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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Retrodifferentiation and Cell Death

Volumen 5, Edición 4, 1994, pp. 359-371
DOI: 10.1615/CritRevOncog.v5.i4.20
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SINOPSIS

The reversibility of a differentiation program termed dedifferentiation, redifferentiation, or retrodifferentiation opens a spectrum of new possibilities for cellular development. During differentiation and retrodifferentiation, the expression of gene products associated with a differentiated phenotype and cell cycle regulation demonstrate inverse patterns. This effect requires a coordinated network that simultaneously controls cell growth and differentiation. In particular, crosstalk between induction of differentiation and G0/G1, cell cycle exit can be initiated and sustained by activated serine/threonine kinases and tyrosine kinases. Phosphorylation signals are relayed to certain genes or transcription factors such as Fos/Jun, EGR-1, NF-κB, MyoD, or the Myc/ Max gene family. However, the precise regulation of these transcription factors to confer signals to differentiation-associated and cell cycle-regulatory genes remains unclear. Cell cycle exit into a transient G0'-arrest cycle or a terminal G0 phase is determined by a network of phosphorylation signals involving the retinoblastoma protein and a variety of factors such as the E2F family, cyclins, and cyclin-dependent kinases. In this context, a variety of differentiation-induced cell lines, including monocytic, neuronal, or muscle cells, can progress through the G0'-arrest cycle, whereby a certain population retains the capacity to retrodifferentiate and reenter the cell cycle. In contrast, the rest of the differentiated population enters the irreversible G0 phase (terminal commitment) that finally results in programmed cell death. The expression of growth arrest-specific (gas and gadd) genes is associated with the G0'-arrest cycle, and other factors, including c-myc, p53, mdm2, and bcl2/bclx, contribute to the regulation of the cell death program. Although the precise signaling cascade determining retrodifferentiation or cell death remains unclear, a coordinated inter- and intracellular regulation could establish a certain biological balance between these exclusive pathways. Consequently, a retrodifferentiation process may provide a potential for cell type conversion or transdifferentiation, whereby retrodifferentiated cells can be induced to develop via a different pathway according to tissue-specific requirements.

CITADO POR
  1. Hass Ralf, Retrodifferentiation and reversibility of aging: forever young?, Signal Transduction, 5, 3, 2005. Crossref

  2. Ninomiya Youichirou, Adams Richard, Morriss-Kay Gillian M., Eto Kazuhiro, Apoptotic cell death in neuronal differentiation of P19 EC cells: Cell death follows reentry into S phase, Journal of Cellular Physiology, 172, 1, 1997. Crossref

  3. Heininger Kurt, The cerebral glucose-fatty acid cycle: Evolutionary roots, regulation, and (patho)physiological importance, in Glucose Metabolism in the Brain, 51, 2002. Crossref

  4. Vartanian Amalia, Prudovsky Igor, Suzuki Hisanori, Dal Pra Ilaria, Kisselev Lev, Opposite effects of cell differentiation and apoptosis on Ap3A/Ap4A ratio in human cell cultures, FEBS Letters, 415, 2, 1997. Crossref

  5. Grabellus Florian, Sheu Sien-Yi, Schmidt Boris, Flasshove Michael, Kuhnen Cornelius, Ruchholtz Steffen, Taeger Georg, Schmid Kurt Werner, Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation, Virchows Archiv, 448, 1, 2006. Crossref

  6. Huang Sui, Reprogramming cell fates: reconciling rarity with robustness, BioEssays, 31, 5, 2009. Crossref

  7. Abuljadayel Ilham Saleh, Induction of stem cell-like plasticity in mononuclear cells derived from unmobilised adult human peripheral blood, Current Medical Research and Opinion, 19, 5, 2003. Crossref

  8. Mujtaba T., Mayer-Proschel M., Rao M.S., A Common Neural Progenitor for the CNS and PNS, Developmental Biology, 200, 1, 1998. Crossref

  9. Moosavi Mohammad Amin, Rahmati Marveh, Retrodifferentiation: A potential strategy for stem cell therapy of leukemic patients, Medical Hypotheses, 69, 6, 2007. Crossref

  10. Levy Andy, Lightman Stafford, Molecular defects in the pathogenesis of pituitary tumours, Frontiers in Neuroendocrinology, 24, 2, 2003. Crossref

  11. Uwagawa Tadashi, Yanaga Katsuhiko, Effect of NF-κB inhibition on chemoresistance in biliary–pancreatic cancer, Surgery Today, 45, 12, 2015. Crossref

  12. Shen Ruoqian, Dorai Thambi, Szaboles Matthias, Katz Aaron E., Olsson Carl A., Buttyan Ralph, Transdifferentiation of cultured human prostate cancer cells to a neuroendocrine cell phenotype in a hormone-depleted medium, Urologic Oncology: Seminars and Original Investigations, 3, 2, 1997. Crossref

  13. Meinhardt Gerold, Hass Ralf, Differential expression of c-myc, max and mxi1 in human myeloid leukemia cells during retrodifferentiation and cell death, Leukemia Research, 19, 10, 1995. Crossref

  14. Zhang Z., Yuan X.-M., Li L.-H., Xie F.-P., Transdifferentiation of neoplastic cells, Medical Hypotheses, 57, 5, 2001. Crossref

  15. Schepky Andreas G., Meinhardt Gerold, Austermann Sabine, Adermann Knut, Schulz-Knappe Peter, Forssmann Wolf-Georg, Hass Ralf, Specific determination of tyrosine-phosphorylated proteins and peptides by differential iodination, Journal of Chromatography A, 743, 2, 1996. Crossref

  16. Fang Hai-Lin, L'Ecuyer Thomas J., Identification and cloning of a new protein that binds the 3′ untranslated region of α-striated tropomyosin, Molecular Genetics and Metabolism, 76, 2, 2002. Crossref

  17. Tatton W.G, Olanow C.W, Apoptosis in neurodegenerative diseases: the role of mitochondria, Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1410, 2, 1999. Crossref

  18. Huynh Kim Mai, Kim Gyoungmi, Kim Dong-Joon, Yang Suk-Jin, Park Seong-min, Yeom Young-Il, Fisher Paul B., Kang Dongchul, Gene expression analysis of terminal differentiation of human melanoma cells highlights global reductions in cell cycle-associated genes, Gene, 433, 1-2, 2009. Crossref

  19. COOPER STEPHEN, Revisiting the Relationship of the Mammalian G1 Phase to Cell Differentiation, Journal of Theoretical Biology, 208, 4, 2001. Crossref

  20. Holland Eric C., Progenitor cells and glioma formation, Current Opinion in Neurology, 14, 6, 2001. Crossref

  21. Werness Bruce A, Dicioccio Richard A, Piver M.Steven, Identical, unique p53 mutations in a primary ovarian mucinous adenocarcinoma and a synchronous contralateral ovarian mucinous tumor of low malignant potential suggest a common clonal origin, Human Pathology, 28, 5, 1997. Crossref

  22. Meinhardt G, Roth J, Hass R, Activation of protein kinase C relays distinct signaling pathways in the same cell type: differentiation and caspase-mediated apoptosis, Cell Death & Differentiation, 7, 9, 2000. Crossref

  23. Nakai Junko, Kawada Kentaro, Nagata Seigo, Kuramochi Kouji, Uchiro Hiromi, Kobayashi Susumu, Ikekita Masahiko, A novel lipid compound, epolactaene, induces apoptosis: its action is modulated by its side chain structure, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1581, 1-2, 2002. Crossref

  24. Melzer Catharina, von der Ohe Juliane, Hass Ralf, Ungefroren Hendrik, TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b, International Journal of Molecular Sciences, 18, 7, 2017. Crossref

  25. Holland Eric C., Gliomagenesis: genetic alterations and mouse models, Nature Reviews Genetics, 2, 2, 2001. Crossref

  26. Gmyr Valéry, Kerr-Conte Julie, Vandewalle Brigitte, Proye Charles, Lefebvre Jean, Pattou Francçois, Human Pancreatic Ductal Cells: Large-Scale Isolation and Expansion, Cell Transplantation, 10, 1, 2001. Crossref

  27. Bertram Catharina, Hass Ralf, Cellular responses to reactive oxygen species-induced DNA damage and aging, bchm, 389, 3, 2008. Crossref

  28. Muñoz Diana Marcela, Guha Abhijit, Mouse Models to Interrogate the Implications of the Differentiation Status in the Ontogeny of Gliomas, Oncotarget, 2, 8, 2011. Crossref

  29. Melzer Catharina, Ohe Juliane von der, Hass Ralf, Anti-Tumor Effects of Exosomes Derived from Drug-Incubated Permanently Growing Human MSC, International Journal of Molecular Sciences, 21, 19, 2020. Crossref

  30. Hass Ralf, von der Ohe Juliane, Ungefroren Hendrik, The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes, Cancers, 12, 12, 2020. Crossref

  31. Hass Ralf, von der Ohe Juliane, Ungefroren Hendrik, Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness, Cancers, 12, 12, 2020. Crossref

  32. Prudovsky Igor, Popov Konstantin, Akimov Sergey, Serov Sergey, Zelenin Alexander, Meinhardt Gerold, Baier Peter, Sohn Christoph, Hass Ralf, Antisense CD11b integrin inhibits the development of a differentiated monocyte/macrophage phenotype in human leukemia cells, European Journal of Cell Biology, 81, 1, 2002. Crossref

  33. Hass Ralf, Role of MSC in the Tumor Microenvironment, Cancers, 12, 8, 2020. Crossref

  34. Melzer Catharina, Ohe Juliane von der, Hass Ralf, Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC, International Journal of Molecular Sciences, 21, 21, 2020. Crossref

  35. Melzer Catharina, von der Ohe Juliane, Luo Tianjiao, Hass Ralf, Spontaneous Fusion of MSC with Breast Cancer Cells Can Generate Tumor Dormancy, International Journal of Molecular Sciences, 22, 11, 2021. Crossref

  36. Kumar Sanjay, Tomar Munendra Singh, Acharya Arbind, HSF1-mediated regulation of tumor cell apoptosis: a novel target for cancer therapeutics, Future Oncology, 9, 10, 2013. Crossref

  37. Hass Ralf, von der Ohe Juliane, Dittmar Thomas, Cancer Cell Fusion and Post-Hybrid Selection Process (PHSP), Cancers, 13, 18, 2021. Crossref

  38. Meinhardt Gerold, Roth Jeannette, Totok Gabriela, Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways, European Journal of Cell Biology, 79, 11, 2000. Crossref

  39. Zhang Min, Huang Bing, The multi-differentiation potential of peripheral blood mononuclear cells, Stem Cell Research & Therapy, 3, 6, 2012. Crossref

  40. McCullough Karen D., Coleman William B., Ricketts Sharon L., Wilson Julie W., Smith Gary J., Grisham Joe W., Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors , Proceedings of the National Academy of Sciences, 95, 26, 1998. Crossref

  41. Bertram Catharina, Hass Ralf, Matrix Metalloproteinase-7 and the 20 S Proteasome Contribute to Cellular SenescenceA presentation from the 11th Joint Meeting of the Signal Transduction Society (STS), Signal Transduction: Receptors, Mediators and Genes, Weimar, Germany, 1 to 3 November 2007. , Science Signaling, 1, 12, 2008. Crossref

  42. Fernández Carlos, Ramos Adrián M., Sancho Patricia, Amrán Donna, de Blas Elena, Aller Patricio, 12-O-Tetradecanoylphorbol-13-acetate May Both Potentiate and Decrease the Generation of Apoptosis by the Antileukemic Agent Arsenic Trioxide in Human Promonocytic Cells, Journal of Biological Chemistry, 279, 5, 2004. Crossref

  43. Messam Conrad A., Pittman Randall N., Asynchrony and Commitment to Die during Apoptosis, Experimental Cell Research, 238, 2, 1998. Crossref

  44. Paratore Sabrina, Parenti Rosalba, Torrisi Antonietta, Copani Agata, Cicirata Federico, Cavallaro Sebastiano, Genomic profiling of cortical neurons following exposure to β-amyloid, Genomics, 88, 4, 2006. Crossref

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