Therapeutic Strategies for Human IgM Antibodies Directed at Tumor-Associated Ganglioside Antigens: Discoveries Made During the Morton Era and Future Directions

Peter C.  Jones; Reiko F.  Irie

doi:10.1615/CritRevOncog.2016016881

Critical Reviews™ in Oncogenesis

Editor en Jefe: Benjamin Bonavida (open in a new tab)

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

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Therapeutic Strategies for Human IgM Antibodies Directed at Tumor-Associated Ganglioside Antigens: Discoveries Made During the Morton Era and Future Directions

Volumen 21, Edición 1-2, 2016, pp. 75-81

DOI: 10.1615/CritRevOncog.2016016881

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Peter C. Jones
John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California

Reiko F. Irie
John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California

SINOPSIS

Tumor-associated gangliosides have been investigated for their potential as antigenic targets for more than 35 years, culminating in the recent Food and Drug Administration approval of dinutuximab (Unituxin), an IgG antibody targeted against GD2, for the treatment of neuroblastoma in children. This review is focused on discoveries and development of therapeutic approaches involving human IgM antibodies directed against gangliosides, which occurred over the past 40 years at University of California−Los Angeles and the John Wayne Cancer Institute, where Dr. Donald Morton led the surgical oncology department until his death.

PALABRAS CLAVE: IgM, ganglioside, antibody, tumor

CITADO POR

Fazekas-Singer Judit, Singer Josef, Jensen-Jarolim Erika, Precision medicine in clinical oncology: the journey from IgG antibody to IgE, Current Opinion in Allergy & Clinical Immunology, 20, 3, 2020. Crossref
Walker Kenneth W., Foltz Ian N., Wang Tina, Salimi-Moosavi Hossein, Bailis Julie M., Lee Fei, An Phillip, Smith Stephen, Bruno Richele, Wang Zhulun, The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering, Journal of Biological Chemistry, 295, 30, 2020. Crossref
Kim Cheorl-Ho, Gangliosides and Tumor-Associated Ganglioside (TAG) Modulate Receptor-Tyrosine Kinases (RTKs), in Ganglioside Biochemistry, 2020. Crossref

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