Suscripción a Biblioteca: Guest
Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Therapeutic YY1 Inhibitors in Cancer: ALL in ONE

Volumen 22, Edición 1-2, 2017, pp. 37-47
DOI: 10.1615/CritRevOncog.2017020472
Get accessGet access

SINOPSIS

Various targeted therapies for cancer have resulted in a significant prolongation of survival and a better quality of life. However, unfortunately, a small subset of cancer patients responds to such therapies initially and then develops resistance after the initial therapies. Based on resistant mechanisms, it should be possible to develop new and specific targeted therapies effective against unresponsive patients. Our investigations and those of others have identified a gene product, Yin Yang 1 (YY1), a transcription factor that is overexpressed in many cancers and that was shown to be involved in the regulation of cell survival, cell proliferation, cell invasion, metastasis, and resistance. Several studies showed that the inhibition of YY1 resulted in significant inhibition of the tumor phenotype and reversal of resistance. Examples of such YY1 inhibitors include siRNA YY1, nitric oxide donors, proteasome inhibitors, and inhibitors of activated survival pathways such as inhibitors of nuclear factor-kappa beta. However, there is still a need to develop specific and targeted inhibitors of YY1. In this review, a general discussion is provided on the role of YY1 overexpression in cancer and the application of various inhibitors of YY1 activities and their potential as therapeutics.

CITADO POR
  1. Jia Bo, Liu Wei, Gu Jintao, Wang Jiancai, Lv Weifeng, Zhang Wangqian, Hao Qiang, Pang Zhijun, Mu Nan, Zhang Wei, Guo Qingdong, MiR-7-5p suppresses stemness and enhances temozolomide sensitivity of drug-resistant glioblastoma cells by targeting Yin Yang 1, Experimental Cell Research, 375, 1, 2019. Crossref

  2. Bonavida Benjamin, Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1, in Cancer Stem Cell Resistance to Targeted Therapy, 19, 2019. Crossref

  3. Özenver Nadire, Efferth Thomas, Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  4. Bhaskar Rao Divya, Panneerpandian Ponmathi, Balakrishnan Karthik, Ganesan Kumaresan, YY1 regulated transcription‐based stratification of gastric tumors and identification of potential therapeutic candidates, Journal of Cell Communication and Signaling, 15, 2, 2021. Crossref

  5. Panneerpandian Ponmathi, Ganesan Kumaresan, Development of a cell-based pathway modulator screening system to screen the targeted cancer therapeutic candidates, Human Cell, 34, 2, 2021. Crossref

  6. Meliala Ian Timothy Sembiring, Hosea Rendy, Kasim Vivi, Wu Shourong, Yin and Yang of YY1 regulation on tumor metabolic reprogramming, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  7. Wang Yuhao, Bonavida Benjamin, The role of YY1 in the pathogenesis of rheumatoid arthritis: A tale of cytokines, ncRNAs, and aberrant fibroblast-like synoviocytes (FLSs), in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  8. Touboul Roni, Bonavida Benjamin, YY1 expression and PD-1 regulation in CD8 T lymphocytes, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  9. Wang Qian, Zheng Dahai, Li Yuhan, Zhang Ye, Sui Rui, Chen Yi, Liang Haiyang, Shi Ji, Pan Renlong, Xu Xiaobing, Sun Deyu, Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression, The Journal of Gene Medicine, 23, 10, 2021. Crossref

  10. Zhang Shuya, Kim Ji Young, Xu Suowen, Liu Huan, Yin Meimei, Koroleva Marina, Guo Jia, Pei Xiuying, Jin Zheng Gen, Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ, Proceedings of the National Academy of Sciences, 117, 9, 2020. Crossref

  11. Antonio-Andres Gabriela, Martinez-Ruiz Gustavo U., Morales-Martinez Mario, Jiménez-Hernandez Elva, Martinez-Torres Estefany, Lopez-Perez Tania V., Estrada-Abreo Laura A., Patino-Lopez Genaro, Juarez-Mendez Sergio, Davila-Borja Víctor M., Huerta-Yepez Sara, Transcriptional Regulation of Yin-Yang 1 Expression through the Hypoxia Inducible Factor-1 in Pediatric Acute Lymphoblastic Leukemia, International Journal of Molecular Sciences, 23, 3, 2022. Crossref

  12. Tang Seng Chuan, Vijayakumar Udhaya, Zhang Ying, Fullwood Melissa Jane, Super-Enhancers, Phase-Separated Condensates, and 3D Genome Organization in Cancer, Cancers, 14, 12, 2022. Crossref

  13. Dominkuš Pia Pužar, Mesic Aner, Hudler Petra, PLK2 Single Nucleotide Variant in Gastric Cancer Patients Affects miR-23b-5p Binding, Journal of Gastric Cancer, 22, 2022. Crossref

  14. Bonavida Benjamin, Crosstalks between Yin-Yang 1 (YY1) and autophagy in cancer, in Autophagy in Immune Response: Impact on Cancer Immunotherapy, 2020. Crossref

Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain