Publicado 6 números por año
ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X
Indexed in
Microparticles and Nanoparticles as Delivery Systems for DNA Vaccines
SINOPSIS
DNA vaccines, also referred to as genetic vaccines, are generating significant preclinical and clinical interest. It has been proven that the expression of an antigen or antigens from plasmid DNA (pDNA) may elicit both humoral and cellular immune responses. Therefore, DNA vaccines may have potential as new vaccines for important pathogens such as HIV, hepatitis C, tuberculosis, and malaria. However, the clinical results using "naked" pDNA have been disappointing in the breadth and depth of the immune response and the relatively high doses of pDNA needed to elicit a response. Clinical trials with the gene gun have been promising, but it is unclear whether this technology will be commercially viable. As a result, there exists a clear need for new vaccine delivery systems that can be administered at low doses to elicit strong humoral and cellular immune responses. One promising approach is the development of microparticles and nanoparticles as delivery systems for DNA vaccines. In this review, the application of microparticles and nanoparticles as DNA vaccine delivery systems will be critically reviewed with a primary focus on those systems that have generated in vivo immune responses.
-
Voltan Rebecca, Castaldello Arianna, Brocca-Cofano Egidio, Altavilla Giuseppe, Caputo Antonella, Laus Michele, Sparnacci Katia, Ensoli Barbara, Spaccasassi Silvia, Ballestri Marco, Tondelli Luisa, Preparation and Characterization of Innovative Protein-coated Poly(Methylmethacrylate) Core-shell Nanoparticles for Vaccine Purposes, Pharmaceutical Research, 24, 10, 2007. Crossref
-
Epple M., Ganesan K., Heumann R., Klesing J., Kovtun A., Neumann S., Sokolova V., Application of calcium phosphatenanoparticles in biomedicine, J. Mater. Chem., 20, 1, 2010. Crossref
-
Tang Choon K., Lodding Jodie, Minigo Gabriela, Pouniotis Dodie S., Plebanski Magdalena, Scholzen Anja, McKenzie Ian F. C., Pietersz Geoffrey A., Apostolopoulos Vasso, Mannan-mediated gene delivery for cancer immunotherapy, Immunology, 120, 3, 2007. Crossref
-
Katz Eugenii, Willner Itamar, Integrierte Hybridsysteme aus Nanopartikeln und Biomolekülen: Synthese, Eigenschaften und Anwendungen, Angewandte Chemie, 116, 45, 2004. Crossref
-
Grichko Varvara, Grishko Victor, Shenderova Olga, Nanodiamond bullets and their biological targets, NanoBiotechnology, 2, 1-2, 2006. Crossref
-
Paolino Donatella, Sinha Piyush, Fresta Massimo, Ferrari Mauro, Drug Delivery Systems, in Encyclopedia of Medical Devices and Instrumentation, 2006. Crossref
-
Mena María, Chanfreau Sébastien, Gimeno Miquel, Bárzana Eduardo, Enzymatic synthesis of poly-l-lactide-co-glycolide in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate, Bioprocess and Biosystems Engineering, 33, 9, 2010. Crossref
-
Messai Isabelle, Delair Thierry, One-Step Cationic Poly(D,L-lactic acid) Particle Synthesis by Diafiltration and Interactions with Plasmid DNA, Macromolecular Materials and Engineering, 290, 8, 2005. Crossref
-
Bro�� Pavel, Hunziker Patrick, Nanotechnologies for Targeted Delivery of Drugs, in Nanotechnologies for the Life Sciences, 2007. Crossref
-
Katz Eugenii, Willner Itamar, Integrated Nanoparticle-Biomolecule Hybrid Systems: Synthesis, Properties, and Applications, Angewandte Chemie International Edition, 43, 45, 2004. Crossref
-
Wendorf Janet, Singh Manmohan, Chesko James, Kazzaz Jina, Soewanan Elawati, Ugozzoli Mildred, O'Hagan Derek, A Practical Approach to the use of Nanoparticles for Vaccine Delivery, Journal of Pharmaceutical Sciences, 95, 12, 2006. Crossref
-
Badea Ildiko, Verrall Ronald, Baca-Estrada Maria, Tikoo Suresh, Rosenberg Alan, Kumar Praveen, Foldvari Marianna, In vivo cutaneous interferon-γ gene delivery using novel dicationic (gemini) surfactant-plasmid complexes, The Journal of Gene Medicine, 7, 9, 2005. Crossref
-
Xie Zhao, Li Hui, Chen Jianlin, Zhang Hua-bing, Wang Ying-Yu, Chen Qian, Zhao Zhong-Zhong, Cheng Chi, Zhang Huan, Yang Yi, Wang Hong-Ning, Gao Rong, Shuffling of pig interleukin-2 gene and its enhancing of immunity in mice to Pasteurella multocida vaccine, Vaccine, 25, 48, 2007. Crossref
-
Maitra Amarnath, Calcium phosphate nanoparticles: second-generation nonviral vectors in gene therapy, Expert Review of Molecular Diagnostics, 5, 6, 2005. Crossref
-
Klausner Eytan A., Peer Dan, Chapman Robert L., Multack Richard F., Andurkar Shridhar V., Corneal gene therapy, Journal of Controlled Release, 124, 3, 2007. Crossref
-
Messai Isabelle, Lamalle Delphine, Munier Séverine, Verrier Bernard, Ataman-Önal Yasemin, Delair Thierry, Poly(d,l-lactic acid) and chitosan complexes: interactions with plasmid DNA, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 255, 1-3, 2005. Crossref
-
Bisht Savita, Bhakta Gajadhar, Mitra Susmita, Maitra Amarnath, pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery, International Journal of Pharmaceutics, 288, 1, 2005. Crossref
-
Jain Anekant, Yan Weili, Miller Keith R., O’Carra Ronan, Woodward Jerold G., Mumper Russell J., Tresyl-based conjugation of protein antigen to lipid nanoparticles increases antigen immunogenicity, International Journal of Pharmaceutics, 401, 1-2, 2010. Crossref
-
Sahoo S.K., Parveen S., Panda J.J., The present and future of nanotechnology in human health care, Nanomedicine: Nanotechnology, Biology and Medicine, 3, 1, 2007. Crossref
-
Tian Huayu, Tang Zhaohui, Zhuang Xiuli, Chen Xuesi, Jing Xiabin, Biodegradable synthetic polymers: Preparation, functionalization and biomedical application, Progress in Polymer Science, 37, 2, 2012. Crossref
-
Salman Hesham H., Gamazo Carlos, Campanero Miguel A., Irache Juan M., Salmonella-like bioadhesive nanoparticles, Journal of Controlled Release, 106, 1-2, 2005. Crossref
-
Singh Manmohan, Chakrapani Aravind, O’Hagan Derek, Nanoparticles and microparticles as vaccine-delivery systems, Expert Review of Vaccines, 6, 5, 2007. Crossref
-
Li Xinran, Sloat Brian R., Yanasarn Nijaporn, Cui Zhengrong, Relationship between the size of nanoparticles and their adjuvant activity: Data from a study with an improved experimental design, European Journal of Pharmaceutics and Biopharmaceutics, 78, 1, 2011. Crossref
-
Smitha S., Mukundan P., Krishna Pillai P., Warrier K.G.K., Silica–gelatin bio-hybrid and transparent nano-coatings through sol–gel technique, Materials Chemistry and Physics, 103, 2-3, 2007. Crossref
-
Fuller Deborah H., Loudon Peter, Schmaljohn Connie, Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases, Methods, 40, 1, 2006. Crossref
-
Sinyakov Michael S., Dror Moti, Lublin-Tennenbaum Tammy, Salzberg Samuel, Margel Shlomo, Avtalion Ramy R., Nano- and microparticles as adjuvants in vaccine design: Success and failure is related to host natural antibodies, Vaccine, 24, 42-43, 2006. Crossref
-
Munier Séverine, Messai Isabelle, Delair Thierry, Verrier Bernard, Ataman-Önal Yasemin, Cationic PLA nanoparticles for DNA delivery: Comparison of three surface polycations for DNA binding, protection and transfection properties, Colloids and Surfaces B: Biointerfaces, 43, 3-4, 2005. Crossref
-
Jo Jun-ichiro, Tabata Yasuhiko, Non-viral gene transfection technologies for genetic engineering of stem cells, European Journal of Pharmaceutics and Biopharmaceutics, 68, 1, 2008. Crossref
-
Greenland John R., Letvin Norman L., Chemical adjuvants for plasmid DNA vaccines, Vaccine, 25, 19, 2007. Crossref
-
Matic S., Minafra A., Boscia D., da Cunha A.T.P., Martelli G.P., Production of antibodies to Little cherry virus 1 coat protein by DNA prime and protein boost immunization, Journal of Virological Methods, 155, 1, 2009. Crossref
-
Poulsen Allan K., Arleth Lise, Almdal Kristoffer, Scharff-Poulsen Anne Marie, Unusually large acrylamide induced effect on the droplet size in AOT/Brij30 water-in-oil microemulsions, Journal of Colloid and Interface Science, 306, 1, 2007. Crossref
-
Zhang Hua-Bing, Wan Xiao-Ping, Bai Guang-Ming, Gao Lin-Feng, Chen Chi, Zhang Huang, Lv Xue-Bing, Wang Ze-Zhou, Li Jiang-Ling, Gao Rong, Improvement Of The Immunity Of Piglets To PRRS Vaccine By A Porcine IL-4 And IL-6 Fusion Gene Encapsulated In Chitosan Nanoparticles, Procedia in Vaccinology, 6, 2012. Crossref
-
Zheng Ying, Kovacs Jeffrey R., Gawalt Ellen S., Shen Hongmei, Meng Wilson S., Characterization of particles fabricated with poly(D,L-lactic-co-glycolic acid) and an ornithine–histidine peptide as carriers of oligodeoxynucleotide for delivery into primary dendritic cells, Journal of Biomaterials Science, Polymer Edition, 17, 12, 2006. Crossref
-
DENKBAŞ EMIR B., VASEASHTA A., NANOTECHNOLOGY IN MEDICINE AND HEALTH SCIENCES, Nano, 03, 04, 2008. Crossref
-
Tafalla Carolina, Bøgwald Jarl, Dalmo Roy A., Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives, Fish & Shellfish Immunology, 35, 6, 2013. Crossref
-
Wu Qinge, Du Fang, Luo Yu, Lu Wei, Huang Jin, Yu Jiahui, Liu Shiyuan, Poly(ethylene glycol) shell-sheddable nanomicelle prodrug of camptothecin with enhanced cellular uptake, Colloids and Surfaces B: Biointerfaces, 105, 2013. Crossref
-
Tafalla Carolina, Bøgwald Jarl, Dalmo Roy A., Munang'andu Hetron Mweemba, Evensen Øystein, Adjuvants in Fish Vaccines, in Fish Vaccination, 2014. Crossref
-
He Pan, Takeshima Shin-nosuke, Tada Seiichi, Akaike Toshihiro, Ito Yoshihiro, Aida Yoko, pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity, Vaccine, 32, 47, 2014. Crossref
-
Lanao José M., Briones Elsa, Colino Clara I., Recent advances in delivery systems for anti-HIV1 therapy, Journal of Drug Targeting, 15, 1, 2007. Crossref
-
Lala Sanchaita, Pramanick Swapan, Mukhopadhyay Sibabrata, Bandyopadhyay Santu, Basu Mukul Kumar, Harmine: Evaluation of its Antileishmanial Properties in Various Vesicular Delivery Systems, Journal of Drug Targeting, 12, 3, 2004. Crossref
-
Lala Sanchaita, Gupta Syamasri, Sahu Niranjan P., Mandal Debayan, Mondal Nirup B., Moulik Satya P., Basu Mukul K., Critical evaluation of the therapeutic potential of bassic acid incorporated in oil-in-water microemulsions and poly-d,l-lactide nanoparticles against experimental leishmaniasis, Journal of Drug Targeting, 14, 4, 2006. Crossref
-
Literature Alerts, Journal of Microencapsulation, 21, 3, 2004. Crossref
-
Tiptiri-Kourpeti Angeliki, Spyridopoulou Katerina, Pappa Aglaia, Chlichlia Katerina, DNA vaccines to attack cancer: Strategies for improving immunogenicity and efficacy, Pharmacology & Therapeutics, 165, 2016. Crossref
-
Poecheim Johanna, Barnier-Quer Christophe, Collin Nicolas, Borchard Gerrit, Ag85A DNA Vaccine Delivery by Nanoparticles: Influence of the Formulation Characteristics on Immune Responses, Vaccines, 4, 3, 2016. Crossref
-
Dalmo Roy, Bøgwald Jarl, Tafalla Carolina, Adjuvants and Delivery Methods: Current and Novel, in Fish Vaccines, 2016. Crossref
-
Kaul Goldie, Amiji Mansoor, Biodistribution and Targeting Potential of Poly(ethylene glycol)-modified Gelatin Nanoparticles in Subcutaneous Murine Tumor Model, Journal of Drug Targeting, 12, 9-10, 2004. Crossref
-
Shan Songhua, Fenwick Stan, Ellis Trevor, Poinern Eddy, Edwards John, Le Xuan, Jiang Zhongtao, Evaluation of different chemical adjuvants on an avian influenza H6 DNA vaccine in chickens, Avian Pathology, 45, 6, 2016. Crossref
-
Xu Menglu, Chen Yulin, Banerjee Parikshit, Zong Li, Jiang Lei, Dendritic Cells Targeting and pH-Responsive Multi-layered Nanocomplexes for Smart Delivery of DNA Vaccines, AAPS PharmSciTech, 18, 7, 2017. Crossref
-
Kumar Amit, Xu Yuehong, Cui Zhengrong, Cutaneous DNA Immunization: Enhancing Penetration by Hair Follicle Modification or Microneedle Application, in Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement, 2017. Crossref
-
Chen Yi, Song Tingyu, Xiao Yong-Le, Wan Xiaoping, Yang Luyi, Li Jinghai, Zeng Guangzhi, Fang Pengfei, Wang Ze-Zhou, Gao Rong, Enhancement of immune response of piglets to PCV-2 vaccine by porcine IL-2 and fusion IL-4/6 gene entrapped in chitosan nanoparticles, Research in Veterinary Science, 117, 2018. Crossref
-
Sahoo S. K., Parveen S., Panda J. J., Chapter 32: The Present and Future of Nanotechnology in Human Health Care, in Nanomedicine in Cancer, 2017. Crossref
-
Vincent Abhilash, Babu Suresh, Heckert Eric, Dowding Janet, Hirst Suzanne M., Inerbaev Talgat M., Self William T., Reilly Christopher M., Masunov Artëm E., Rahman Talat S., Seal Sudipta, Protonated Nanoparticle Surface Governing Ligand Tethering and Cellular Targeting, ACS Nano, 3, 5, 2009. Crossref
-
Moghimi S. Moein, Hunter A. Christy, Murray J. Clifford, Nanomedicine: current status and future prospects, The FASEB Journal, 19, 3, 2005. Crossref
-
Bassi Matteo, Santinello Irene, Bevilacqua Andrea, Bassi Pierfrancesco, Nanotechnology: A Big Revolution from the Small World, Urologia Journal, 80, 1, 2013. Crossref
-
Vaseashta A., Nanoscale Materials, Devices, and Systems for Chem.-Bio Sensors, Photonics, and Energy Generation and Storage, in Functionalized Nanoscale Materials, Devices and Systems, 2008. Crossref
-
Goyal Amit K., Rath Goutam, Garg Tarun, Nanotechnological Approaches for Genetic Immunization, in DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases, 2013. Crossref
-
Mazda Osam, Kishida Tsunao, Functional Nucleotide Sequences Capable of Promoting Non-viral Genetic Transfer, in Non-viral Gene Therapy, 2005. Crossref
-
Perera Glen, Bernkop-Schnürch Andreas, Pharmaceutical Non-Viral Formulations for Gene Vaccines, in Gene Vaccines, 2012. Crossref
-
Manthorpe Marston, Hobart Peter, Hermanson Gary, Ferrari Marilyn, Geall Andrew, Goff Blake, Rolland Alain, Plasmid Vaccines and Therapeutics: From Design to Applications, in Gene Therapy and Gene Delivery Systems, 99, 2005. Crossref
-
Kaminski Robert W., Turbyfill K. Ross, Chao C., Ching W. M., Oaks Edwin V., Mucosal Adjuvanticity of a Shigella Invasin Complex with DNA-Based Vaccines , Clinical and Vaccine Immunology, 16, 4, 2009. Crossref
-
Chacon O., Bannantine J.P., DNA Vaccines Against Tuberculosis, in Mycobacterium Bovis Infection in Animals and Humans, 2006. Crossref
-
Hazarika Hemanga, Krishnatreyya Harshita, Chattopadhyay Pronobesh, Saha Achintya, Pathak Yashwant V., Zaman Md Kamaruz, Nanoemulsion Delivery of Herbal Products: Prospects and Challenges, in Nano Medicine and Nano Safety, 2020. Crossref
-
Olsen Hannah E, Lynn Geoffrey M, Valdes Pablo A, Cerecedo Lopez Christian D, Ishizuka Andrew S, Arnaout Omar, Bi W Linda, Peruzzi Pier Paolo, Chiocca E Antonio, Friedman Gregory K, Bernstock Joshua D, Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies, Neuro-Oncology Advances, 3, 1, 2021. Crossref
-
Chen Liben, Li Shuang, Wang Zhengfang, Chang Ruilong, Su Jingliang, Han Bo, Protective effect of recombinant staphylococcal enterotoxin A entrapped in polylactic-co-glycolic acid microspheres against Staphylococcus aureus infection, Veterinary Research, 43, 1, 2012. Crossref
-
de Souza J Brian, Immunization of experimental animals, in eLS, 2006. Crossref
-
Schmidt Hartley T., Gray Ben L., Wingert Philip A., Ostafin Agnes E., Assembly of Aqueous-Cored Calcium Phosphate Nanoparticles for Drug Delivery, Chemistry of Materials, 16, 24, 2004. Crossref
-
Pinheiro Marina, Lúcio Marlene, Lima José LFC, Reis Salette, Liposomes as drug delivery systems for the treatment of TB, Nanomedicine, 6, 8, 2011. Crossref
-
Liang Yan, Cui Lei, Xiao Li, Liu Xiao, Yang Yourong, Ling Yanbo, Wang Tong, Wang Lan, Wang Jie, Wu Xueqiong, Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation, Frontiers in Immunology, 13, 2022. Crossref
-
Gelinas David S., DaSilva Kevin, Fenili Daniela, St. George-Hyslop Peter, McLaurin JoAnne, Immunotherapy for Alzheimer's disease, Proceedings of the National Academy of Sciences, 101, suppl_2, 2004. Crossref
-
Winstone Nicola, Wilson Aaron J., Morrow Gavin, Boggiano Cesar, Chiuchiolo Maria J., Lopez Mary, Kemelman Marina, Ginsberg Arielle A., Mullen Karl, Coleman John W., Wu Chih-Da, Narpala Sandeep, Ouellette Ian, Dean Hansi J., Lin Feng, Sardesai Niranjan Y., Cassamasa Holly, McBride Dawn, Felber Barbara K., Pavlakis George N., Schultz Alan, Hudgens Michael G., King C. Richter, Zamb Timothy J., Parks Christopher L., McDermott Adrian B., Enhanced Control of Pathogenic Simian Immunodeficiency Virus SIVmac239 Replication in Macaques Immunized with an Interleukin-12 Plasmid and a DNA Prime-Viral Vector Boost Vaccine Regimen, Journal of Virology, 85, 18, 2011. Crossref
-
Yu Jiahui, Li Xiangyang, Luo Yu, Lu Wei, Huang Jin, Liu Shiyuan, Poly(ethylene glycol) shell-sheddable magnetic nanomicelle as the carrier of doxorubicin with enhanced cellular uptake, Colloids and Surfaces B: Biointerfaces, 107, 2013. Crossref