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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Genetic and Epigenetic Discoveries in Human Retinoblastoma

Volumen 20, Edición 3-4, 2015, pp. 217-225
DOI: 10.1615/CritRevOncog.2015013711
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SINOPSIS

Retinoblastoma is a rare pediatric cancer of the retina. Nearly all retinoblastomas are initiated through the biallelic inactivation of the retinoblastoma tumor susceptibility gene (RB1). Whole-genome sequencing has made it possible to identify secondary genetic lesions following RB1 inactivation. One of the major discoveries from retinoblastoma sequencing studies is that some retinoblastoma tumors have stable genomes. Subsequent epigenetic studies showed that changes in the epigenome contribute to the rapid progression of retinoblastoma following RB1 gene inactivation. In addition, gene amplification and elevated expression of p53 antagonists, MDM2 and MDM4, may also play an important role in retinoblastoma tumorigenesis. The knowledge gained from these recent molecular, cellular, genomic, and epigenomic analyses are now being integrated to identify new therapeutic approaches that can help save lives and vision in children with retinoblastoma, with fewer long-term side effects.

CITADO POR
  1. Stenfelt Sonya, Blixt Maria K. E., All‐Ericsson Charlotta, Hallböök Finn, Boije Henrik, Heterogeneity in retinoblastoma: a tale of molecules and models, Clinical and Translational Medicine, 6, 1, 2017. Crossref

  2. Fries Peter D., Pediatric Conjunctival and Intraocular Malignancies, in Pediatric Oculoplastic Surgery, 2018. Crossref

  3. Wu Qizheng, Sun Xiao, Zheng Guangying, VEGF overexpression is associated with optic nerve involvement and differentiation of retinoblastoma, Medicine, 97, 51, 2018. Crossref

  4. Chueh Hee Won, Current Assessment and Management of Retinoblastoma, Clinical Pediatric Hematology-Oncology, 26, 1, 2019. Crossref

  5. Dandu Kamakshi, Kallamadi Prathap R., Thakur Suman S., Rao Ch. Mohan, Drug Repurposing for Retinoblastoma: Recent Advances, Current Topics in Medicinal Chemistry, 19, 17, 2019. Crossref

  6. Wu Aimin, Zhou Xuewei, Mi Linglong, Shen Jiang, LINC00202 promotes retinoblastoma progression by regulating cell proliferation, apoptosis, and aerobic glycolysis through miR-204-5p/HMGCR axis, Open Life Sciences, 15, 1, 2020. Crossref

  7. Zeng Zhou, Gao Zhao‑Lin, Zhang Zhi‑Pei, Jiang Hai‑Bo, Yang Chang‑Quan, Yang Jie, Xia Xiao‑Bo, Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway, International Journal of Molecular Medicine, 2019. Crossref

  8. Zhao Xin-mei, Li Yuan-Bin, Sun Peng, Pu Ya-di, shan Meng-jie, Zhang Yuan-meng, Bioinformatics analysis of key biomarkers for retinoblastoma, Journal of International Medical Research, 49, 6, 2021. Crossref

  9. Alekseeva Ekaterina A., Babenko Olga V., Kozlova Valentina M., Ushakova Tatiana L., Kazubskaya Tatiana P., Nemtsova Marina V., Chesnokova Galina G., Mikhaylenko Dmitry S., Bure Irina V., Kalinkin Alexey I., Kuznetsova Ekaterina B., Tanas Alexander S., Kutsev Sergey I., Zaletaev Dmitry V., Strelnikov Vladimir V., Parental Origin of the RB1 Gene Mutations in Families with Low Penetrance Hereditary Retinoblastoma, Cancers, 13, 20, 2021. Crossref

  10. Bao Xian-Yi, Sun Ming, Peng Ting-Ting, Han Dong-Mei, TRIB3 promotes proliferation, migration, and invasion of retinoblastoma cells by activating the AKT/mTOR signaling pathway, Cancer Biomarkers, 31, 4, 2021. Crossref

  11. Slack Jonathan C., Church Alanna J., Molecular Alterations in Pediatric Solid Tumors, Surgical Pathology Clinics, 14, 3, 2021. Crossref

  12. Aschero Rosario, Francis Jasmine H., Ganiewich Daiana, Gomez-Gonzalez Soledad, Sampor Claudia, Zugbi Santiago, Ottaviani Daniela, Lemelle Lauriane, Mena Marcela, Winter Ursula, Correa Llano Genoveva, Lamas Gabriela, Lubieniecki Fabiana, Szijan Irene, Mora Jaume, Podhajcer Osvaldo, Doz François, Radvanyi François, Abramson David H., Llera Andrea S., Schaiquevich Paula S., Lavarino Cinzia, Chantada Guillermo L., Recurrent Somatic Chromosomal Abnormalities in Relapsed Extraocular Retinoblastoma, Cancers, 13, 4, 2021. Crossref

  13. Yao Xiaolei, Shen Hui, Peng Qinghua, Yu Jingsheng, TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma, Cell Cycle, 20, 5-6, 2021. Crossref

  14. González Iván A., Stewart Douglas R., Schultz Kris Ann P., Field Amanda P., Hill D. Ashley, Dehner Louis P., DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma, Modern Pathology, 35, 1, 2022. Crossref

  15. Zhang Li-Juan, Wang Fang, Qi Pei-Yan, Zhou Wei-Yan, Wang Bing, miR-513b-5p inhibits the proliferation and promotes apoptosis of retinoblastoma cells by targeting TRIB1, Open Medicine, 16, 1, 2021. Crossref

  16. Meng Xiangbo, Zhang Yixia, Hu Yongping, Zhong Jianguang, Jiang Chunming, Zhang Hongxu, LncRNA CCAT1 sponges miR-218-5p to promote EMT, cellular migration and invasion of retinoblastoma by targeting MTF2, Cellular Signalling, 86, 2021. Crossref

  17. Liang Ting, Fan Ming, Meng Zhaojun, Sun Bo, Mi Shuyong, Gao Xiangchun, Circ_0000527 Drives Retinoblastoma Progression by Regulating miR-1236-3p/SMAD2 Pathway, Current Eye Research, 47, 4, 2022. Crossref

  18. Babu Vishnu Suresh, Mallipatna Ashwin, SA Deepak, Dudeja Gagan, Kannan Ramaraj, Shetty Rohit, Nair Archana Padmanabhan, Gundimeda Seetharamanjaneyulu, Chaurasia Shyam S., Verma Navin Kumar, Lakshminarayanan Rajamani, Heymans Stephane, Barathi Veluchamy A., Guha Nilanjan, Ghosh Arkasubhra, Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors, Cells, 11, 10, 2022. Crossref

  19. Chai Peiwei, Jia Ruobing, Li Yongyun, Zhou Chuandi, Gu Xiang, Yang Ludi, Shi Hanhan, Tian Hao, Lin Huimin, Yu Jie, Zhuang Ai, Ge Shengfang, Jia Renbing, Fan Xianqun, Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma, Progress in Retinal and Eye Research, 89, 2022. Crossref

  20. Shahraki Moghadam Shadan, Faranoush Mohammad, Johari Moghadam Mohammad Mahdi, Sedaghat Ahad, Ayatollahi Mohammad Jafar, The Concordance of Paternal and Maternal Retinoblastoma-1 Gene Mutation Pattern with Clinical Manifestation and Disease Staging in Patients Suffering from Retinoblastoma, Zahedan Journal of Research in Medical Sciences, 24, 4, 2022. Crossref

  21. Romani Arianna, Zauli Enrico, Zauli Giorgio, AlMesfer Saleh, Al-Swailem Samar, Voltan Rebecca, MDM2 inhibitors-mediated disruption of mitochondrial metabolism: A novel therapeutic strategy for retinoblastoma, Frontiers in Oncology, 12, 2022. Crossref

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