Publicado 4 números por año
ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448
Indexed in
Therapeutic YY1 Inhibitors in Cancer: ALL in ONE
SINOPSIS
Various targeted therapies for cancer have resulted in a significant prolongation of survival and a better quality of life. However, unfortunately, a small subset of cancer patients responds to such therapies initially and then develops resistance after the initial therapies. Based on resistant mechanisms, it should be possible to develop new and specific targeted therapies effective against unresponsive patients. Our investigations and those of others have identified a gene product, Yin Yang 1 (YY1), a transcription factor that is overexpressed in many cancers and that was shown to be involved in the regulation of cell survival, cell proliferation, cell invasion, metastasis, and resistance. Several studies showed that the inhibition of YY1 resulted in significant inhibition of the tumor phenotype and reversal of resistance. Examples of such YY1 inhibitors include siRNA YY1, nitric oxide donors, proteasome inhibitors, and inhibitors of activated survival pathways such as inhibitors of nuclear factor-kappa beta. However, there is still a need to develop specific and targeted inhibitors of YY1. In this review, a general discussion is provided on the role of YY1 overexpression in cancer and the application of various inhibitors of YY1 activities and their potential as therapeutics.
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Wang Yuhao, Bonavida Benjamin, The role of YY1 in the pathogenesis of rheumatoid arthritis: A tale of cytokines, ncRNAs, and aberrant fibroblast-like synoviocytes (FLSs), in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref
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Touboul Roni, Bonavida Benjamin, YY1 expression and PD-1 regulation in CD8 T lymphocytes, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref
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Wang Qian, Zheng Dahai, Li Yuhan, Zhang Ye, Sui Rui, Chen Yi, Liang Haiyang, Shi Ji, Pan Renlong, Xu Xiaobing, Sun Deyu, Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression, The Journal of Gene Medicine, 23, 10, 2021. Crossref
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Zhang Shuya, Kim Ji Young, Xu Suowen, Liu Huan, Yin Meimei, Koroleva Marina, Guo Jia, Pei Xiuying, Jin Zheng Gen, Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ, Proceedings of the National Academy of Sciences, 117, 9, 2020. Crossref
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