2002. Crossref
-
Bitsch Rebekka, Kurzay Annina, Özbay Kurt Feyza, De La Torre Carolina, Lasser Samantha, Lepper Alisa, Siebenmorgen Alina, Müller Verena, Altevogt Peter, Utikal Jochen, Umansky Viktor, STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice, Journal for ImmunoTherapy of Cancer, 10, 3, 2022. Crossref
-
Dai Yang, Carayanniotis Karen A., Eliades Petros, Lymberi Peggy, Shepherd Philip, Kong Yi-chi M., Carayanniotis George, Enhancing or Suppressive Effects of Antibodies on Processing of a Pathogenic T Cell Epitope in Thyroglobulin, The Journal of Immunology, 162, 12, 1999. Crossref
-
Lo-Man Richard, Langeveld Jan P. M., Martineau Pierre, Hofnung Maurice, Meloen Robert H., Leclerc Claude, Immunodominance Does Not Result from Peptide Competition for MHC Class II Presentation, The Journal of Immunology, 160, 4, 1998. Crossref
-
Chu Rose S., Askew David, Noss Erika H., Tobian Aaron, Krieg Arthur M., Harding Clifford V., CpG Oligodeoxynucleotides Down-Regulate Macrophage Class II MHC Antigen Processing, The Journal of Immunology, 163, 3, 1999. Crossref
-
Zimmermann Valérie S., Rovere Patrizia, Trucy Jeannine, Serre Karine, Machy Patrick, Forquet Frédérique, Leserman Lee, Davoust Jean, Engagement of B Cell Receptor Regulates the Invariant Chain-Dependent MHC Class II Presentation Pathway, The Journal of Immunology, 162, 5, 1999. Crossref
-
Knolle Percy A., Germann Tieno, Treichel Ulrich, Uhrig Anja, Schmitt Edgar, Hegenbarth Silke, Lohse Ansgar W., Gerken Guido, Endotoxin Down-Regulates T Cell Activation by Antigen-Presenting Liver Sinusoidal Endothelial Cells, The Journal of Immunology, 162, 3, 1999. Crossref