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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Biochemistry of Antigen Receptor Signaling in Mature and Developing B Lymphocytes

Volumen 17, Edición 3-4, 1997, pp. 353-385
DOI: 10.1615/CritRevImmunol.v17.i3-4.50
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SINOPSIS

The function of the surface antigen receptor of B cells (BCR) has been extensively studied with respect to the activation of mature B lymphocytes. B cells at other points of development (e.g., pre-B cells, immature B cells, and germinal center B cells) also express forms of the BCR, and for cells at these developmental timepoints, signaling through the BCR in some cases may lead to outcomes other than B-cell activation. Understanding the molecular events that are initiated by BCR crosslinking would enhance our understanding of the regulation and functional results of BCR signaling throughout B-cell development. In this article we review the current understanding of BCR signal transduction from initiation of the signal through changes in expression of genes that regulate the activation state. Costimulatory and modulatory molecules are considered with regard to their ability to affect the sensitivity or outcome of the BCR signal. Finally, we discuss how BCR signal transduction and the results of BCR signaling may differ at distinct stages in B-cell development.

CITADO POR
  1. Craxton Andrew, Otipoby Kevin L., Jiang Aimin, Clark Edward A., , 73, 1999. Crossref

  2. Ross David A., Wilson Melanie R., Miller Norman W, Clem L. William, Warr Gregory W, Ross David A., Wilson Melanie R., Miller Normon W., Clem L. William, Warr Gregory W., Evolutionary variation of immunoglobulin mu heavy chain RNA processing pathways: origins, effects, and implications, Immunological Reviews, 166, 1, 1998. Crossref

  3. Bertrand Fred E., Golub Rachel, Wu Gillian E., VH gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice, European Journal of Immunology, 28, 10, 1998. Crossref

  4. Campbell Kerry S, Signal transduction from the B cell antigen-receptor, Current Opinion in Immunology, 11, 3, 1999. Crossref

  5. Dreyling Martin, Hoster Eva, Bea Silvia, Hartmann Elena, Horn Heike, Hutter Grit, Salaverria Itziar, Pott Christiane, Trneny Marek, Le Gouill Steven, Cortelazzo Sergio, Szymczyk Michal, Jurczak Wojciech, Shpilberg Ofer, Ribrag Vincent, Hermine Olivier, Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference, Leukemia & Lymphoma, 51, 9, 2010. Crossref

  6. Diamond Betty, Grimaldi Christine, B Cells, in Kelley's Textbook of Rheumatology, 2009. Crossref

  7. Zidovetzki Raphael, Rost Burkhard, Pecht Israel, Role of transmembrane domains in the functions of B- and T-cell receptors, Immunology Letters, 64, 2-3, 1998. Crossref

  8. Venkataraman C, Chelvarajan R.L, Cambier J.C, Bondada S, Interleukin-4 overcomes the negative influence of cyclic amp accumulation on antigen receptor stimulated B lymphocytes, Molecular Immunology, 35, 14-15, 1998. Crossref

  9. Peckham David, Andersen-Nissen Erica, Finkelman Fred D., Stunz Laura L., Ashman Robert F., Difference in apoptosis induction between surface IgD and IgM, International Immunology, 13, 3, 2001. Crossref

  10. Swart Jennifer M., Bergeron Daniele M., Chiles Thomas C., Identification of a Membrane Ig-Induced p38 Mitogen-Activated Protein Kinase Module That Regulates cAMP Response Element Binding Protein Phosphorylation and Transcriptional Activation in CH31 B Cell Lymphomas, The Journal of Immunology, 164, 5, 2000. Crossref

  11. Cockayne Debra A., Muchamuel Tony, Grimaldi J. Christopher, Muller-Steffner Hélène, Randall Troy D., Lund Frances E., Murray Richard, Schuber Francis, Howard Maureen C., Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses, Blood, 92, 4, 1998. Crossref

  12. Krieg A. M., Hartmann G., Yi A.-K., Mechanism of Action of CpG DNA, in Immunobiology of Bacterial CpG-DNA, 247, 2000. Crossref

  13. Bradl Harald, Jäck Hans-Martin, Surrogate Light Chain-Mediated Interaction of a Soluble Pre-B Cell Receptor with Adherent Cell Lines, The Journal of Immunology, 167, 11, 2001. Crossref

  14. Wienands J., The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins, in Signal Transduction and the Coordination of B Lymphocyte Development and Function I, 245/1, 2000. Crossref

  15. da Cruz L. A. G., Penfold S., Zhang J., Somani A.-K., Shi F., McGavin M. K. H., Song X., Siminovitch Katherine A., Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling, in Signal Transduction and the Coordination of B Lymphocyte Development and Function I, 245/1, 2000. Crossref

  16. Gold M. R., Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus, in Signal Transduction and the Coordination of B Lymphocyte Development and Function I, 245/1, 2000. Crossref

  17. Cockayne Debra A., Muchamuel Tony, Grimaldi J. Christopher, Muller-Steffner Hélène, Randall Troy D., Lund Frances E., Murray Richard, Schuber Francis, Howard Maureen C., Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses, Blood, 92, 4, 1998. Crossref

  18. Morschhauser F., Seymour J.F., Kluin-Nelemans H.C., Grigg A., Wolf M., Pfreundschuh M., Tilly H., Raemaekers J., van ’t Veer M.B., Milpied N., Cartron G., Pezzutto A., Spencer A., Reyes F., Dreyling M., A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma, Annals of Oncology, 19, 2, 2008. Crossref

  19. Sigalov Alexander, Aivazian Dikran, Stern Lawrence, Homooligomerization of the Cytoplasmic Domain of the T Cell Receptor ζ Chain and of Other Proteins Containing the Immunoreceptor Tyrosine-Based Activation Motif, Biochemistry, 43, 7, 2004. Crossref

  20. Krieg Arthur M., CpG Motifs in Bacterial DNA and Their Immune Effects, Annual Review of Immunology, 20, 1, 2002. Crossref

  21. Gachlin Gabriel, Michelin Olivier, Luescher Immanuel F, Cambiaggi Anna, Antigen Recognition by Lymphocytes, in eLS, 2001. Crossref

  22. Banerji Lolita, Glassford Janet, Lea Nicholas C, Thomas N Shaun B, Klaus Gerry G B, Lam Eric W-F, BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells, Oncogene, 20, 50, 2001. Crossref

  23. Fujimoto Manabu, Poe Jonathan C., Jansen Paul J., Sato Shinichi, Tedder Thomas F., CD19 Amplifies B Lymphocyte Signal Transduction by Regulating Src-Family Protein Tyrosine Kinase Activation, The Journal of Immunology, 162, 12, 1999. Crossref

  24. Berland Robert, Wortis Henry H., An NFAT-Dependent Enhancer Is Necessary for Anti-IgM-Mediated Induction of Murine CD5 Expression in Primary Splenic B Cells, The Journal of Immunology, 161, 1, 1998. Crossref

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