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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Mechanisms of Yin Yang 1 in Oncogenesis: The Importance of Indirect Effects

Volumen 16, Edición 3-4, 2011, pp. 143-161
DOI: 10.1615/CritRevOncog.v16.i3-4.20
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SINOPSIS

Yin Yang 1 (YY1) is a ubiquitously expressed transcription factor that performs numerous functions including transcriptional regulation, cell growth control, apoptosis, large-scale chromosomal dynamics, and X-chromosome inactivation. YY1 clearly is able to control cell functions, including proliferation, by acting as a transcription factor either to activate or repress specific genes. Based on its ability to regulate cell growth control genes, it has been argued that YY1 can function as an oncogene that initiates oncogenesis. Although this is an attractive hypothesis, no reports indicate that YY1 can acutely transform cells in culture or form tumors within animals when overexpressed. Thus, it remains unclear whether YY1 is a "classic" oncogene. However, YY1 controls many diverse cell functions, and these functions may provide clues to its role in oncogenesis. We propose that in many cases YY1 may function in oncogenesis and disease progression through "indirect" effects by virtue of its role in either recruiting Polycomb group proteins to DNA, regulating mutator protein accumulation, controlling large-scale chromosomal dynamics or genomic integrity. Disruption of these functions may causally initiate cancer or may contribute to disease progression. Targeting YY1 functions provides possible avenues for clinical intervention.

CITADO POR
  1. Luo Judong, Zhou Xifa, Ge Xin, Liu Pengfei, Cao Jianping, Lu Xujing, Ling Yang, Zhang Shuyu, Upregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1, Cancer Science, 104, 11, 2013. Crossref

  2. Panagopoulos Ioannis, Thorsen Jim, Gorunova Ludmila, Micci Francesca, Haugom Lisbeth, Davidson Ben, Heim Sverre, RNA sequencing identifies fusion of theEWSR1andYY1genes in mesothelioma with t(14;22)(q32;q12), Genes, Chromosomes and Cancer, 52, 8, 2013. Crossref

  3. Yan XiaoHua, Pan Jun, Xiong WanWan, Cheng MinZhang, Sun YingYuan, Zhang SuPing, Chen YeGuang, Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus, Science China Life Sciences, 57, 1, 2014. Crossref

  4. Schlesinger Sharon, Lee Andreia H., Wang Gary Z., Green Lisa, Goff Stephen P., Proviral Silencing in Embryonic Cells Is Regulated by Yin Yang 1, Cell Reports, 4, 1, 2013. Crossref

  5. Arvey Aaron, Tempera Italo, Lieberman Paul, Interpreting the Epstein-Barr Virus (EBV) Epigenome Using High-Throughput Data, Viruses, 5, 4, 2013. Crossref

  6. Bonavida Benjamin, Kaufhold Samantha, Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target, Pharmacology & Therapeutics, 150, 2015. Crossref

  7. Lin Jinpiao, He Yujue, Chen Junmin, Zeng Zhiyong, Yang Bin, Ou Qishui, A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6, Journal of Autoimmunity, 77, 2017. Crossref

  8. Li Jun, Woods Susan L., Healey Sue, Beesley Jonathan, Chen Xiaoqing, Lee Jason S., Sivakumaran Haran, Wayte Nicci, Nones Katia, Waterfall Joshua J., Pearson John, Patch Anne-Marie, Senz Janine, Ferreira Manuel A., Kaurah Pardeep, Mackenzie Robertson, Heravi-Moussavi Alireza, Hansford Samantha, Lannagan Tamsin R.M., Spurdle Amanda B., Simpson Peter T., da Silva Leonard, Lakhani Sunil R., Clouston Andrew D., Bettington Mark, Grimpen Florian, Busuttil Rita A., Di Costanzo Natasha, Boussioutas Alex, Jeanjean Marie, Chong George, Fabre Aurélie, Olschwang Sylviane, Faulkner Geoffrey J., Bellos Evangelos, Coin Lachlan, Rioux Kevin, Bathe Oliver F., Wen Xiaogang, Martin Hilary C., Neklason Deborah W., Davis Sean R., Walker Robert L., Calzone Kathleen A., Avital Itzhak, Heller Theo, Koh Christopher, Pineda Marbin, Rudloff Udo, Quezado Martha, Pichurin Pavel N., Hulick Peter J., Weissman Scott M., Newlin Anna, Rubinstein Wendy S., Sampson Jone E., Hamman Kelly, Goldgar David, Poplawski Nicola, Phillips Kerry, Schofield Lyn, Armstrong Jacqueline, Kiraly-Borri Cathy, Suthers Graeme K., Huntsman David G., Foulkes William D., Carneiro Fatima, Lindor Noralane M., Edwards Stacey L., French Juliet D., Waddell Nicola, Meltzer Paul S., Worthley Daniel L., Schrader Kasmintan A., Chenevix-Trench Georgia, Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant, The American Journal of Human Genetics, 98, 5, 2016. Crossref

  9. Wang Ya-fang, Zhang Jie, Su Yi, Shen Yan-yan, Jiang Dong-xian, Hou Ying-yong, Geng Mei-yu, Ding Jian, Chen Yi, G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin, Nature Communications, 8, 1, 2017. Crossref

  10. Zheng Liduan, Chen Yajun, Ye Lin, Jiao Wanju, Song Huajie, Mei Hong, Li Dan, Yang Feng, Li Huanhuan, Huang Kai, Tong Qiangsong, miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression, Scientific Reports, 7, 1, 2017. Crossref

  11. Huang Tonghai, Wang Guangsuo, Yang Lin, Peng Bin, Wen Yuxin, Ding Guanggui, Wang Zheng, MiR-186 inhibits proliferation, migration, and invasion of non-small cell lung cancer cells by downregulating Yin Yang 1, Cancer Biomarkers, 21, 1, 2017. Crossref

  12. Rhee Siyeon, Guerrero-Zayas Mara-Isel, Wallingford Mary C., Ortiz-Pineda Pablo, Mager Jesse, Tremblay Kimberly D., Oshima Robert, Visceral Endoderm Expression of Yin-Yang1 (YY1) Is Required for VEGFA Maintenance and Yolk Sac Development, PLoS ONE, 8, 3, 2013. Crossref

  13. Moorthi Sitapriya, Burns Tara Ann, Yu Gui‐Qin, Luberto Chiara, Bcr‐Abl regulation of sphingomyelin synthase 1 reveals a novel oncogenic‐driven mechanism of protein up‐regulation, The FASEB Journal, 32, 8, 2018. Crossref

  14. Wang Yali, Wu Shourong, Huang Can, Li Yanjun, Zhao Hezhao, Kasim Vivi, Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3, Cancer Science, 109, 8, 2018. Crossref

  15. Daraiseh Susan I., Kassardjian Ari, Alexander Karen E., Rizkallah Raed, Hurt Myra M., c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865, 9, 2018. Crossref

  16. Parekh Vaishali I, Modali Sita D, Welch James, Simonds William F, Weinstein Lee S, Kebebew Electron, Agarwal Sunita K, Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas, Endocrine-Related Cancer, 25, 5, 2018. Crossref

  17. Ji Decai, Jiang Lining, Li Yingjie, MiR-192-5p suppresses the growth of bladder cancer cells via targeting Yin Yang 1, Human Cell, 31, 3, 2018. Crossref

  18. Gao Dan, Wang Lingling, Zhang Hua, Yan Xiaojie, Yang Jie, Zhou Ruimin, Chang Xinzhong, Sun Yanan, Tian Shanshan, Yao Zhi, Zhang Kai, Liu Zhe, Ma Zhenyi, Spleen tyrosine kinase SYK (L) interacts with YY 1 and coordinately suppresses SNAI 2 transcription in lung cancer cells , The FEBS Journal, 285, 22, 2018. Crossref

  19. Zhao Lu, Li Ran, Gan Ye-Hua, Knockdown of Yin Yang 1 enhances anticancer effects of cisplatin through protein phosphatase 2A-mediated T308 dephosphorylation of AKT, Cell Death & Disease, 9, 7, 2018. Crossref

  20. Figiel Małgorzata, Łakomska Julia, Miłek Piotr, Dziedzicka‐Wasylewska Marta, Górecki Andrzej, The transcription factor YY 2 has less momentous properties of an intrinsically disordered protein than its paralog YY 1 , FEBS Letters, 593, 14, 2019. Crossref

  21. Sarvagalla Sailu, Kolapalli Srinivasa Prasad, Vallabhapurapu Sivakumar, The Two Sides of YY1 in Cancer: A Friend and a Foe, Frontiers in Oncology, 9, 2019. Crossref

  22. Özenver Nadire, Efferth Thomas, Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  23. Kashfi Khosrow, Zhou Yongxin, Corrente Gabrielle M., RKIP a master of regulatory pathways: Perspectives, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  24. Wang An-Ming, Huang Tzu-Ting, Hsu Kai-Wen, Huang Kuo-Hung, Fang Wen-Liang, Yang Muh-Hwa, Lo Su-Shun, Chi Chin-Wen, Lin Jing-Jer, Yeh Tien-Shun, Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis, Oncotarget, 5, 13, 2014. Crossref

  25. Cheng Qingsu, Khoshdeli Mina, Ferguson Bradley S, Jabbari Kosar, Zang Chongzhi, Parvin Bahram, Murphy Robert, YY1 is a cis-regulator in the organoid models of high mammographic density, Bioinformatics, 36, 6, 2020. Crossref

  26. Kashyap Vaishali, Bonavida Benjamin, Role of YY1 in the pathogenesis of prostate cancer and correlation with bioinformatic data sets of gene expression, Genes & Cancer, 5, 3-4, 2014. Crossref

  27. Chen Qun, Wang Wu-Jun, Jia Yun-Xuan, Yuan Hao, Wu Peng-Fei, Ge Wan-Li, Meng Ling-Dong, Huang Xu-Min, Shen Peng, Yang Tao-Yue, Miao Yi, Zhang Jing-Jing, Jiang Kui-Rong, Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review, Cell & Bioscience, 11, 1, 2021. Crossref

  28. Navasardyan Inesa, Bonavida Benjamin, YY1 is involved in the pathogenesis and malignant properties of human triple-negative breast cancer (TNBC), in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  29. Lopez-Perez Tania V., Tirado-Rodriguez Belen, Morales-Martinez Mario, Montecillo-Aguado Mayra, Huerta-Yepez Sara, Yin Yang 1 regulation of tumor cell resistance to chemotherapeutic drugs, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  30. Li Yanjun, Meliala Ian Timothy Sembiring, Wei Mankun, Kasim Vivi, YY1 and tumor metastasis regulation, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  31. Zhou Shuai, Qu Kang Lin, Li Jin Ang, Chen Shi Lei, Zhang Yi Gang, Zhu Chao, Jin Hao, Wang Yong, Pang Qing, Liu Hui Chun, YY1 activates EMI2 and promotes the progression of cholangiocarcinoma through the PI3K/Akt signaling axis, Cancer Cell International, 21, 1, 2021. Crossref

  32. Wang Jianwei, Zhou Lina, Li Zhi, Zhang Ting, Liu Wenpeng, Liu Zheng, Yuan Yate-Ching, Su Fan, Xu Lu, Wang Yan, Zhou Xiaotong, Xu Hong, Hua Yuejin, Wang Ying-Jie, Zheng Li, Teng Yue-E, Shen Binghui, YY1 suppresses FEN1 over-expression and drug resistance in breast cancer, BMC Cancer, 15, 1, 2015. Crossref

  33. Pérez-Palacios Raquel, Climent María, Santiago-Arcos Javier, Macías-Redondo Sofía, Klar Martin, Muniesa Pedro, Schoorlemmer Jon, YY2 in Mouse Preimplantation Embryos and in Embryonic Stem Cells, Cells, 10, 5, 2021. Crossref

  34. Wu Shourong, Wang Huimin, Li Yanjun, Xie Yudan, Huang Can, Zhao Hezhao, Miyagishi Makoto, Kasim Vivi, Transcription Factor YY1 Promotes Cell Proliferation by Directly Activating the Pentose Phosphate Pathway, Cancer Research, 78, 16, 2018. Crossref

  35. Garcia‐Marques Fernando, Liu Shiqin, Totten Sarah M., Bermudez Abel, Tanimoto Cheylene, Hsu En‐Chi, Nolley Rosalie, Hembree Amy, Stoyanova Tanya, Brooks James D., Pitteri Sharon J., Protein signatures to distinguish aggressive from indolent prostate cancer, The Prostate, 82, 5, 2022. Crossref

  36. Kwiatkowska Dominika, Mazur Ewelina, Reich Adam, YY1 Is a Key Player in Melanoma Immunotherapy/Targeted Treatment Resistance, Frontiers in Oncology, 12, 2022. Crossref

  37. Zhang Yin-Ling, Cao Jin-Ling, Zhang Ye, Liao Li, Deng Ling, Yang Shao-Ying, Hu Shu-Yuan, Ning Yan, Zhang Fang-Lin, Li Da-Qiang, RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression, Medical Oncology, 39, 4, 2022. Crossref

  38. Yang Tingting, Hu Yinlu, Chen Shangxiu, Li Lin, Cao Xinyun, Yuan Jiayu, Shu Fanglin, Jiang Zhenzhou, Qian Sitong, Zhu Xia, Wei Chujing, Wei Rui, Yan Meng, Li Chenglin, Yin Xiaoxing, Lu Qian, YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis, Cell Biology and Toxicology, 2022. Crossref

  39. Warowicka Alicja, Broniarczyk Justyna, Węglewska Martyna, Kwaśniewski Wojciech, Goździcka-Józefiak Anna, Dual Role of YY1 in HPV Life Cycle and Cervical Cancer Development, International Journal of Molecular Sciences, 23, 7, 2022. Crossref

  40. Cherik Florian, Reilly Jack, Kerkhof Jennifer, Levy Michael, McConkey Haley, Barat-Houari Mouna, Butler Kameryn M., Coubes Christine, Lee Jennifer A., Le Guyader Gwenael, Louie Raymond J., Patterson Wesley G., Tedder Matthew L., Bak Mads, Hammer Trine Bjørg, Craigen William, Démurger Florence, Dubourg Christèle, Fradin Mélanie, Franciskovich Rachel, Frengen Eirik, Friedman Jennifer, Palares Nathalie Ruiz, Iascone Maria, Misceo Doriana, Monin Pauline, Odent Sylvie, Philippe Christophe, Rouxel Flavien, Saletti Veronica, Strømme Petter, Thulin Perla Cassayre, Sadikovic Bekim, Genevieve David, DNA methylation episignature in Gabriele-de Vries syndrome, Genetics in Medicine, 24, 4, 2022. Crossref

  41. Singh Archana, Gupta Aayush, Chowdhary Manish, Brahmbhatt Hemang D., Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermis, Experimental Dermatology, 30, 9, 2021. Crossref

  42. Abe Hajime, Ogawa Takashi, Wang Liyun, Kimura Masayuki, Tanaka Takeshi, Morita Reiko, Yoshida Toshinori, Shibutani Makoto, Promoter-region hypermethylation and expression downregulation of Yy1 (Yin yang 1) in preneoplastic liver lesions in a thioacetamide rat hepatocarcinogenesis model, Toxicology and Applied Pharmacology, 280, 3, 2014. Crossref

  43. Woo Caroline J., Kharchenko Peter V., Daheron Laurence, Park Peter J., Kingston Robert E., Variable Requirements for DNA-Binding Proteins at Polycomb-Dependent Repressive Regions in Human HOX Clusters, Molecular and Cellular Biology, 33, 16, 2013. Crossref

  44. Li Meng, Li Mingying, Xia Yuan, Li Guosheng, Su Xiuhua, Wang Dongmei, Ye Jingjing, Lu Fei, Sun Tao, Ji Chunyan, HDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation, Cell Death & Disease, 13, 11, 2022. Crossref

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