Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Microbial Products and Cytokines in Sleep and Fever Regulation
SINOPSIS
Excessive sleepiness and fever are constitutional symptoms associated with systemic infection. Although fevers have been investigated for many years, sleep responses to infectious challenge have only recently been investigated. Inoculation of animals with bacterial, viral, protozoan and fungal organisms result in complex sleep responses dependent upon the microbial agent and route of administration. The general pattern is characterized by an initial robust increase in non-rapid eye movement sleep (NREMS) followed by a period of NREMS inhibition. REMS is inhibited after infectious challenge. The sleep responses are accompanied by fever but the two responses are, in part, independent from each other. Sleep responses, like fevers, may be beneficial to host defense although this area is relatively uninvestigated. Microbial products likely responsible for sleep and fever responses include bacterial muramyl peptides and endotoxin, and viral double stranded RNA. These microbial products induce sleep and fever responses in animal models. The exact mechanism of how these structurally diverse microbial products elicit sleep and fever remain unknown; however these substances share the ability to induce cytokine production. Cytokines such as interleukin-1 (IL-1), tumor necrosis factor, acidic fibroblast growth factor (FGF), and interferon-α (IFN-α) are somnogenic whether given directly into brain or intravenously. Other cytokines lack somnogenic activity, e.g., IL-2, IL-6, IFNβ and basic FGF. The somnogenic actions of cytokines probably involve growth hormone-releasing hormone (GHRH) and nitric oxide. Anti-GHRH or inhibition of NO production inhibits normal sleep and inhibits IL-1-induced sleep. In conclusion, cytokines are likely key mediators of fever and sleep responses to infection. The microbial-cytokine altered sleep likely results from an amplification of physiological sleep mechanisms which include cytokines, several neuropeptides and neurotransmitters such as nitric oxide.
-
Tringali Giuseppe, Dello Russo Cinzia, Preziosi Paolo, Navarra Pierluigi, Hypothalamic interleukin-1 in physiology and pathology, Toxicology Letters, 102-103, 1998. Crossref
-
Rama Anil N., Charles Cho S., Kushida Clete A., , 6, 2005. Crossref
-
Marshall Lisa, Born Jan, Brain-Immune interactions in sleep, in Neurobiology of the Immune System, 52, 2002. Crossref
-
Kimura Mayumi, Kodama Tohru, Honda Yoshiko, Zhang Shi‐Qing, Inoué Shojiro, Colony‐stimulating factors in rapid eye movement sleep and non‐rapid eye movement sleep regulation, Psychiatry and Clinical Neurosciences, 53, 2, 1999. Crossref
-
Garcia-Garcia Fabio, Yoshida Hitoshi, Krueger James M., Interleukin-8 promotes non-rapid eye movement sleep in rabbits and rats, Journal of Sleep Research, 13, 1, 2004. Crossref
-
Ek Monica, Arias Carlos, Sawchenko Paul, Ericsson-Dahlstrand Anders, Distribution of the EP3 prostaglandin E2 receptor subtype in the rat brain: Relationship to sites of interleukin-1-induced cellular responsiveness, The Journal of Comparative Neurology, 428, 1, 2000. Crossref
-
Bryant Penelope A., Trinder John, Curtis Nigel, Sick and tired: does sleep have a vital role in the immune system?, Nature Reviews Immunology, 4, 6, 2004. Crossref
-
Chokroverty Sudhansu, Características generales del sueño normal, in Medicina de los Trastornos del Sueño, 2011. Crossref
-
LINTHORST ASTRID C. E., REUL JOHANNES M. H. M., Brain Neurotransmission during Peripheral Inflammationa, Annals of the New York Academy of Sciences, 840, 1, 1998. Crossref
-
Fang Jidong, Krueger James, Cytokines and Sleep Regulation, in Handbook of Behavioral State Control, 1998. Crossref
-
Kronfol Ziad, Depression and Immunity, in Cytokines, 1998. Crossref
-
Imeri Luca, Grazia de Simoni Maria, Immune Alterations in Neurotransmission, in Handbook of Behavioral State Control, 1998. Crossref
-
Toth Linda, Microbial Modulation of Arousal, in Handbook of Behavioral State Control, 1998. Crossref
-
Shiromani Priyattam, Saper Clifford, Scammell Tom, Sherin John, Hypothalamic Regulation of Sleep, in Handbook of Behavioral State Control, 1998. Crossref
-
Dunn Adrian J, The Cytokines and Depression Hypothesis: An Evaluation, in Cytokines and the Brain, 6, 2008. Crossref
-
Chaskiel Léa, Konsman Jan Pieter, Brain Interleukin-1β Expression and Action in the Absence of Neuropathology, in Cytokines and the Brain, 6, 2008. Crossref
-
Pillemer Stanley R., Bradley Laurence A., Crofford Leslie J., Moldofsky Harvey, Chrousos George P., The neuroscience and endocrinology of fibromyalgia, Arthritis & Rheumatism, 40, 11, 1997. Crossref
-
KRUEGER JAMES M., TAKAHASHI SATOSHI, Thermoregulation and Sleep., Annals of the New York Academy of Sciences, 813, 1 Thermoregulat, 1997. Crossref
-
Fang Jidong, Krueger James, Cytokines and Sleep Regulation, in Handbook of Behavioral State Control, 1998. Crossref
-
Chokroverty Sudhansu, An Overview of Normal Sleep, in Sleep Disorders Medicine, 2009. Crossref
-
Larson Susan J., Dunn Adrian J., Behavioural Mechanisms for Defence Against Pathogens, in Natural Immunity, 5, 2005. Crossref
-
Shiromani Priyattam, Saper Clifford, Scammell Tom, Sherin John, Hypothalamic Regulation of Sleep, in Handbook of Behavioral State Control, 1998. Crossref
-
Lashley Felissa R., A Review of Sleep in Selected Immune and Autoimmune Disorders, Holistic Nursing Practice, 17, 2, 2003. Crossref
-
Chen Yun-Hsiang, Huang Yu-Shu, Chen Chia-Hsiang, Increased plasma level of tumor necrosis factor α in patients with narcolepsy in Taiwan, Sleep Medicine, 14, 12, 2013. Crossref
-
Graff G.R., Gozal D., Cardiorespiratory Responses to Interleukin-1β in Adult Rats: Role of Nitric Oxide, Eicosanoids and Glucocorticoids, Archives of Physiology and Biochemistry, 107, 2, 1999. Crossref
-
Krueger , Obál, Jr , Fang , Humoral regulation of physiological sleep: cytokines and GHRH, Journal of Sleep Research, 8, S1, 1999. Crossref
-
Schmidt Eva-Maria, Linz Barbara, Diekelmann Susanne, Besedovsky Luciana, Lange Tanja, Born Jan, Effects of an interleukin-1 receptor antagonist on human sleep, sleep-associated memory consolidation, and blood monocytes, Brain, Behavior, and Immunity, 47, 2015. Crossref
-
Moldofsky Harvey, Dickstein Jodi B, REVIEW ARTICLE: Sleep and cytokine–immune functions in medical, psychiatric and primary sleep disorders, Sleep Medicine Reviews, 3, 4, 1999. Crossref
-
Tizard Ian, Sickness behavior, its mechanisms and significance, Animal Health Research Reviews, 9, 1, 2008. Crossref
-
Haack Monika, Schuld Andreas, Kraus Thomas, Pollmächer Thomas, Effects of Sleep on Endotoxin-Induced Host Responses in Healthy Men, Psychosomatic Medicine, 63, 4, 2001. Crossref
-
Alt Jeremiah A., Smith Timothy L., Schlosser Rodney J., Mace Jess C., Soler Zachary M., Sleep and quality of life improvements after endoscopic sinus surgery in patients with chronic rhinosinusitis, International Forum of Allergy & Rhinology, 4, 9, 2014. Crossref
-
CHIANG EDDIE T., PERSAUD-SAWIN DIXIE-ANN, KULKARNI SANDHYA, GARCIA JOE G. N., IMANI FARHAD, Bluetongue Virus and Double-Stranded RNA Increase Human Vascular Permeability: Role of p38 MAPK, Journal of Clinical Immunology, 26, 4, 2006. Crossref
-
Bailey Michael, Engler Harald, Hunzeker John, Sheridan John F., The Hypothalamic-Pituitary-Adrenal Axis and Viral Infection, Viral Immunology, 16, 2, 2003. Crossref
-
Stack Edward C., Desarnaud Frank, Siwek Donald F., Datta Subimal, A novel role for calcium/calmodulin kinase II within the brainstem pedunculopontine tegmentum for the regulation of wakefulness and rapid eye movement sleep, Journal of Neurochemistry, 112, 1, 2010. Crossref
-
Krueger James M., Obál Ferenc, Fang Jidong, Kubota Takeshi, Taishi Ping, The Role of Cytokines in Physiological Sleep Regulation, Annals of the New York Academy of Sciences, 933, 1, 2006. Crossref
-
Majde Jeannine A., Viral Double-Stranded RNA, Cytokines, and the Flu, Journal of Interferon & Cytokine Research, 20, 3, 2000. Crossref
-
KRUEGER JAMES M., MAJDE JEANNINE A., Humoral Links between Sleep and the Immune System, Annals of the New York Academy of Sciences, 992, 1, 2003. Crossref
-
Vitkovic Ljubisa, Bockaert Joël, Jacque Claude, “Inflammatory” Cytokines, Journal of Neurochemistry, 74, 2, 2001. Crossref
-
Obál Ferenc, Krueger James M., Hormones, Cytokines, and Sleep, in Comprehensive Physiology, 2001. Crossref
-
Hansen Michael K, Nguyen Kien T, Goehler Lisa E, Gaykema Ron P.A, Fleshner Monika, Maier Steven F, Watkins Linda R, Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1β protein in rats, Autonomic Neuroscience, 85, 1-3, 2000. Crossref
-
Moesby Lise, Hansen Erik W, Christensen Jens D, Ultrasonication of pyrogenic microorganisms improves the detection of pyrogens in the Mono Mac 6 assay, European Journal of Pharmaceutical Sciences, 11, 1, 2000. Crossref
-
Ilyin Sergey E, Gayle Dave, Flynn Mark C, Plata-Salamán Carlos R, Interleukin-1β System (Ligand, Receptor Type I, Receptor Accessory Protein and Receptor Antagonist), TNF-α, TGF-β1 and Neuropeptide Y mRNAs in Specific Brain Regions During Bacterial LPS-Induced Anorexia, Brain Research Bulletin, 45, 5, 1998. Crossref
-
Krueger James M, Majde Jeannine A, Obál Ferenc, Sleep in host defense, Brain, Behavior, and Immunity, 17, 1, 2003. Crossref
-
Dunlop Robert J, Campbell Colin W, Cytokines and Advanced Cancer, Journal of Pain and Symptom Management, 20, 3, 2000. Crossref
-
Francis Joseph, MohanKumar P.S., MohanKumar Sheba M.J., Lipopolysaccharide stimulates norepinephrine efflux from the rat hypothalamus in vitro: blockade by soluble IL-1 receptor, Neuroscience Letters, 308, 2, 2001. Crossref
-
Vodovnik L., Miklavcic D., Kotnik T., Electrical neuroimmunomodulation-a possible mechanism for wound and cancer treatment, Proceedings of the 2nd International Conference on Bioelectromagnetism (Cat. No.98TH8269), 1998. Crossref
-
Garcı́a-Garcı́a Fabio, Drucker-Colı́n René, Endogenous and exogenous factors on sleep–wake cycle regulation, Progress in Neurobiology, 58, 4, 1999. Crossref
-
Ashman Robert B., Fever, in Encyclopedia of Immunology, 1998. Crossref
-
Hansen Michael K, Krueger James M, Subdiaphragmatic vagotomy does not block sleep deprivation-induced sleep in rats, Physiology & Behavior, 64, 3, 1998. Crossref
-
Wieczorek Marek, Dunn Adrian J., Effect of subdiaphragmatic vagotomy on the noradrenergic and HPA axis activation induced by intraperitoneal interleukin-1 administration in rats, Brain Research, 1101, 1, 2006. Crossref
-
Langhans Wolfgang, Bacterial products and the control of ingestive behavior: Clinical implications, Nutrition, 12, 5, 1996. Crossref
-
Gemma C, Opp M.R, Human immunodeficiency virus glycoproteins 160 and 41 alter sleep and brain temperature of rats, Journal of Neuroimmunology, 97, 1-2, 1999. Crossref
-
Fosset Sophie, Fromentin Gilles, Rampin Olivier, Lang Vincent, Mathieu Florence, Tomé Daniel, Pharmacokinetics and feeding responses to muramyl dipeptide in rats, Physiology & Behavior, 79, 2, 2003. Crossref
-
Avitsur Ronit, Cohen Edna, Yirmiya Raz, Effects of Interleukin-1 on Sexual Attractivity in a Model of Sickness Behavior, Physiology & Behavior, 63, 1, 1997. Crossref
-
Waleh N.S., Apte-Deshpande A., Terao A., Ding J., Kilduff T.S., Modulation of the promoter region of prepro-hypocretin by α-interferon, Gene, 262, 1-2, 2001. Crossref
-
Kubota Takeshi, Majde Jeannine A, Brown Richard A, Krueger James M, Tumor necrosis factor receptor fragment attenuates interferon-γ-induced non-REM sleep in rabbits, Journal of Neuroimmunology, 119, 2, 2001. Crossref
-
Langhans Wolfgang, Anorexia of infection: current prospects, Nutrition, 16, 10, 2000. Crossref
-
Gelir Ethem, Oktay Arslan Seyfullah, Sayan Hale, Pinar Lamia, Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins, Prostaglandins, Leukotrienes and Essential Fatty Acids, 73, 5, 2005. Crossref
-
Nelson E A S, Wong Yin, Yu Ly Mee, Fok Tai Fai, Li Karen, Effects of Hyperthermia and Muramyl Dipeptide on IL-1β, IL-6, and Mortality in a Neonatal Rat Model, Pediatric Research, 52, 6, 2002. Crossref
-
Bickel Ulrich, Grave Birgit, Kang Young-Sook, del Rey Adriana, Voigt Karlheinz, No increase in blood–brain barrier permeability after intraperitoneal injection of endotoxin in the rat, Journal of Neuroimmunology, 85, 2, 1998. Crossref
-
KAPÁS LEVENTE, KRUEGER JAMES M, Nitric Oxide Donors SIN-1 and SNAP Promote Nonrapid-Eye-Movement Sleep in Rats, Brain Research Bulletin, 41, 5, 1996. Crossref
-
Tringali Giuseppe, Mancuso Cesare, Mirtella Adriana, Pozzoli Giacomo, Parente Luca, Preziosi Paolo, Navarra Pierluigi, Evidence for the neuronal origin of immunoreactive interleukin-1β released by rat hypothalamic explants, Neuroscience Letters, 219, 3, 1996. Crossref
-
Richardson Gary S., Human physiological models of insomnia, Sleep Medicine, 8, 2007. Crossref
-
Watkins Linda R., Hansen Michael K., Nguyen Kien T., Lee Jacqueline E., Maier Steven F., Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologists, Life Sciences, 65, 5, 1999. Crossref
-
Trachtman Joseph N., Vision and the hypothalamus, Optometry - Journal of the American Optometric Association, 81, 2, 2010. Crossref
-
Szymusiak Ronald, Gvilia Irma, Neurophysiology and Neurochemistry of Hypersomnia, Sleep Medicine Clinics, 7, 2, 2012. Crossref
-
Etet Paul F. Seke, Palomba Maria, Colavito Valeria, Grassi-Zucconi Gigliola, Bentivoglio Marina, Bertini Giuseppe, Sleep and Rhythm Changes at the Time ofTrypanosoma bruceiInvasion of the Brain Parenchyma in the Rat, Chronobiology International, 29, 4, 2012. Crossref
-
Kohyama Jun, Sleep as a window on the developing brain, Current Problems in Pediatrics, 28, 3, 1998. Crossref
-
Rehman Abdur, Taishi Ping, Fang Jidong, Majde Jeannine A., Krueger James M., THE CLONING OF A RAT PEPTIDOGLYCAN RECOGNITION PROTEIN (PGRP) AND ITS INDUCTION IN BRAIN BY SLEEP DEPRIVATION, Cytokine, 13, 1, 2001. Crossref
-
Kushikata Tetsuya, Takahashi Satoshi, Wang Ying, Fang Jidong, Krueger James M, An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits, Neuroscience Letters, 244, 3, 1998. Crossref
-
Basheer Radhika, Strecker Robert E., Thakkar Mahesh M., McCarley Robert W., Adenosine and sleep–wake regulation, Progress in Neurobiology, 73, 6, 2004. Crossref
-
Krueger James M., Majde Jeannine A., Host Defense, in Principles and Practice of Sleep Medicine, 2005. Crossref
-
Pollak Yehuda, Ovadia Haim, Goshen Inbal, Gurevich Ronnie, Monsa Keren, Avitsur Ronit, Yirmiya Raz, Behavioral aspects of experimental autoimmune encephalomyelitis, Journal of Neuroimmunology, 104, 1, 2000. Crossref
-
Raison Charles L., Rye David B., Woolwine Bobbi J., Vogt Gerald J., Bautista Breanne M., Spivey James R., Miller Andrew H., Chronic Interferon-Alpha Administration Disrupts Sleep Continuity and Depth in Patients with Hepatitis C: Association with Fatigue, Motor Slowing, and Increased Evening Cortisol, Biological Psychiatry, 68, 10, 2010. Crossref
-
Dunn Adrian J., Effects of cytokines and infections on brain neurochemistry, Clinical Neuroscience Research, 6, 1-2, 2006. Crossref
-
Basheer R, Rainnie D.G, Porkka-Heiskanen T, Ramesh V, McCarley R.W, Adenosine, prolonged wakefulness, and A1-activated NF-κB DNA binding in the basal forebrain of the rat, Neuroscience, 104, 3, 2001. Crossref
-
Dantzer Robert, Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity, European Journal of Pharmacology, 500, 1-3, 2004. Crossref
-
Avitsur Ronit, Pollak Yehuda, Yirmiya Raz, Different receptor mechanisms mediate the effects of endotoxin and interleukin-1 on female sexual behavior, Brain Research, 773, 1-2, 1997. Crossref
-
Larson Susan J., Dunn Adrian J., Behavioral Effects of Cytokines, Brain, Behavior, and Immunity, 15, 4, 2001. Crossref
-
Opp Mark R., Toth Linda A., Somnogenic and pyrogenic effects of interleukin-1β and lipopolysaccharide in intact and vagotomized rats, Life Sciences, 62, 10, 1998. Crossref
-
Krueger James M., Majde Jeannine A., Rector David M., Cytokines in immune function and sleep regulation, in Sleep Disorders, 98, 2011. Crossref
-
Turrin Nicolas P., Plata-Salamán Carlos R., Polyunsaturated Fatty Acids and Disease-associated and Cytokine-induced Neurological Manifestations, Nutritional Neuroscience, 1, 6, 1998. Crossref
-
Raison Charles L, Miller Andrew H, Pathogen–Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance, Neuropsychopharmacology, 42, 1, 2017. Crossref
-
Neumann H., Schmidt H., Cavalié A., Jenne D., Wekerle H., Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α, Journal of Experimental Medicine, 185, 2, 1997. Crossref
-
Almeida Maria C, Steiner Alexandre A, Branco Luiz G S, Romanovsky Andrej A, Aballay Alejandro, Neural Substrate of Cold-Seeking Behavior in Endotoxin Shock, PLoS ONE, 1, 1, 2006. Crossref
-
Alt Jeremiah A., Mace Jess C., Smith Timothy L., Soler Zachary M., Endoscopic sinus surgery improves cognitive dysfunction in patients with chronic rhinosinusitis, International Forum of Allergy & Rhinology, 6, 12, 2016. Crossref
-
Pillemer Stanley R., SLEEP SEGMENT, Journal of Musculoskeletal Pain, 6, 3, 1998. Crossref
-
Krueger James M., Karnovsky Manfred L., Sleep as a neuroimmune phenomenon: A brief historical perspective, Advances in Neuroimmunology, 5, 1, 1995. Crossref
-
Alt Jeremiah A., Ramakrishnan Vijay R., Platt Michael P., Kohli Preeti, Storck Kristina A., Schlosser Rodney J., Soler Zachary M., Sleep quality outcomes after medical and surgical management of chronic rhinosinusitis, International Forum of Allergy & Rhinology, 7, 2, 2017. Crossref
-
Krueger James M., Animal Models of Sleep, Journal of Musculoskeletal Pain, 6, 3, 1998. Crossref
-
Park Kyoung-Ho, Cho Seung-Ho, Song Chang-Eun, Kim Dong-Hyun, Kim Hyung-Tae, Neuroimmunological activation of the afferent laryngeal neural circuit in experimentally induced laryngeal inflammation, Acta Oto-Laryngologica, 125, 2, 2005. Crossref
-
Mullington Janet, Korth Carsten, Hermann Dirk M., Orth Armin, Galanos Chris, Holsboer Florian, Pollmächer Thomas, Dose-dependent effects of endotoxin on human sleep, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 278, 4, 2000. Crossref
-
Nadjar Agnes, Wigren Henna-Kaisa M., Tremblay Marie-Eve, Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders, Frontiers in Cellular Neuroscience, 11, 2017. Crossref
-
Hansen Michael K., Nguyen Kien T., Fleshner Monika, Goehler Lisa E., Gaykema Ron P. A., Maier Steven F., Watkins Linda R., Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 278, 2, 2000. Crossref
-
Fang Jidong, Wang Ying, Krueger James M., Effects of interleukin-1β on sleep are mediated by the type I receptor, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 274, 3, 1998. Crossref
-
Chokroverty Sudhansu, Overview of Normal Sleep, in Sleep Disorders Medicine, 2017. Crossref
-
Chen Lichao, Duricka Deborah, Nelson Scott, Mukherjee Sanjib, Bohnet Stewart G., Taishi Ping, Majde Jeannine A., Krueger James M., Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases, Journal of Applied Physiology, 97, 1, 2004. Crossref
-
Yirmiya Raz, Behavioral and psychological effects of immune activation, Current Opinion in Psychiatry, 10, 6, 1997. Crossref
-
Takahashi Satoshi, Kapás Levente, Fang Jidong, Krueger James M., Somnogenic relationships between tumor necrosis factor and interleukin-1, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 276, 4, 1999. Crossref
-
Wann BP, Bah TM, Kaloustian S, Boucher M, Dufort AM, Le Marec N, Godbout R, Rousseau G, Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline, Journal of Psychopharmacology, 23, 4, 2009. Crossref
-
Schneider L., Anatomy and Physiology of Normal Sleep, in Sleep and Neurologic Disease, 2017. Crossref
-
Imeri Luca, Bianchi Susanna, Mancia Mauro, Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 273, 5, 1997. Crossref
-
McDonald Fiona B., Chandrasekharan Kumaran, Wilson Richard J. A., Hasan Shabih U., Interactive effects of maternal cigarette smoke, heat stress, hypoxia, and lipopolysaccharide on neonatal cardiorespiratory and cytokine responses, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 311, 6, 2016. Crossref
-
Jhaveri K. A., Ramkumar V., Trammell R. A., Toth L. A., Spontaneous, homeostatic, and inflammation-induced sleep in NF-κB p50 knockout mice, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 291, 5, 2006. Crossref
-
Chen Zutang, Gardi Janos, Kushikata Tetsuya, Fang Jidong, Krueger James M., Nuclear factor-κB-like activity increases in murine cerebral cortex after sleep deprivation, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 276, 6, 1999. Crossref
-
Traub Stephanie, von Aulock Sonja, Hartung Thomas, Hermann Corinna, Invited review: MDP and other muropeptides — direct and synergistic effects on the immune system, Journal of Endotoxin Research, 12, 2, 2006. Crossref
-
Hansen Michael K., Taishi Ping, Chen Zutang, Krueger James M., Cafeteria feeding induces interleukin-1β mRNA expression in rat liver and brain, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 274, 6, 1998. Crossref
-
Alt Jeremy A., Obal Ferenc, Traynor T. R., Gardi Janos, Majde Jeannine A., Krueger James M., Alterations in EEG activity and sleep after influenza viral infection in GHRH receptor-deficient mice, Journal of Applied Physiology, 95, 2, 2003. Crossref
-
Krueger James M., Fang Jidong, Hansen Michael K., Zhang Jianyi, Obál Ferenc, Humoral Regulation of Sleep, Physiology, 13, 4, 1998. Crossref
-
Kushikata Tetsuya, Fang Jidong, Krueger James M., Interleukin-10 Inhibits Spontaneous Sleep in Rabbits, Journal of Interferon & Cytokine Research, 19, 9, 1999. Crossref
-
Kushikata Tetsuya, Fang Jidong, Wang Ying, Krueger James M., Interleukin-4 inhibits spontaneous sleep in rabbits, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 275, 4, 1998. Crossref
-
Taishi Ping, Bredow Sebastian, Guha-Thakurta Nandita, Obál Ferenc, Krueger James M, Diurnal variations of interleukin-1β mRNA and β-actin mRNA in rat brain, Journal of Neuroimmunology, 75, 1-2, 1997. Crossref
-
Kapás Levente, Hansen Michael K., Chang Hee-Yoon, Krueger James M., Vagotomy attenuates but does not prevent the somnogenic and febrile effects of lipopolysaccharide in rats, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 274, 2, 1998. Crossref
-
Kubota Takeshi, Kushikata Tetsuya, Fang Jidong, Krueger James M., Nuclear factor-κB inhibitor peptide inhibits spontaneous and interleukin-1β-induced sleep, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 279, 2, 2000. Crossref
-
TAISHI PING, CHEN ZUTANG, OBÁL FERENC, HANSEN MICHAEL K., ZHANG JIANYI, FANG JIDONG, KRUEGER JAMES M., Sleep-Associated Changes in Interleukin-1β mRNA in the Brain, Journal of Interferon & Cytokine Research, 18, 9, 1998. Crossref
-
Wieczorek S., Dahmen N., Kasten M., Epplen J.T., Gencik M., A rare form of narcolepsy (HLA-DR2???) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms, Psychiatric Genetics, 14, 1, 2004. Crossref
-
Garami Andras, Steiner Alexandre A., Romanovsky Andrej A., Fever and hypothermia in systemic inflammation, in Thermoregulation: From Basic Neuroscience to Clinical Neurology, Part II, 157, 2018. Crossref
-
Vena Catherine, Parker Kathy, Cunningham Mary, Clark Jane, McMillan Susan, Sleep-Wake Disturbances in People With Cancer Part I: An Overview of Sleep, Sleep Regulation, and Effects of Disease and Treatment, Oncology Nursing Forum, 31, 4, 2004. Crossref
-
Besedovsky Luciana, Lange Tanja, Haack Monika, The Sleep-Immune Crosstalk in Health and Disease, Physiological Reviews, 99, 3, 2019. Crossref
-
Henriksen S. J., Prospero-Garcia O., Phillips T. R., Fox H. S., Bloom F. E., Elder J. H., Feline Immunodeficiency Virus as a Model for Study of Lentivirus Infection of the Central Nervous System, in HIV and Dementia, 202, 1995. Crossref
-
Dunn Adrian J., Effects of Cytokines on Cerebral Neurotransmission and Potential Relationships to Function, in Cytokines and Mental Health, 7, 2003. Crossref
-
Krueger James M., Churchill Lynn, Cytokines and Sleep Regulation, in Cytokines and Mental Health, 7, 2003. Crossref
-
Szelényi J., Vizi E.S., Neuroimmune Correlates of Sleep in Depression: Role of Cytokines, in Neuroimmunology of Sleep, 2007. Crossref
-
Kushikata Tetsuya, Yoshida Hitoshi, Yasuda Tadanobu, Cytokines and Sleep: Neuro-Immune Interactions and Regulations, in Neuroimmunology of Sleep, 2007. Crossref
-
Koob George F., Colrain Ian M., Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework, Neuropsychopharmacology, 45, 1, 2020. Crossref
-
Born J., Späth-Schwalbe E., The role of interferon-alpha in the regulation of sleep, in Psychiatry, Psychoimmunology, and Viruses, 1999. Crossref
-
Miklavčič D., Vodovnik L., Kotnik T., Possible Effects of Electromagnetic Fields on the Nervous — Endocrine — Immune Interactions, in Radio Frequency Radiation Dosimetry and Its Relationship to the Biological Effects of Electromagnetic Fields, 2000. Crossref
-
Larson Susan J., Behavioral and Motivational Effects of Immune-System Activation, The Journal of General Psychology, 129, 4, 2002. Crossref
-
Clement H. W., Buschmann J., Rex S., Grote C., Opper C., Gemsa D., Wesemann W., Effects of interferon-?, interleukin-1?, and tumor necrosis factor-? on the serotonin metabolism in the nucleus raphe dorsalis of the rat, Journal of Neural Transmission, 104, 10, 1997. Crossref
-
Bourjeily Ghada, Mohsenin Vahid, Sleep Physiology in Pregnancy, in Pulmonary Problems in Pregnancy, 2009. Crossref
-
Yirmiya Raz, Weidenfeld Joseph, Pollak Yehuda, Morag Michal, Morag Avraham, Avitsur Ronit, Barak Ohr, Reichenberg Avraham, Cohen Edna, Shavit Yehuda, Ovadia Haim, Cytokines, “Depression Due to A General Medical Condition,” and Antidepressant Drugs, in Cytokines, Stress, and Depression, 461, 1999. Crossref
-
Dunn A. J., Effects of the Immune System on Brain Neurochemistry, in Handbook of Neurochemistry and Molecular Neurobiology, 2008. Crossref
-
Chen Zutang, Krueger James M., Sleep Regulatory Substances: Change in mRNA Expression Linked to Sleep, in Molecular Regulation of Arousal States, 2019. Crossref
-
Kronfol Ziad, Cytokine Regulation in Major Depression, in Cytokines and Mental Health, 7, 2003. Crossref
-
Wood Lisa J., Nail Lillian M., Gilster April, Winters Kerri A., Elsea Collin R., Cancer Chemotherapy-Related Symptoms: Evidence to Suggest a Role for Proinflammatory Cytokines, Oncology Nursing Forum, 33, 3, 2006. Crossref
-
Krueger James M., Cytokine Involvement in Sleep Responses to Infection and Physiological Sleep, in Cytokines in the Nervous System, 1996. Crossref
-
Little Ryan E., Alt Jeremiah A., Ramakrishnan Vijay R., Platt Michael P., Schlosser Rodney J., Storck Kristina A., Soler Zachary M., Objective sleep measures after endoscopic sinus surgery in patients with chronic rhinosinusitis, International Forum of Allergy & Rhinology, 11, 7, 2021. Crossref
-
Arai Ken, Matsuki Norio, Ikegaya Yuji, Nishiyama Nobuyoshi, Deterioration of Spatial Learning Performances in Lipopolysaccharide-Treated Mice, Japanese Journal of Pharmacology, 87, 3, 2001. Crossref
-
Szentirmai Éva, Massie Ashley R., Kapás Levente, Lipoteichoic acid, a cell wall component of Gram-positive bacteria, induces sleep and fever and suppresses feeding, Brain, Behavior, and Immunity, 92, 2021. Crossref
-
Betancourt-Alonso Miguel Angel, Orihuela Agustín, Aguirre Virginio, Vázquez Reyes, Flores-Pérez Fernando Iván, Changes in behavioural and physiological parameters associated with Taenia pisiformis infection in rabbits (Oryctolagus cuniculus) that may improve early detection of sick rabbits, World Rabbit Science, 19, 1, 2011. Crossref
-
Alcohol, in Alcohol, 2021. Crossref
-
Dunn Adrian J., Researching the mechanisms underlying the symptoms of patients with cancer, in Cancer Symptom Science, 2010. Crossref
-
Fuchs Perry N., Boyette-Davis Jessica A., Dunn Adrian J., Cognitive impairment: basic science, in Cancer Symptom Science, 2010. Crossref
-
Yamamura S, Morishima H, Kumano-go T, Suganuma N, Matsumoto H, Adachi H, Sigedo Y, Mikami A, Kai T, Masuyama A, Takano T, Sugita Y, Takeda M, The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects, European Journal of Clinical Nutrition, 63, 1, 2009. Crossref
-
Parker Kathy P., Bliwise Donald L., Ribeiro Maria, Jain Sanjay R., Vena Catherine I., Kohles-Baker Mary Kay, Rogatko Andre, Xu Zhiheng, Harris Wayne B., Sleep/Wake Patterns of Individuals With Advanced Cancer Measured by Ambulatory Polysomnography, Journal of Clinical Oncology, 26, 15, 2008. Crossref
-
Ram Arjun, Pandey Haushila P, Matsumura Hitoshi, Kasahara-Orita Keiko, Nakajima Tomoko, Takahata Ryuichi, Satoh Shinsuke, Terao Akira, Hayaishi Osamu, CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats, Brain Research, 751, 1, 1997. Crossref
-
Satoh Shinsuke, Matsumura Hitoshi, Hayaishi Osamu, Involvement of adenosine A2A receptor in sleep promotion, European Journal of Pharmacology, 351, 2, 1998. Crossref
-
Lassmann Łukasz, Pollis Matteo, Żółtowska Agata, Manfredini Daniele, Gut Bless Your Pain—Roles of the Gut Microbiota, Sleep, and Melatonin in Chronic Orofacial Pain and Depression, Biomedicines, 10, 7, 2022. Crossref
-
Imeri Luca, Opp Mark R., How (and why) the immune system makes us sleep, Nature Reviews Neuroscience, 10, 3, 2009. Crossref
-
Parkar Shanthi G., Blum Daniel J., Microbiota as a Regulator of Circadian Rhythms—Special Focus on Sleep and Metabolism, in Comprehensive Gut Microbiota, 2022. Crossref
-
Nemoto Tsuyoshi, Irukayama‐Tomobe Yoko, Hirose Yuki, Tanaka Hiromu, Takahashi Genki, Takahashi Satoshi, Yanagisawa Masashi, Kanbayashi Takashi, Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide, Journal of Sleep Research, 2022. Crossref
-
MARTIN RICHARD J., BANKS-SCHLEGEL SUSAN, Chronobiology of Asthma, American Journal of Respiratory and Critical Care Medicine, 158, 3, 1998. Crossref
-
COHEN NICHOLAS, KINNEY KEVIN S., PROLOGUE: Exploring the Phylogenetic History of Neural-immune System Interactions: An Update, in Psychoneuroimmunology, 2007. Crossref
-
Irwin Michael R., Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature, Temperature, 2022. Crossref
-
Meusel Tiffany R., Kehoe Kelly E., Imani Farhad, Protein Kinase R Regulates Double-Stranded RNA Induction of TNF-α But Not IL-1β mRNA in Human Epithelial Cells, The Journal of Immunology, 168, 12, 2002. Crossref