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Critical Reviews™ in Therapeutic Drug Carrier Systems

Publicado 6 números por año

ISSN Imprimir: 0743-4863

ISSN En Línea: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Targeting of Peptide and Protein Drugs to Specific Sites in the Oral Route

Volumen 12, Edición 4, 1995, pp. 339-371
DOI: 10.1615/CritRevTherDrugCarrierSyst.v12.i4.30
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SINOPSIS

Although the distal small intestine has less lumenal and apical proteolytic activities, it has high activities of some apical peptidases. Colonic proteolytic activities are substantial, but their nature is less understood. The small intestine has di- and tripeptide transporter, facilitating absorption, and P-glycoprotein, an efflux pump suggested to limit absorption of small peptides. Several peptide and nonpeptide drugs have higher absorption in the ileum; however, enhancement on their absorption by enhancers varies from site to site. Specific delivery systems can target drugs to the distal intestine utilizing distinct regional pHs and specific microbial enzymes, but the key is how to achieve a reliable release.

CITADO POR
  1. Leone-Bay Andrea, Paton Duncan R., Weidner John J., The Development of Delivery Agents that Facilitate the Oral Absorption of Macromolecular Drugs, Medicinal Research Reviews, 20, 2, 2000. Crossref

  2. Zhang Xiaoyi, Wang Wei, Cheng Shenling, Zhao Ming, Zheng Meiqing, Chang Heng Wei, Wu Jianhui, Peng Shiqi, 2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity, Bioorganic & Medicinal Chemistry, 18, 4, 2010. Crossref

  3. Walker J.R., Altman E., Roth J.R., Anin vivostudy of novel bioactive peptides that inhibit the growth ofEscherichia coli, The Journal of Peptide Research, 58, 5, 2001. Crossref

  4. Sutar Prashant B., Mishra Rakesh K., Pal Kunal, Banthia Ajit K., Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system, Journal of Materials Science: Materials in Medicine, 19, 6, 2008. Crossref

  5. Lee Hye J., Protein drug oral delivery: The recent progress, Archives of Pharmacal Research, 25, 5, 2002. Crossref

  6. Whateley Tony L., Literature Alerts, Drug Delivery, 3, 3, 1996. Crossref

  7. Krondahl Eva, Von Euler-Chelpin Hans, Orzechowski Achim, Ekström Gunilla, Lennernäs Hans, Investigations of the In-vitro Metabolism of Three Opioid Tetrapeptides by Pancreatic and Intestinal Enzymes, Journal of Pharmacy and Pharmacology, 52, 7, 2010. Crossref

  8. des Rieux Anne, Fievez Virginie, Garinot Marie, Schneider Yves-Jacques, Préat Véronique, Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach, Journal of Controlled Release, 116, 1, 2006. Crossref

  9. Sadeghi A.M.M., Avadi M.R., Ejtemaimehr Sh., Abashzadeh Sh., Partoazar A., Dorkoosh F., Faghihi M., Rafiee-Tehrani M., Junginger H.E., Development of a Gas Empowered Drug Delivery system for peptide delivery in the small intestine, Journal of Controlled Release, 134, 1, 2009. Crossref

  10. Dorkoosh Farid A, Verhoef J.C, Borchard G, Rafiee-Tehrani M, Junginger Hans E, Development and characterization of a novel peroral peptide drug delivery system, Journal of Controlled Release, 71, 3, 2001. Crossref

  11. Thanou M.M, Kotzé A.F, Scharringhausen T, Lueßen H.L, de Boer A.G, Verhoef J.C, Junginger H.E, Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers, Journal of Controlled Release, 64, 1-3, 2000. Crossref

  12. Zhang Ying, Ruder Warren C., LeDuc Philip R., Artificial cells: building bioinspired systems using small-scale biology, Trends in Biotechnology, 26, 1, 2008. Crossref

  13. Maroni Alessandra, Zema Lucia, Del Curto Maria Dorly, Foppoli Anastasia, Gazzaniga Andrea, Oral colon delivery of insulin with the aid of functional adjuvants, Advanced Drug Delivery Reviews, 64, 6, 2012. Crossref

  14. Moridani Majid Y., Reducing Presystemic Drug Metabolism, in Prodrugs and Targeted Delivery, 2011. Crossref

  15. Kim Heejung, Kim Duksoo, Choi Daekyu, Jeon Hyunchu, Han Jungoh, Jung Yunjin, Kong Hyesik, Kim Young Mi, Synthesis and Properties ofN,N′-Bis(5-Aminosalicyl)-L-Cystine as a Colon-Specific Deliverer of 5-Aminosalicylic Acid and Cystine, Drug Delivery, 15, 1, 2008. Crossref

  16. Cheng Shenling, Zhang Xiaoyi, Wang Wei, Zhao Ming, Zheng Meiqing, Chang Heng Wei, Wu Jianghui, Peng Shiqi, A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-l-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis, European Journal of Medicinal Chemistry, 44, 12, 2009. Crossref

  17. Dorkoosh Farid A., Coos Verhoef J., Ambagts Matheus H.C., Rafiee-Tehrani Morteza, Borchard Gerrit, Junginger Hans E., Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin, octreotide and insulin, European Journal of Pharmaceutical Sciences, 15, 5, 2002. Crossref

  18. Fagerholm Urban, Sjöström Brita, Sroka-Markovic Janina, Wijk Annika, Svensson Marianne, Lennernäs Hans, The Effect of a Drug-delivery System Consisting of Soybean Phosphatidyl Choline and Medium-chain Monoacylglycerol on the Intestinal Permeability of Hexarelin in the Rat, Journal of Pharmacy and Pharmacology, 50, 5, 2011. Crossref

  19. Quan Ying-Shu, Fujita Takuya, Tohara Daichi, Tsuji Miwako, Kohyama Makoto, Yamamoto Akira, Transport kinetics of leucine enkephalin across Caco-2 monolayers: Quantitative analysis for contribution of enzymatic and transport barrier, Life Sciences, 64, 14, 1999. Crossref

  20. Jian Hong Lei, Zhu Li Wei, Zhang Wei Ming, Qi Xiang, Jiang Jian Xin, Evaluation of Galactomannan from <i>Gleditsia Sinensis</i> Lam. as Sustained Release Material in Colonic Drug Delivery, Advanced Materials Research, 146-147, 2010. Crossref

  21. Walker Jennifer R., Warren James, Altman Elliot, An intracellular approach for generating stable synthetic peptides and its potential applications, in Peptides for the New Millennium, 6, 2002. Crossref

  22. Hirayama Fumitoshi, Uekama Kaneto, Colonic Delivery, in Prodrugs, V, 2007. Crossref

  23. Walker J. R., Altman R. K., Warren J. W., Altman E., Using protein-based motifs to stabilize peptides, The Journal of Peptide Research, 62, 5, 2003. Crossref

  24. Trofimova Svetlana V., Khavinson Vladimir Kh., Role of Short Peptides as an Important Nutritional Element in Maintenance of Body Homeostasis, in Nutrition, Food and Diet in Ageing and Longevity, 14, 2021. Crossref

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